SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wog'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1IWH_A_PEMA501_1 (HEMOGLOBIN ALPHA CHAIN)	5wog	HEMOGLOBIN SUBUNIT ALPHA (Homo sapiens)	5 / 6	LYS A 60 LYS A 61 ASP A 64 ALA A 65 LEU A 83	None HEM A 201 (-2.5A) None HEM A 201 ( 3.8A) HEM A 201 (-4.3A)	0.56A	1iwhA-5wogA: 26.4	1iwhA-5wogA: 86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LH6_A_NIOA155_1 (LEGHEMOGLOBIN A (NICOTINATE MET))	5wog	HEMOGLOBIN SUBUNIT ALPHA (Homo sapiens)	4 / 7	PHE A 43 PHE A 46 VAL A 62 HIS A 87	HEM A 201 (-3.8A) HEM A 201 ( 4.9A) HEM A 201 ( 3.9A) HEM A 201 (-3.3A)	0.93A	1lh6A-5wogA: 13.8	1lh6A-5wogA: 23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XCT_X_CPFX1020_1 (DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A)	5wog	HEMOGLOBIN SUBUNIT ALPHA (Homo sapiens)	4 / 4	ARG A 31 GLY A 25 GLU A 27 SER A 133	None	1.16A	2xctS-5wogA: undetectable 2xctU-5wogA: undetectable	2xctS-5wogA: 9.02 2xctU-5wogA: 9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SMT_A_ACTA500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD3)	5wog	HEMOGLOBIN SUBUNIT ALPHA (Homo sapiens)	3 / 3	PHE A 46 SER A 52 GLN A 54	HEM A 201 ( 4.9A) None None	0.83A	3smtA-5wogA: undetectable	3smtA-5wogA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IWH_A_PEMA501_1","HEMOGLOBIN ALPHA CHAIN","5wog","HEMOGLOBIN SUBUNIT ALPHA","Homo sapiens",5,"LYS A  60;LYS A  61;ASP A  64;ALA A  65;LEU A  83","None;HEM A 201 (-2.5A);None;HEM A 201 ( 3.8A);HEM A 201 (-4.3A)","0.56A","1iwhA-5wogA:26.4","1iwhA-5wogA:86.25"],["1LH6_A_NIOA155_1","LEGHEMOGLOBIN A (NICOTINATE MET)","5wog","HEMOGLOBIN SUBUNIT ALPHA","Homo sapiens",4,"PHE A  43;PHE A  46;VAL A  62;HIS A  87","HEM A 201 (-3.8A);HEM A 201 ( 4.9A);HEM A 201 ( 3.9A);HEM A 201 (-3.3A)","0.93A","1lh6A-5wogA:13.8","1lh6A-5wogA:23.20"],["2XCT_X_CPFX1020_1","DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A","5wog","HEMOGLOBIN SUBUNIT ALPHA","Homo sapiens",4,"ARG A  31;GLY A  25;GLU A  27;SER A 133","None","1.16A","2xctS-5wogA:undetectable;2xctU-5wogA:undetectable","2xctS-5wogA:9.02;2xctU-5wogA:9.02"],["3SMT_A_ACTA500_0","HISTONE-LYSINE N-METHYLTRANSFERASE SETD3","5wog","HEMOGLOBIN SUBUNIT ALPHA","Homo sapiens",3,"PHE A  46;SER A  52;GLN A  54","HEM A 201 ( 4.9A);None;None","0.83A","3smtA-5wogA:undetectable","3smtA-5wogA:undetectable"]]