SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wp4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 TYR A 246
GLY A 292
SER A 314
MET A 317
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-4.0A)
 0.90A 1kiaA-5wp4A:
16.4		 1kiaA-5wp4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 TYR A 246
GLY A 292
SER A 314
MET A 317
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-4.0A)
 0.91A 1kiaD-5wp4A:
15.9		 1kiaD-5wp4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 TYR A 246
GLY A 292
SER A 314
MET A 317
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-4.0A)
 0.82A 1nbhA-5wp4A:
15.6		 1nbhA-5wp4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 TYR A 246
GLY A 292
SER A 314
MET A 317
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-4.0A)
 0.82A 1nbhB-5wp4A:
17.3		 1nbhB-5wp4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 TYR A 246
GLY A 292
SER A 314
MET A 317
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-4.0A)
 0.81A 1nbhC-5wp4A:
17.4		 1nbhC-5wp4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 TYR A 246
GLY A 292
SER A 314
MET A 317
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-4.0A)
 0.82A 1nbhD-5wp4A:
17.2		 1nbhD-5wp4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 TYR A 246
GLY A 292
SER A 314
MET A 317
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-4.0A)
 1.07A 1nbiC-5wp4A:
15.5		 1nbiC-5wp4A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 TYR A 246
GLY A 292
SER A 314
MET A 317
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-4.0A)
 1.05A 1nbiD-5wp4A:
15.5		 1nbiD-5wp4A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		3 / 3 TRP A 374
LEU A 375
LYS A 490
 None
 1.39A 1yajK-5wp4A:
undetectable		 1yajK-5wp4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
ASP A 107
VAL A 108
LEU A 128
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.2A)
SAH  A 701 (-3.6A)
None
 0.93A 1zq9B-5wp4A:
12.8		 1zq9B-5wp4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 292
LEU A 313
ASP A 338
ILE A 361
 SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.1A)
SAH  A 703 (-3.3A)
None
 0.83A 1zq9B-5wp4A:
12.8		 1zq9B-5wp4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 9 LEU A  60
LEU A  81
ILE A  79
LEU A 120
ILE A 123
 None
 1.21A 2f78A-5wp4A:
undetectable		 2f78A-5wp4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 9 LEU A  60
LEU A  81
ILE A  79
LEU A 120
ILE A 123
 None
 1.24A 2f78B-5wp4A:
undetectable		 2f78B-5wp4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 9 LEU A  60
LEU A  81
ILE A  79
LEU A 120
ILE A 123
 None
 1.15A 2f7aB-5wp4A:
undetectable		 2f7aB-5wp4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
ASP A 107
VAL A 108
TYR A 131
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.2A)
SAH  A 701 (-3.6A)
None
 0.58A 2qe6B-5wp4A:
13.9		 2qe6B-5wp4A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 6 PHE A 372
PHE A 423
GLY A 378
GLY A 379
 None
 1.01A 2qr2A-5wp4A:
undetectable
2qr2B-5wp4A:
undetectable		 2qr2A-5wp4A:
20.14
2qr2B-5wp4A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 ILE A 311
LEU A 241
THR A 357
ILE A 361
LEU A 367
 None
SAH  A 703 (-4.0A)
SAH  A 703 (-3.2A)
None
None
 1.09A 2w3bA-5wp4A:
undetectable		 2w3bA-5wp4A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLU A 335
TYR A 344
TRP A 374
PHE A 371
GLY A 310
 None
 1.24A 2xffA-5wp4A:
undetectable		 2xffA-5wp4A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 5 ALA A 413
GLY A 484
CYH A 387
LYS A 482
 None
 0.81A 2yldA-5wp4A:
undetectable		 2yldA-5wp4A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 5 ALA A 413
GLY A 484
CYH A 387
LYS A 482
 None
 1.20A 2ylgA-5wp4A:
undetectable		 2ylgA-5wp4A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 5 GLU A  59
ARG A  66
ASP A  82
ASP A 107
 None
SAH  A 701 (-3.9A)
SAH  A 701 (-2.9A)
SAH  A 701 (-3.2A)
 0.70A 2yqzA-5wp4A:
16.5		 2yqzA-5wp4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 5 GLU A  59
ARG A  66
ASP A  82
ASP A 107
 None
SAH  A 701 (-3.9A)
SAH  A 701 (-2.9A)
SAH  A 701 (-3.2A)
 0.68A 2yqzB-5wp4A:
16.5		 2yqzB-5wp4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 8 LEU A 128
ALA A 141
LEU A 140
MET A 144
 None
 0.74A 3cldB-5wp4A:
undetectable		 3cldB-5wp4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 VAL A 289
GLY A 290
GLY A 292
PHE A 262
THR A 357
 None
SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
None
SAH  A 703 (-3.2A)
 0.90A 3dh0A-5wp4A:
18.5		 3dh0A-5wp4A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 8 ARG A 192
GLN A 238
GLU A 335
GLU A 200
 None
 1.35A 3dh0A-5wp4A:
18.5		 3dh0A-5wp4A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
PHE A  83
ASP A 107
VAL A 108
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.2A)
SAH  A 701 (-3.6A)
 0.51A 3dlcA-5wp4A:
16.9		 3dlcA-5wp4A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 292
SER A 314
ASP A 338
ARG A 355
 SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
None
 0.98A 3dlcA-5wp4A:
16.9		 3dlcA-5wp4A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
ASP A 107
VAL A 108
ASN A 126
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.2A)
SAH  A 701 (-3.6A)
SAH  A 701 (-4.0A)
 0.73A 3dmfA-5wp4A:
12.5		 3dmfA-5wp4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 VAL A 289
GLY A 290
GLY A 292
ASP A 338
ILE A 361
 None
SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-3.3A)
None
 0.69A 3fuuA-5wp4A:
10.4		 3fuuA-5wp4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
GLY A  65
ASP A 107
LEU A 128
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
None
SAH  A 701 (-3.2A)
None
 0.72A 3ihtA-5wp4A:
10.3		 3ihtA-5wp4A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 TRP A  16
GLY A  61
PHE A  83
ASP A 107
THR A 109
LEU A 128
 SAH  A 701 (-3.8A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.2A)
SAH  A 701 ( 4.6A)
None
 0.78A 3iv6A-5wp4A:
17.8		 3iv6A-5wp4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 TRP A  16
GLY A  61
ASP A  82
PHE A  83
ASP A 107
LEU A 128
 SAH  A 701 (-3.8A)
SAH  A 701 (-3.4A)
SAH  A 701 (-2.9A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.2A)
None
 0.70A 3iv6B-5wp4A:
18.3		 3iv6B-5wp4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 TRP A  16
GLY A  61
PHE A  83
ASP A 107
ARG A 157
LEU A 128
 SAH  A 701 (-3.8A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.2A)
None
None
 0.85A 3iv6C-5wp4A:
17.7		 3iv6C-5wp4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 TRP A  16
GLY A  61
PHE A  83
ASP A 107
ARG A 157
LEU A 128
 SAH  A 701 (-3.8A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.2A)
None
None
 0.79A 3iv6D-5wp4A:
18.5		 3iv6D-5wp4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 GLY A  61
GLY A  63
PHE A  83
ASP A 107
ARG A   9
TYR A 131
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.2A)
SAH  A 701 (-3.9A)
None
 1.24A 3o7wA-5wp4A:
12.4		 3o7wA-5wp4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		3 / 3 TYR A 246
ASP A 312
ASP A 338
 SAH  A 703 ( 4.0A)
SAH  A 703 (-2.6A)
SAH  A 703 (-3.3A)
 0.78A 3ou7B-5wp4A:
19.7		 3ou7B-5wp4A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		3 / 3 GLY A  63
ASP A  82
ASP A 107
 SAH  A 701 (-3.5A)
SAH  A 701 (-2.9A)
SAH  A 701 (-3.2A)
 0.35A 3ou7C-5wp4A:
19.3		 3ou7C-5wp4A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		3 / 3 GLY A 292
ASP A 312
ASP A 338
 SAH  A 703 ( 3.7A)
SAH  A 703 (-2.6A)
SAH  A 703 (-3.3A)
 0.39A 3ou7C-5wp4A:
19.3		 3ou7C-5wp4A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		7 / 12 TYR A 246
GLY A 292
LEU A 313
SER A 314
MET A 317
ASP A 338
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-3.3A)
SAH  A 703 (-4.0A)
 0.57A 3pfgA-5wp4A:
16.1		 3pfgA-5wp4A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 TYR A 246
GLY A 292
SER A 314
MET A 317
PHE A 258
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
None
 1.33A 3pfgA-5wp4A:
16.1		 3pfgA-5wp4A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 296
LEU A 313
ASP A 338
CYH A 339
 SAH  A 703 (-4.0A)
None
SAH  A 703 (-4.1A)
SAH  A 703 (-3.3A)
SAH  A 703 (-3.5A)
 0.80A 3r24A-5wp4A:
8.9		 3r24A-5wp4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLU A  59
GLY A  61
GLY A  63
ASP A 107
VAL A 108
 None
SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.2A)
SAH  A 701 (-3.6A)
 0.75A 3sglA-5wp4A:
6.5		 3sglA-5wp4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 LEU A 241
TYR A 246
GLY A 290
ARG A 355
ASP A 356
HIS A 360
 SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
None
PC  A 702 ( 4.6A)
SAH  A 703 (-4.0A)
 0.43A 3uj6A-5wp4A:
40.4		 3uj6A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 LEU A 241
TYR A 246
GLY A 290
ILE A 311
ARG A 355
ASP A 356
 SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
None
None
PC  A 702 ( 4.6A)
 1.08A 3uj6A-5wp4A:
40.4		 3uj6A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 LEU A 241
TYR A 246
GLY A 292
ILE A 251
ARG A 355
ASP A 356
 SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
None
None
PC  A 702 ( 4.6A)
 1.28A 3uj6A-5wp4A:
40.4		 3uj6A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 LEU A 241
TYR A 246
ILE A 251
ARG A 355
ASP A 356
HIS A 360
 SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
None
None
PC  A 702 ( 4.6A)
SAH  A 703 (-4.0A)
 1.24A 3uj6A-5wp4A:
40.4		 3uj6A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 LEU A 241
TYR A 246
GLY A 290
ARG A 355
ASP A 356
HIS A 360
 SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
None
PC  A 702 ( 4.6A)
SAH  A 703 (-4.0A)
 0.43A 3uj7A-5wp4A:
40.0		 3uj7A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 LEU A 241
TYR A 246
GLY A 290
ILE A 311
ARG A 355
 SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
None
None
 1.08A 3uj7A-5wp4A:
40.0		 3uj7A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 LEU A 241
TYR A 246
ILE A 251
ARG A 355
ASP A 356
 SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
None
None
PC  A 702 ( 4.6A)
 1.15A 3uj7A-5wp4A:
40.0		 3uj7A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 LEU A 375
ILE A 352
ILE A 383
ASP A 425
ALA A 488
 None
 1.29A 3uj7A-5wp4A:
40.0		 3uj7A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 LEU A 241
GLY A 290
GLY A 292
ARG A 355
ASP A 356
HIS A 360
 SAH  A 703 (-4.0A)
SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
None
PC  A 702 ( 4.6A)
SAH  A 703 (-4.0A)
 0.36A 3uj7B-5wp4A:
40.5		 3uj7B-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 5 TYR A 246
SER A 264
ASP A 312
ASP A 338
 SAH  A 703 ( 4.0A)
SAH  A 703 (-2.6A)
SAH  A 703 (-2.6A)
SAH  A 703 (-3.3A)
 0.20A 3uj7B-5wp4A:
40.5		 3uj7B-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 11 GLY A  63
ASP A  82
ASP A 107
VAL A 108
LEU A 132
 SAH  A 701 (-3.5A)
SAH  A 701 (-2.9A)
SAH  A 701 (-3.2A)
SAH  A 701 (-3.6A)
None
 0.88A 3v8vB-5wp4A:
13.3		 3v8vB-5wp4A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 6 GLU A  70
GLY A  69
LEU A  46
GLU A  59
 None
 0.80A 3w9tB-5wp4A:
undetectable		 3w9tB-5wp4A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 6 GLU A  70
GLY A  69
LEU A  46
GLU A  59
 None
 0.79A 3w9tE-5wp4A:
undetectable		 3w9tE-5wp4A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 6 GLU A  70
GLY A  69
LEU A  46
GLU A  59
 None
 0.82A 3w9tF-5wp4A:
undetectable		 3w9tF-5wp4A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 5 ALA A 413
GLY A 484
CYH A 387
LYS A 482
 None
 0.77A 3zwiA-5wp4A:
undetectable		 3zwiA-5wp4A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 LEU A 241
ASP A 288
GLY A 292
GLY A 295
LEU A 313
 SAH  A 703 (-4.0A)
SAH  A 703 ( 4.6A)
SAH  A 703 ( 3.7A)
None
SAH  A 703 (-4.1A)
 0.79A 4blvA-5wp4A:
10.1		 4blvA-5wp4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 6 LEU A  81
ALA A  62
LEU A  60
SER A 125
 None
 1.26A 4d7bB-5wp4A:
undetectable		 4d7bB-5wp4A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 7 GLU A 399
TYR A 400
ARG A 404
GLY A 468
LYS A 472
 None
PC  A 702 (-4.5A)
PC  A 702 (-3.9A)
None
PC  A 702 (-2.7A)
 0.49A 4fgzA-5wp4A:
40.1		 4fgzA-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 8 GLU A 399
TYR A 400
ARG A 404
GLY A 468
LYS A 472
 None
PC  A 702 (-4.5A)
PC  A 702 (-3.9A)
None
PC  A 702 (-2.7A)
 0.57A 4fgzA-5wp4A:
40.1
4fgzB-5wp4A:
40.1		 4fgzA-5wp4A:
23.28
4fgzB-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 294
GLY A 295
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
 0.53A 4fp9D-5wp4A:
10.5		 4fp9D-5wp4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 294
GLY A 296
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
 0.90A 4fp9D-5wp4A:
10.5		 4fp9D-5wp4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 294
GLY A 295
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
 0.45A 4fzvA-5wp4A:
10.4		 4fzvA-5wp4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 294
GLY A 296
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
 0.84A 4fzvA-5wp4A:
10.4		 4fzvA-5wp4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 ALA A 325
ILE A 251
ASP A 288
GLY A 292
GLY A 290
 None
None
SAH  A 703 ( 4.6A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.0A)
 1.20A 4hfpB-5wp4A:
undetectable		 4hfpB-5wp4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 TYR A 246
GLY A 290
GLY A 292
ARG A 355
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
None
SAH  A 703 (-4.0A)
 0.18A 4iv0A-5wp4A:
39.4		 4iv0A-5wp4A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 4 SER A 264
ASP A 312
MET A 317
ASP A 338
 SAH  A 703 (-2.6A)
SAH  A 703 (-2.6A)
SAH  A 703 (-3.8A)
SAH  A 703 (-3.3A)
 0.63A 4iv0A-5wp4A:
39.4		 4iv0A-5wp4A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		7 / 12 TYR A 246
GLY A 290
GLY A 292
MET A 317
ASP A 338
ARG A 355
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-3.8A)
SAH  A 703 (-3.3A)
None
SAH  A 703 (-4.0A)
 0.55A 4iv0B-5wp4A:
38.1		 4iv0B-5wp4A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
ASP A  82
ASP A 107
LEU A 132
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-2.9A)
SAH  A 701 (-3.2A)
None
 0.35A 4iv8A-5wp4A:
33.7		 4iv8A-5wp4A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		7 / 12 GLY A 290
GLY A 292
ASP A 312
MET A 317
ASP A 338
ARG A 355
HIS A 360
 SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-2.6A)
SAH  A 703 (-3.8A)
SAH  A 703 (-3.3A)
None
SAH  A 703 (-4.0A)
 0.50A 4iv8A-5wp4A:
33.7		 4iv8A-5wp4A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
ASP A  82
ASP A 107
LEU A 132
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-2.9A)
SAH  A 701 (-3.2A)
None
 0.35A 4iv8B-5wp4A:
33.5		 4iv8B-5wp4A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 GLY A 290
GLY A 292
ASP A 312
ASP A 338
ARG A 355
LEU A 367
 SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-2.6A)
SAH  A 703 (-3.3A)
None
None
 1.14A 4iv8B-5wp4A:
33.5		 4iv8B-5wp4A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		7 / 12 GLY A 290
GLY A 292
ASP A 312
MET A 317
ASP A 338
ARG A 355
HIS A 360
 SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-2.6A)
SAH  A 703 (-3.8A)
SAH  A 703 (-3.3A)
None
SAH  A 703 (-4.0A)
 0.54A 4iv8B-5wp4A:
33.5		 4iv8B-5wp4A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 ILE A 311
LEU A 241
ILE A 361
LEU A 367
VAL A 289
 None
SAH  A 703 (-4.0A)
None
None
None
 1.07A 4kfjB-5wp4A:
undetectable		 4kfjB-5wp4A:
16.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		10 / 12 PHE A 237
TYR A 246
GLY A 290
GLY A 292
LEU A 313
SER A 314
ASP A 338
ARG A 355
HIS A 360
ILE A 361
 None
SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
None
SAH  A 703 (-4.0A)
None
 0.61A 4krhA-5wp4A:
39.2		 4krhA-5wp4A:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		10 / 12 PHE A 237
TYR A 246
PHE A 262
GLY A 290
GLY A 292
LEU A 313
SER A 314
ARG A 355
HIS A 360
ILE A 361
 None
SAH  A 703 ( 4.0A)
None
SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
None
SAH  A 703 (-4.0A)
None
 0.71A 4krhB-5wp4A:
39.4		 4krhB-5wp4A:
33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 5 TYR A 400
THR A 271
THR A 432
MET A 436
 PC  A 702 (-4.5A)
None
None
None
 1.46A 4mbsB-5wp4A:
undetectable		 4mbsB-5wp4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 TYR A 246
GLY A 290
GLY A 292
MET A 317
ARG A 355
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-3.8A)
None
SAH  A 703 (-4.0A)
 0.57A 4mwzA-5wp4A:
37.8		 4mwzA-5wp4A:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		3 / 3 SER A 264
ASP A 312
ASP A 338
 SAH  A 703 (-2.6A)
SAH  A 703 (-2.6A)
SAH  A 703 (-3.3A)
 0.20A 4mwzA-5wp4A:
37.8		 4mwzA-5wp4A:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 TYR A 246
GLY A 290
GLY A 292
ARG A 355
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
None
SAH  A 703 (-4.0A)
 0.19A 4mwzB-5wp4A:
39.4		 4mwzB-5wp4A:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 4 SER A 264
ASP A 312
MET A 317
ASP A 338
 SAH  A 703 (-2.6A)
SAH  A 703 (-2.6A)
SAH  A 703 (-3.8A)
SAH  A 703 (-3.3A)
 0.63A 4mwzB-5wp4A:
39.4		 4mwzB-5wp4A:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 292
SER A 314
MET A 317
HIS A 360
 SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-4.0A)
 0.83A 4qdjA-5wp4A:
18.9		 4qdjA-5wp4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 292
GLY A 294
LEU A 313
THR A 340
 SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
None
SAH  A 703 (-4.1A)
SAH  A 703 ( 4.3A)
 0.83A 4uckA-5wp4A:
7.1		 4uckA-5wp4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 5 PHE A  67
PHE A 155
PHE A 124
VAL A  45
 SAH  A 701 (-4.6A)
None
None
None
 1.05A 5a1rA-5wp4A:
1.0		 5a1rA-5wp4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 4 ASP A 288
GLY A 292
ASP A 312
ASP A 338
 SAH  A 703 ( 4.6A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-2.6A)
SAH  A 703 (-3.3A)
 0.57A 5e72A-5wp4A:
14.6		 5e72A-5wp4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 5 ALA A 413
GLY A 484
CYH A 387
LYS A 482
 None
 1.07A 5jliA-5wp4A:
undetectable		 5jliA-5wp4A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		3 / 3 TYR A 406
TYR A 254
GLN A 245
 PC  A 702 (-4.7A)
PC  A 702 (-4.0A)
PC  A 702 (-4.1A)
 0.88A 5jsdA-5wp4A:
undetectable
5jsdB-5wp4A:
undetectable		 5jsdA-5wp4A:
19.97
5jsdB-5wp4A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		3 / 3 TYR A 406
TYR A 254
GLN A 245
 PC  A 702 (-4.7A)
PC  A 702 (-4.0A)
PC  A 702 (-4.1A)
 0.88A 5jsdB-5wp4A:
undetectable
5jsdC-5wp4A:
undetectable		 5jsdB-5wp4A:
19.97
5jsdC-5wp4A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 5 ALA A 413
GLY A 484
CYH A 387
LYS A 482
 None
 0.99A 5jt4A-5wp4A:
undetectable		 5jt4A-5wp4A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A  63
ASP A 107
VAL A 108
THR A 109
LEU A 128
 SAH  A 701 (-3.5A)
SAH  A 701 (-3.2A)
SAH  A 701 (-3.6A)
SAH  A 701 ( 4.6A)
None
 0.66A 5kocA-5wp4A:
23.1		 5kocA-5wp4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
ASP A 107
VAL A 108
THR A 109
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.2A)
SAH  A 701 (-3.6A)
SAH  A 701 ( 4.6A)
 0.64A 5kpcB-5wp4A:
22.8		 5kpcB-5wp4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 SER A 264
GLY A 290
GLY A 292
SER A 314
ASP A 338
THR A 340
 SAH  A 703 (-2.6A)
SAH  A 703 (-4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.3A)
SAH  A 703 ( 4.3A)
 0.91A 5kpcB-5wp4A:
22.8		 5kpcB-5wp4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 6 LEU A  81
ALA A  62
LEU A  60
SER A 125
 None
 1.26A 5l4iB-5wp4A:
undetectable		 5l4iB-5wp4A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 8 TYR A 400
ARG A 404
ARG A 475
TRP A 469
 PC  A 702 (-4.5A)
PC  A 702 (-3.9A)
None
None
 1.42A 5l8dA-5wp4A:
undetectable		 5l8dA-5wp4A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 8 TYR A 400
ARG A 404
ARG A 475
TRP A 469
 PC  A 702 (-4.5A)
PC  A 702 (-3.9A)
None
None
 1.42A 5mwuA-5wp4A:
undetectable		 5mwuA-5wp4A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 ASP A  38
GLU A  41
LEU A  78
PHE A 124
ARG A 157
 None
 1.04A 5nd2B-5wp4A:
undetectable		 5nd2B-5wp4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 MET A 130
SER A 125
GLU A  59
VAL A  45
PHE A  67
 PC  A 704 (-4.3A)
None
None
None
SAH  A 701 (-4.6A)
 1.36A 5vlmB-5wp4A:
undetectable		 5vlmB-5wp4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 GLY A  61
GLY A  63
ASP A  82
VAL A 108
LEU A 128
LEU A 132
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-2.9A)
SAH  A 701 (-3.6A)
None
None
 0.53A 5wy0A-5wp4A:
14.3		 5wy0A-5wp4A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 VAL A  45
VAL A  25
MET A  28
LEU A 122
LEU A  49
 None
None
SAH  A 701 ( 3.8A)
None
None
 1.09A 5xxiA-5wp4A:
undetectable		 5xxiA-5wp4A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		3 / 3 SER A 167
HIS A  19
TYR A  15
 None
 1.03A 5y2tA-5wp4A:
undetectable		 5y2tA-5wp4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 296
LEU A 313
ASP A 338
CYH A 339
 SAH  A 703 (-4.0A)
None
SAH  A 703 (-4.1A)
SAH  A 703 (-3.3A)
SAH  A 703 (-3.5A)
 0.73A 5yn6A-5wp4A:
9.3		 5yn6A-5wp4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 GLY A 290
GLY A 296
ASP A 312
LEU A 313
ASP A 338
CYH A 339
 SAH  A 703 (-4.0A)
None
SAH  A 703 (-2.6A)
SAH  A 703 (-4.1A)
SAH  A 703 (-3.3A)
SAH  A 703 (-3.5A)
 0.79A 5yniA-5wp4A:
8.0		 5yniA-5wp4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 295
ASP A 312
LEU A 313
ASP A 338
CYH A 339
 None
SAH  A 703 (-2.6A)
SAH  A 703 (-4.1A)
SAH  A 703 (-3.3A)
SAH  A 703 (-3.5A)
 0.99A 5yniA-5wp4A:
8.0		 5yniA-5wp4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		6 / 12 GLY A 290
GLY A 296
ASP A 312
LEU A 313
ASP A 338
CYH A 339
 SAH  A 703 (-4.0A)
None
SAH  A 703 (-2.6A)
SAH  A 703 (-4.1A)
SAH  A 703 (-3.3A)
SAH  A 703 (-3.5A)
 0.82A 5ynmA-5wp4A:
7.5		 5ynmA-5wp4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 295
ASP A 312
LEU A 313
ASP A 338
CYH A 339
 None
SAH  A 703 (-2.6A)
SAH  A 703 (-4.1A)
SAH  A 703 (-3.3A)
SAH  A 703 (-3.5A)
 1.02A 5ynmA-5wp4A:
7.5		 5ynmA-5wp4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
ASP A  82
VAL A  87
ASP A 107
LEU A 128
 SAH  A 701 (-3.4A)
SAH  A 701 (-2.9A)
None
SAH  A 701 (-3.2A)
None
 1.07A 6bq4B-5wp4A:
11.9		 6bq4B-5wp4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		4 / 5 TYR A 414
GLY A 415
HIS A 409
ASP A 407
 None
 1.23A 6gh9A-5wp4A:
undetectable		 6gh9A-5wp4A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		3 / 3 TRP A 224
ILE A 222
GLU A 178
 None
 0.83A 6hcxA-5wp4A:
undetectable		 6hcxA-5wp4A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 11 GLY A  61
GLY A  63
ASP A  82
VAL A  87
ASP A 107
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-2.9A)
None
SAH  A 701 (-3.2A)
 0.75A 6i5zD-5wp4A:
13.1		 6i5zD-5wp4A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1
(Arabidopsis
thaliana) 		5 / 11 GLY A  61
GLY A  63
ASP A  82
VAL A  87
TRP A 127
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-2.9A)
None
PC  A 704 ( 3.4A)
 0.73A 6i5zD-5wp4A:
13.1		 6i5zD-5wp4A:
23.90