SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wol'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 5wol 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Coxiella
burnetii) 		4 / 6 ILE A 130
LYS A 119
ALA A 122
MET A 156
 None
 1.20A 1hk2A-5wolA:
undetectable		 1hk2A-5wolA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 5wol 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Coxiella
burnetii) 		5 / 11 GLY A 234
ALA A 104
VAL A  76
GLY A 217
ILE A 102
 None
 0.93A 1n49B-5wolA:
undetectable		 1n49B-5wolA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 5wol 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Coxiella
burnetii) 		5 / 11 GLY A 234
ALA A 104
VAL A  76
GLY A 217
ILE A 102
 None
 0.92A 1n49C-5wolA:
undetectable		 1n49C-5wolA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5wol 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Coxiella
burnetii) 		3 / 3 ASP A  91
LEU A 228
LEU A 231
 None
 0.78A 1np1B-5wolA:
undetectable		 1np1B-5wolA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 5wol 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Coxiella
burnetii) 		5 / 11 LEU A  28
GLY A 100
ILE A 102
VAL A   5
ILE A   3
 None
 1.02A 1sduA-5wolA:
undetectable		 1sduA-5wolA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 5wol 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Coxiella
burnetii) 		6 / 10 GLY A 234
ALA A 104
VAL A  76
ILE A 218
GLY A 217
ILE A 102
 None
 1.29A 3ekpD-5wolA:
undetectable		 3ekpD-5wolA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 5wol 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Coxiella
burnetii) 		4 / 5 ALA A  73
ALA A  49
ILE A  44
LEU A  40
 None
 0.70A 5jncD-5wolA:
undetectable		 5jncD-5wolA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5wol 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Coxiella
burnetii) 		3 / 3 VAL A 193
ALA A 118
GLN A 191
 None
 0.69A 6gb9A-5wolA:
undetectable		 6gb9A-5wolA:
21.18