SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wo6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 11 LEU A  50
LEU A  51
ALA A  52
LEU A  64
LEU A  98
 LEU  A  50 ( 0.6A)
LEU  A  51 ( 0.6A)
ALA  A  52 ( 0.0A)
LEU  A  64 ( 0.6A)
LEU  A  98 ( 0.6A)
 1.28A 1g50A-5wo6A:
undetectable		 1g50A-5wo6A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 10 LEU A  50
LEU A  51
ALA A  52
LEU A  64
LEU A  98
 LEU  A  50 ( 0.6A)
LEU  A  51 ( 0.6A)
ALA  A  52 ( 0.0A)
LEU  A  64 ( 0.6A)
LEU  A  98 ( 0.6A)
 1.28A 1gwrA-5wo6A:
undetectable		 1gwrA-5wo6A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_A_MTXA1278_1
(PTERIDINE REDUCTASE
2)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 10 TYR A 154
LEU A 205
TYR A 161
LEU A 240
THR A 298
 TYR  A 154 ( 1.3A)
LEU  A 205 ( 0.6A)
TYR  A 161 ( 1.3A)
LEU  A 240 ( 0.6A)
THR  A 298 ( 0.8A)
 1.13A 1mxfA-5wo6A:
undetectable		 1mxfA-5wo6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_B_MTXB2278_1
(PTERIDINE REDUCTASE
2)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 11 TYR A 154
LEU A 205
TYR A 161
LEU A 240
THR A 298
 TYR  A 154 ( 1.3A)
LEU  A 205 ( 0.6A)
TYR  A 161 ( 1.3A)
LEU  A 240 ( 0.6A)
THR  A 298 ( 0.8A)
 1.13A 1mxfB-5wo6A:
undetectable		 1mxfB-5wo6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 11 TYR A 154
LEU A 205
TYR A 161
LEU A 240
THR A 298
 TYR  A 154 ( 1.3A)
LEU  A 205 ( 0.6A)
TYR  A 161 ( 1.3A)
LEU  A 240 ( 0.6A)
THR  A 298 ( 0.8A)
 1.17A 1mxfC-5wo6A:
undetectable		 1mxfC-5wo6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 11 TYR A 154
LEU A 205
TYR A 161
LEU A 240
THR A 298
 TYR  A 154 ( 1.3A)
LEU  A 205 ( 0.6A)
TYR  A 161 ( 1.3A)
LEU  A 240 ( 0.6A)
THR  A 298 ( 0.8A)
 1.18A 1mxfD-5wo6A:
undetectable		 1mxfD-5wo6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		3 / 3 GLU A 249
GLN A 305
ARG A 304
 GLU  A 249 ( 0.6A)
GLN  A 305 ( 0.6A)
ARG  A 304 ( 0.6A)
 0.79A 2w3bB-5wo6A:
undetectable		 2w3bB-5wo6A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 12 LEU A  50
ALA A  52
LEU A  65
LEU A  64
LEU A  98
 LEU  A  50 ( 0.6A)
ALA  A  52 ( 0.0A)
LEU  A  65 ( 0.5A)
LEU  A  64 ( 0.6A)
LEU  A  98 ( 0.6A)
 1.10A 3erdA-5wo6A:
2.1		 3erdA-5wo6A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 12 LEU A  50
ALA A  52
LEU A  65
LEU A  64
LEU A  98
 LEU  A  50 ( 0.6A)
ALA  A  52 ( 0.0A)
LEU  A  65 ( 0.5A)
LEU  A  64 ( 0.6A)
LEU  A  98 ( 0.6A)
 1.10A 3hm1A-5wo6A:
undetectable		 3hm1A-5wo6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		4 / 4 ILE A 295
ARG A 262
ILE A 306
THR A 297
 ILE  A 295 ( 0.7A)
ARG  A 262 ( 0.6A)
ILE  A 306 ( 0.7A)
THR  A 297 ( 0.8A)
 1.16A 3ia4C-5wo6A:
undetectable		 3ia4C-5wo6A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		3 / 3 ASN A  57
ASN A  91
GLU A  93
 ASN  A  57 ( 0.6A)
ASN  A  91 ( 0.6A)
GLU  A  93 ( 0.6A)
 0.88A 3kpdC-5wo6A:
undetectable		 3kpdC-5wo6A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 12 GLY A 448
VAL A 437
MET A 434
ILE A 556
PHE A 552
 GLY  A 448 ( 0.0A)
VAL  A 437 ( 0.6A)
MET  A 434 ( 0.0A)
ILE  A 556 ( 0.7A)
PHE  A 552 ( 1.3A)
 1.41A 3mnoA-5wo6A:
undetectable		 3mnoA-5wo6A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		4 / 4 LEU A 167
PRO A 166
LEU A 182
ILE A 183
 LEU  A 167 ( 0.6A)
PRO  A 166 ( 1.1A)
LEU  A 182 ( 0.6A)
ILE  A 183 ( 0.7A)
 0.98A 4f4dB-5wo6A:
undetectable		 4f4dB-5wo6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 12 LEU A 136
ALA A 135
ASN A  92
ALA A  86
ALA A 120
 LEU  A 136 ( 0.6A)
ALA  A 135 ( 0.0A)
ASN  A  92 ( 0.6A)
ALA  A  86 ( 0.0A)
ALA  A 120 ( 0.0A)
 1.00A 4x20B-5wo6A:
undetectable		 4x20B-5wo6A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 12 LEU A 137
LEU A 132
ALA A 120
VAL A 106
ALA A 141
 LEU  A 137 ( 0.6A)
LEU  A 132 ( 0.6A)
ALA  A 120 ( 0.0A)
VAL  A 106 ( 0.6A)
ALA  A 141 ( 0.0A)
 0.99A 4x20B-5wo6A:
undetectable		 4x20B-5wo6A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		5 / 11 LEU A  50
ALA A  52
LEU A  65
LEU A  64
LEU A  98
 LEU  A  50 ( 0.6A)
ALA  A  52 ( 0.0A)
LEU  A  65 ( 0.5A)
LEU  A  64 ( 0.6A)
LEU  A  98 ( 0.6A)
 1.14A 4zn7B-5wo6A:
undetectable		 4zn7B-5wo6A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		4 / 8 ILE A 189
LEU A 219
MET A 215
LEU A 218
 ILE  A 189 ( 0.7A)
LEU  A 219 ( 0.6A)
MET  A 215 ( 0.0A)
LEU  A 218 ( 0.6A)
 1.02A 5u4sB-5wo6A:
undetectable		 5u4sB-5wo6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Rattus
norvegicus) 		3 / 3 ARG A 588
ARG A 491
ARG A 593
 ARG  A 588 ( 0.6A)
ARG  A 491 ( 0.6A)
ARG  A 593 ( 0.6A)
 0.82A 5vcgA-5wo6A:
undetectable		 5vcgA-5wo6A:
20.94