SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wno'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		3 / 3 TRP A1053
VAL A1070
TRP A1071
 None
 1.09A 1gmkC-5wnoA:
undetectable
1gmkD-5wnoA:
undetectable		 1gmkC-5wnoA:
undetectable
1gmkD-5wnoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 LEU A 891
VAL A 899
ALA A 917
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.46A 1iepA-5wnoA:
27.9		 1iepA-5wnoA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
THR A1027
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.90A 1m17A-5wnoA:
30.5		 1m17A-5wnoA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 9 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LEU A 947
TYR A 965
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
 0.74A 1muoA-5wnoA:
9.3		 1muoA-5wnoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 9 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LEU A1017
TYR A 965
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-4.4A)
 0.94A 1muoA-5wnoA:
9.3		 1muoA-5wnoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 12 ALA A 917
LEU A 947
THR A 963
LEU A1001
HIS A1008
 ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
None
 0.68A 1uwhA-5wnoA:
25.1		 1uwhA-5wnoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 ALA A 917
LYS A 919
LEU A 947
THR A 963
LEU A1001
HIS A1008
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
None
 0.78A 1uwhB-5wnoA:
25.0		 1uwhB-5wnoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 VAL A 899
ALA A 917
LEU A 947
THR A 963
LEU A1001
HIS A1008
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
None
 0.70A 1uwjA-5wnoA:
8.5		 1uwjA-5wnoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 VAL A 899
ALA A 917
LEU A 947
THR A 963
LEU A1001
HIS A1008
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
None
 0.70A 1uwjB-5wnoA:
8.4		 1uwjB-5wnoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 9 LEU A 891
VAL A 899
ALA A 917
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.48A 1xbbA-5wnoA:
29.2		 1xbbA-5wnoA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 ALA A 917
THR A 963
GLY A 969
LEU A1017
THR A1027
ASP A1028
PHE A1029
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
None
 0.61A 1xkkA-5wnoA:
35.6		 1xkkA-5wnoA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 11 GLY A 892
VAL A 899
ALA A 917
TYR A 965
LEU A1017
ASP A1028
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
MG  A1202 ( 3.0A)
 0.62A 2evaA-5wnoA:
26.0		 2evaA-5wnoA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 LEU A 891
GLY A 892
VAL A 899
ALA A 917
TYR A 965
ASN A1015
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
MG  A1202 ( 2.9A)
 0.69A 2fumC-5wnoA:
22.1		 2fumC-5wnoA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 LEU A 891
VAL A 899
ALA A 917
TYR A 965
ASN A1015
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
MG  A1202 ( 2.9A)
MG  A1202 ( 3.0A)
 0.45A 2fumC-5wnoA:
22.1		 2fumC-5wnoA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
ALA A 917
LYS A 919
ILE A 961
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.74A 2gqgA-5wnoA:
28.2		 2gqgA-5wnoA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
VAL A 899
ALA A 917
ILE A 961
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.59A 2gqgB-5wnoA:
28.3		 2gqgB-5wnoA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.65A 2gqgB-5wnoA:
28.3		 2gqgB-5wnoA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
THR A1027
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
 0.77A 2itoA-5wnoA:
31.4		 2itoA-5wnoA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.81A 2ityA-5wnoA:
31.4		 2ityA-5wnoA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
VAL A 899
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
THR A1027
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
 0.76A 2itzA-5wnoA:
31.4		 2itzA-5wnoA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.80A 2oiqA-5wnoA:
28.0		 2oiqA-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
LEU A1017
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
 0.73A 2pl0A-5wnoA:
26.5		 2pl0A-5wnoA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 GLY A 892
VAL A 899
ALA A 917
LEU A 947
TYR A 965
GLY A 969
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
 0.57A 2wgjA-5wnoA:
28.9		 2wgjA-5wnoA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.56A 2y6oA-5wnoA:
28.5		 2y6oA-5wnoA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		9 / 12 VAL A 899
ALA A 917
MET A 938
THR A 963
GLY A 969
LEU A1017
THR A1027
ASP A1028
PHE A1029
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
None
 0.56A 3bbtB-5wnoA:
35.4		 3bbtB-5wnoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		9 / 12 VAL A 899
ALA A 917
THR A 963
GLY A 969
LEU A1017
THR A1027
ASP A1028
PHE A1029
LEU A1031
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
None
None
 0.73A 3bbtB-5wnoA:
35.4		 3bbtB-5wnoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		10 / 12 VAL A 899
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
THR A1027
ASP A1028
PHE A1029
LEU A1031
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
None
None
 0.70A 3bbtD-5wnoA:
35.1		 3bbtD-5wnoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 ALA A 917
LEU A 946
THR A 963
GLY A 969
HIS A1008
LEU A1017
 ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
None
ANP  A1201 (-4.7A)
 0.53A 3cs9A-5wnoA:
28.1		 3cs9A-5wnoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 9 LEU A 891
VAL A 899
LYS A 919
ILE A 961
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-4.7A)
 0.67A 3cs9B-5wnoA:
28.6		 3cs9B-5wnoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 12 ALA A 917
LEU A 946
THR A 963
GLY A 969
HIS A1008
 ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
None
 0.56A 3cs9D-5wnoA:
27.2		 3cs9D-5wnoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		4 / 6 LEU A 891
VAL A 899
LYS A 919
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.7A)
 0.72A 3cs9D-5wnoA:
27.2		 3cs9D-5wnoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		9 / 12 LEU A 891
GLY A 892
GLY A 894
GLY A 897
VAL A 899
ALA A 917
LYS A 919
ASN A1015
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-2.8A)
None
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
MG  A1202 ( 2.9A)
ANP  A1201 (-4.7A)
 0.76A 3eygA-5wnoA:
27.1		 3eygA-5wnoA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		9 / 12 LEU A 891
GLY A 894
GLY A 897
VAL A 899
ALA A 917
LYS A 919
ASN A1015
LEU A1017
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 (-2.8A)
None
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
MG  A1202 ( 2.9A)
ANP  A1201 (-4.7A)
MG  A1202 ( 3.0A)
 0.86A 3eygA-5wnoA:
27.1		 3eygA-5wnoA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 12 GLN A1114
LEU A1120
GLN A 987
TYR A1117
LEU A1116
 None
 1.19A 3fsuA-5wnoA:
undetectable		 3fsuA-5wnoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		9 / 12 LEU A 891
GLY A 892
GLY A 894
GLY A 897
VAL A 899
ALA A 917
LYS A 919
TYR A 965
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-2.8A)
None
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
 0.71A 3fupA-5wnoA:
27.7		 3fupA-5wnoA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 11 LEU A 891
VAL A 899
ALA A 917
THR A 963
TYR A 965
GLY A 969
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
 0.54A 3g0eA-5wnoA:
25.5		 3g0eA-5wnoA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 11 LEU A 891
VAL A 899
ALA A 917
THR A 963
TYR A 965
GLY A 969
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
 0.57A 3g0fA-5wnoA:
25.6		 3g0fA-5wnoA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 11 LEU A 891
VAL A 899
ALA A 917
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.60A 3g0fA-5wnoA:
25.6		 3g0fA-5wnoA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 10 LEU A 891
VAL A 899
ALA A 917
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.71A 3g0fB-5wnoA:
26.0		 3g0fB-5wnoA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
VAL A 899
ALA A 917
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.63A 3g5dA-5wnoA:
28.3		 3g5dA-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
VAL A 899
ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.80A 3g5dB-5wnoA:
28.3		 3g5dB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 10 GLU A1079
VAL A1075
ILE A1096
LEU A1100
THR A1013
 None
 1.09A 3jw5B-5wnoA:
undetectable		 3jw5B-5wnoA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.80A 3k54A-5wnoA:
27.9		 3k54A-5wnoA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LYS A 919
TYR A 965
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
 0.72A 3lxkA-5wnoA:
27.9		 3lxkA-5wnoA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
GLY A 892
GLY A 894
VAL A 899
ALA A 917
LYS A 919
TYR A 965
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-2.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
 0.61A 3lxnA-5wnoA:
27.8		 3lxnA-5wnoA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 LEU A 891
VAL A 899
ALA A 917
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.47A 3mssB-5wnoA:
27.9		 3mssB-5wnoA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
VAL A 899
ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.67A 3octA-5wnoA:
27.9		 3octA-5wnoA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 VAL A 899
ALA A 917
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.59A 3oezA-5wnoA:
27.9		 3oezA-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
LEU A1017
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
 0.59A 3oezB-5wnoA:
28.4		 3oezB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 12 VAL A 899
ALA A 917
LEU A 947
THR A 963
PHE A1029
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
 0.54A 3og7A-5wnoA:
27.3		 3og7A-5wnoA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 GLY A 892
VAL A 899
ALA A 917
LYS A 919
THR A 963
LEU A1017
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.7A)
 0.98A 3ohtA-5wnoA:
3.9		 3ohtA-5wnoA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 GLY A 892
VAL A 899
ALA A 917
LYS A 919
THR A 963
GLY A 969
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
 0.83A 3ohtB-5wnoA:
4.7		 3ohtB-5wnoA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 GLY A 892
VAL A 899
ALA A 917
LYS A 919
THR A 963
LEU A1017
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.7A)
 0.99A 3ohtB-5wnoA:
4.7		 3ohtB-5wnoA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 LEU A 891
VAL A 899
ALA A 917
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.69A 3pyyA-5wnoA:
28.1		 3pyyA-5wnoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
VAL A 899
ALA A 917
THR A 963
TYR A 965
GLY A 969
LEU A1017
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
MG  A1202 ( 3.0A)
 0.81A 3qlgB-5wnoA:
28.5		 3qlgB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
VAL A 899
ALA A 917
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.49A 3sxrA-5wnoA:
27.9		 3sxrA-5wnoA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
VAL A 899
ALA A 917
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.44A 3sxrB-5wnoA:
27.5		 3sxrB-5wnoA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 9 LEU A 975
ILE A1158
GLN A 987
GLU A 986
GLU A1166
 None
 1.19A 3tmzA-5wnoA:
undetectable		 3tmzA-5wnoA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
ALA A 917
LYS A 919
ILE A 961
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.50A 3ue4A-5wnoA:
28.7		 3ue4A-5wnoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
VAL A 899
ALA A 917
ILE A 961
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.56A 3ue4B-5wnoA:
28.6		 3ue4B-5wnoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 LEU A 891
GLY A 892
VAL A 899
ALA A 917
PHE A1029
LEU A1031
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
None
 0.83A 3wzdA-5wnoA:
27.8		 3wzdA-5wnoA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 12 LEU A 891
VAL A 899
ALA A 917
GLY A 969
PHE A1029
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 ( 4.6A)
None
 0.46A 3wzdA-5wnoA:
27.8		 3wzdA-5wnoA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 12 LEU A 891
ALA A 917
LEU A 947
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.57A 3zbfA-5wnoA:
28.2		 3zbfA-5wnoA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 LYS A 919
ILE A 961
ASP A1010
ASN A1015
ASP A1028
GLY A1030
 ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.7A)
MG  A1202 ( 2.9A)
MG  A1202 ( 3.0A)
None
 0.79A 4an2A-5wnoA:
25.4		 4an2A-5wnoA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 10 LEU A 891
GLY A 892
VAL A 899
ALA A 917
TYR A 965
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
 0.58A 4ckjA-5wnoA:
27.7		 4ckjA-5wnoA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		9 / 12 LEU A 891
VAL A 899
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
THR A1027
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.61A 4hjoA-5wnoA:
34.4		 4hjoA-5wnoA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		9 / 12 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LYS A 919
GLY A 969
LEU A1017
THR A1027
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.65A 4i22A-5wnoA:
34.6		 4i22A-5wnoA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		4 / 7 ILE A 949
LEU A1031
GLY A1030
PHE A1029
 None
 0.70A 4iqqB-5wnoA:
undetectable		 4iqqB-5wnoA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		4 / 7 ILE A 949
LEU A1031
GLY A1030
PHE A1029
 None
 0.76A 4iqqC-5wnoA:
undetectable		 4iqqC-5wnoA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 LYS A 919
ILE A 961
ASN A1015
ASP A1028
PHE A1029
GLY A1030
 ANP  A1201 (-3.8A)
None
MG  A1202 ( 2.9A)
MG  A1202 ( 3.0A)
None
None
 0.67A 4lmnA-5wnoA:
24.4		 4lmnA-5wnoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
 0.64A 4mxoA-5wnoA:
27.9		 4mxoA-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		9 / 12 LEU A 891
VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.68A 4mxoB-5wnoA:
27.6		 4mxoB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.74A 4mxxA-5wnoA:
27.9		 4mxxA-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
THR A1027
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
 0.80A 4mxxA-5wnoA:
27.9		 4mxxA-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
VAL A 899
ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.74A 4mxxB-5wnoA:
27.9		 4mxxB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
VAL A 899
ALA A 917
LYS A 919
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.66A 4mxyB-5wnoA:
28.0		 4mxyB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
VAL A 899
ALA A 917
LYS A 919
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.66A 4mxzB-5wnoA:
28.0		 4mxzB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 11 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LEU A 947
ASN A1015
LEU A1017
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
MG  A1202 ( 2.9A)
ANP  A1201 (-4.7A)
MG  A1202 ( 3.0A)
 0.95A 4o0sA-5wnoA:
22.7		 4o0sA-5wnoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
VAL A 899
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.54A 4otwA-5wnoA:
34.6		 4otwA-5wnoA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 VAL A 899
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
ASP A1028
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
MG  A1202 ( 3.0A)
 0.73A 4otwA-5wnoA:
34.6		 4otwA-5wnoA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA703_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		4 / 4 LEU A 968
PHE A 974
LEU A1163
GLU A1166
 None
 1.20A 4p7nA-5wnoA:
undetectable		 4p7nA-5wnoA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 12 ALA A 917
LEU A 947
ILE A 961
THR A 963
PHE A1029
 ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
None
ANP  A1201 (-3.9A)
None
 0.57A 4rzvA-5wnoA:
27.9		 4rzvA-5wnoA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 12 VAL A 899
ALA A 917
LEU A 947
THR A 963
PHE A1029
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
 0.58A 4rzvB-5wnoA:
27.6		 4rzvB-5wnoA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		4 / 6 LEU A 891
VAL A 899
LYS A 919
ILE A1026
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
None
 0.70A 4tyjA-5wnoA:
28.0		 4tyjA-5wnoA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		4 / 6 LEU A 891
VAL A 899
LYS A 919
ILE A1026
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
None
 0.71A 4tyjA-5wnoA:
28.0		 4tyjA-5wnoA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 9 LEU A 891
VAL A 899
ALA A 917
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.58A 4u5jB-5wnoA:
28.8		 4u5jB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 9 LEU A 891
VAL A 899
LYS A 919
TYR A 965
LEU A1017
ILE A1026
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
None
 0.82A 4v01A-5wnoA:
27.9		 4v01A-5wnoA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 9 LEU A 891
VAL A 899
LYS A 919
TYR A 965
LEU A1017
ILE A1026
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
None
 0.70A 4v01B-5wnoA:
28.2		 4v01B-5wnoA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 10 LEU A 891
VAL A 899
LYS A 919
TYR A 965
LEU A1017
ILE A1026
LEU A1031
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
None
None
 1.38A 4v04B-5wnoA:
27.9		 4v04B-5wnoA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 11 LEU A 891
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.81A 4wa9A-5wnoA:
26.8		 4wa9A-5wnoA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
THR A1027
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
 0.70A 4wkqA-5wnoA:
31.1		 4wkqA-5wnoA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 9 LEU A1137
GLY A1133
ILE A 994
LEU A1011
VAL A1070
 None
 1.14A 4x3mB-5wnoA:
undetectable		 4x3mB-5wnoA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.55A 4xliA-5wnoA:
28.5		 4xliA-5wnoA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.69A 4xliB-5wnoA:
28.4		 4xliB-5wnoA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 10 LEU A 891
VAL A 899
ALA A 917
LYS A 919
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.50A 5aacA-5wnoA:
27.5		 5aacA-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 LEU A 891
VAL A 899
ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.46A 5bvwA-5wnoA:
26.3		 5bvwA-5wnoA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 9 ILE A1158
GLY A 983
LEU A 982
ASN A1022
LEU A 989
 None
 1.34A 5fhzB-5wnoA:
undetectable		 5fhzB-5wnoA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
ALA A 917
LEU A 947
ILE A 961
GLY A 969
LEU A1017
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
None
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
MG  A1202 ( 3.0A)
 0.73A 5h2uC-5wnoA:
31.6		 5h2uC-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
ALA A 917
LEU A 947
THR A 963
GLY A 969
LEU A1017
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
MG  A1202 ( 3.0A)
 0.64A 5h2uC-5wnoA:
31.6		 5h2uC-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 LEU A 891
VAL A 899
ALA A 917
ILE A 961
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.60A 5h2uD-5wnoA:
31.7		 5h2uD-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 LEU A 891
VAL A 899
ALA A 917
LEU A 947
ILE A 961
GLY A 969
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
None
ANP  A1201 ( 4.6A)
 0.62A 5h2uD-5wnoA:
31.7		 5h2uD-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 LEU A 891
VAL A 899
ALA A 917
LEU A 947
THR A 963
GLY A 969
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
 0.55A 5h2uD-5wnoA:
31.7		 5h2uD-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 LEU A 891
VAL A 899
ALA A 917
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.63A 5h2uD-5wnoA:
31.7		 5h2uD-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 VAL A 899
ALA A 917
LEU A 947
THR A 963
GLY A 969
ASP A1028
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
MG  A1202 ( 3.0A)
 0.64A 5h2uD-5wnoA:
31.7		 5h2uD-5wnoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 VAL A 899
ALA A 917
ILE A 961
THR A 963
TYR A 965
PHE A1029
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
None
 0.65A 5hesB-5wnoA:
25.9		 5hesB-5wnoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
 0.60A 5hesB-5wnoA:
25.9		 5hesB-5wnoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 ALA A 917
LYS A 919
LEU A 947
THR A 963
LEU A1001
HIS A1008
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
None
 0.85A 5hi2A-5wnoA:
25.0		 5hi2A-5wnoA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 GLY A 894
VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
 ANP  A1201 (-2.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
 0.67A 5hieA-5wnoA:
25.3		 5hieA-5wnoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 12 VAL A 899
ALA A 917
LEU A 947
ILE A 961
THR A 963
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
None
ANP  A1201 (-3.9A)
 0.55A 5hieA-5wnoA:
25.3		 5hieA-5wnoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 GLY A 894
VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
 ANP  A1201 (-2.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
 0.65A 5hieB-5wnoA:
25.3		 5hieB-5wnoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 12 VAL A 899
ALA A 917
LEU A 947
ILE A 961
THR A 963
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
None
ANP  A1201 (-3.9A)
 0.56A 5hieB-5wnoA:
25.3		 5hieB-5wnoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 GLY A 892
GLY A 894
VAL A 899
ALA A 917
LYS A 919
THR A 963
 ANP  A1201 ( 3.8A)
ANP  A1201 (-2.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
 0.87A 5hieC-5wnoA:
25.5		 5hieC-5wnoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 GLY A 892
PHE A 921
VAL A 899
ALA A 917
LEU A 947
THR A 963
 ANP  A1201 ( 3.8A)
None
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
 1.17A 5hieC-5wnoA:
25.5		 5hieC-5wnoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 GLY A 894
VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
 ANP  A1201 (-2.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
 0.66A 5hieD-5wnoA:
25.4		 5hieD-5wnoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 12 VAL A 899
ALA A 917
LEU A 947
ILE A 961
THR A 963
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
None
ANP  A1201 (-3.9A)
 0.56A 5hieD-5wnoA:
25.4		 5hieD-5wnoA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.66A 5i9xA-5wnoA:
27.9		 5i9xA-5wnoA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.67A 5i9yA-5wnoA:
28.0		 5i9yA-5wnoA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		5 / 10 LEU A 891
VAL A 899
LYS A 919
ILE A 961
GLY A 969
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
None
ANP  A1201 ( 4.6A)
 0.63A 5mo4A-5wnoA:
5.4		 5mo4A-5wnoA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 10 LEU A 891
VAL A 899
ALA A 917
TYR A 965
LEU A1017
THR A1027
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
 0.45A 5n3hA-5wnoA:
20.9		 5n3hA-5wnoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		4 / 7 ILE A 949
LEU A1031
GLY A1030
PHE A1029
 None
 0.81A 5nooA-5wnoA:
undetectable		 5nooA-5wnoA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		4 / 7 ILE A 949
LEU A1031
GLY A1030
PHE A1029
 None
 0.74A 5nooB-5wnoA:
undetectable		 5nooB-5wnoA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 ALA A 917
MET A 938
THR A 963
GLY A 969
ASN A 973
LEU A1017
PHE A1029
 ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
None
ANP  A1201 (-4.7A)
None
 0.70A 5p9iA-5wnoA:
29.9		 5p9iA-5wnoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 GLY A 897
VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
PHE A1029
 None
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
None
 1.28A 5p9iA-5wnoA:
29.9		 5p9iA-5wnoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		8 / 12 VAL A 899
ALA A 917
ILE A 961
THR A 963
GLY A 969
ASN A 973
LEU A1017
PHE A1029
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
None
ANP  A1201 (-4.7A)
None
 0.81A 5p9iA-5wnoA:
29.9		 5p9iA-5wnoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
ASN A 973
PHE A1029
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
None
None
 1.04A 5p9iA-5wnoA:
29.9		 5p9iA-5wnoA:
13.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 GLY A 892
VAL A 899
ALA A 917
LYS A 919
MET A 938
THR A1027
ASP A1028
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.91A 5yu9A-5wnoA:
34.5		 5yu9A-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 GLY A 892
VAL A 899
ALA A 917
MET A 938
LEU A1017
THR A1027
ASP A1028
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.77A 5yu9A-5wnoA:
34.5		 5yu9A-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LEU A1017
THR A1027
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.64A 5yu9A-5wnoA:
34.5		 5yu9A-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LYS A 919
THR A1027
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.77A 5yu9A-5wnoA:
34.5		 5yu9A-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 GLY A 892
VAL A 899
ALA A 917
LYS A 919
MET A 938
THR A1027
ASP A1028
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.94A 5yu9B-5wnoA:
34.6		 5yu9B-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 GLY A 892
VAL A 899
ALA A 917
MET A 938
LEU A1017
THR A1027
ASP A1028
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.77A 5yu9B-5wnoA:
34.6		 5yu9B-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 VAL A 899
ALA A 917
LYS A 919
MET A 938
THR A1027
ASP A1028
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.96A 5yu9C-5wnoA:
34.5		 5yu9C-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 VAL A 899
ALA A 917
MET A 938
GLY A 969
THR A1027
ASP A1028
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 ( 4.6A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.81A 5yu9C-5wnoA:
34.5		 5yu9C-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 VAL A 899
ALA A 917
GLY A 969
LEU A1017
THR A1027
ASP A1028
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.64A 5yu9D-5wnoA:
34.6		 5yu9D-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 VAL A 899
ALA A 917
LYS A 919
MET A 938
THR A1027
ASP A1028
LEU A1031
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
None
 1.05A 5yu9D-5wnoA:
34.6		 5yu9D-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 VAL A 899
ALA A 917
MET A 938
LEU A1017
THR A1027
ASP A1028
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.81A 5yu9D-5wnoA:
34.6		 5yu9D-5wnoA:
42.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		7 / 12 VAL A 899
ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.46A 6bsdA-5wnoA:
25.9		 6bsdA-5wnoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23
(Caenorhabditis
elegans) 		6 / 12 VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
LEU A1017
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.7A)
 0.61A 6hd4A-5wnoA:
27.8		 6hd4A-5wnoA:
28.89