SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wp5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 6 GLY A  63
ASP A  82
TYR A 131
SER A  86
 SAH  A 502 (-3.5A)
SAH  A 502 (-2.9A)
SAH  A 502 ( 4.8A)
None
 0.98A 1eswA-5wp5A:
undetectable		 1eswA-5wp5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
ASP A 107
VAL A 108
LEU A 128
 SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.2A)
SAH  A 502 (-3.6A)
None
 0.98A 1zq9B-5wp5A:
12.6		 1zq9B-5wp5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 292
LEU A 313
ASP A 338
ILE A 361
 SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.9A)
SAH  A 501 (-3.4A)
None
 0.79A 1zq9B-5wp5A:
12.6		 1zq9B-5wp5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 7 ILE A 361
LEU A 367
TYR A 414
THR A 384
 None
 1.02A 2dyrN-5wp5A:
undetectable
2dyrW-5wp5A:
undetectable		 2dyrN-5wp5A:
20.45
2dyrW-5wp5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		6 / 12 GLY A 261
ASP A 288
GLY A 290
GLY A 292
GLY A 294
LEU A 313
 None
SAH  A 501 ( 4.4A)
SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-3.9A)
 1.38A 2oxtD-5wp5A:
8.9		 2oxtD-5wp5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
ASP A 107
VAL A 108
TYR A 131
 SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.2A)
SAH  A 502 (-3.6A)
SAH  A 502 ( 4.8A)
 0.55A 2qe6B-5wp5A:
13.3		 2qe6B-5wp5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLU A 335
TYR A 344
TRP A 374
PHE A 371
GLY A 310
 None
 1.27A 2xffA-5wp5A:
undetectable		 2xffA-5wp5A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 5 ALA A 413
GLY A 484
CYH A 387
LYS A 482
 None
 0.80A 2yldA-5wp5A:
undetectable		 2yldA-5wp5A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 5 ALA A 413
GLY A 484
CYH A 387
LYS A 482
 None
 1.14A 2ylgA-5wp5A:
undetectable		 2ylgA-5wp5A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 5 GLU A  59
ARG A  66
ASP A  82
ASP A 107
 None
SAH  A 502 (-4.0A)
SAH  A 502 (-2.9A)
SAH  A 502 (-3.2A)
 0.55A 2yqzA-5wp5A:
15.7		 2yqzA-5wp5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 5 GLU A  59
ARG A  66
ASP A  82
ASP A 107
 None
SAH  A 502 (-4.0A)
SAH  A 502 (-2.9A)
SAH  A 502 (-3.2A)
 0.54A 2yqzB-5wp5A:
15.8		 2yqzB-5wp5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 7 ILE A 361
LEU A 367
TYR A 414
THR A 384
 None
 1.05A 3ablA-5wp5A:
1.2
3ablJ-5wp5A:
undetectable		 3ablA-5wp5A:
20.45
3ablJ-5wp5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 7 ILE A 361
LEU A 367
TYR A 414
THR A 384
 None
 1.04A 3ag2N-5wp5A:
1.2
3ag2W-5wp5A:
undetectable		 3ag2N-5wp5A:
20.45
3ag2W-5wp5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
PHE A  83
ASP A 107
VAL A 108
 SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.2A)
SAH  A 502 (-3.6A)
 0.55A 3dlcA-5wp5A:
15.3		 3dlcA-5wp5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
ASP A 107
VAL A 108
ASN A 126
 SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.2A)
SAH  A 502 (-3.6A)
SAH  A 502 (-3.9A)
 0.71A 3dmfA-5wp5A:
12.7		 3dmfA-5wp5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 VAL A 289
GLY A 290
GLY A 292
ASP A 338
ILE A 361
 None
SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.4A)
None
 0.74A 3fuuA-5wp5A:
11.3		 3fuuA-5wp5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		3 / 3 ARG A 180
GLU A 188
ASP A 234
 None
 0.84A 3g2oA-5wp5A:
17.0		 3g2oA-5wp5A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
GLY A  65
ASP A 107
LEU A 128
 SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
None
SAH  A 502 (-3.2A)
None
 0.74A 3ihtA-5wp5A:
9.8		 3ihtA-5wp5A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		6 / 12 TRP A  16
GLY A  61
PHE A  83
ASP A 107
THR A 109
LEU A 128
 SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.2A)
SAH  A 502 ( 4.8A)
None
 0.82A 3iv6A-5wp5A:
17.7		 3iv6A-5wp5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		6 / 12 TRP A  16
GLY A  61
ASP A  82
PHE A  83
ASP A 107
LEU A 128
 SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-2.9A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.2A)
None
 0.69A 3iv6B-5wp5A:
18.6		 3iv6B-5wp5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		6 / 12 TRP A  16
GLY A  61
PHE A  83
ASP A 107
ARG A 157
LEU A 128
 SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.2A)
None
None
 0.87A 3iv6C-5wp5A:
17.7		 3iv6C-5wp5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		6 / 12 TRP A  16
GLY A  61
PHE A  83
ASP A 107
ARG A 157
LEU A 128
 SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.2A)
None
None
 0.82A 3iv6D-5wp5A:
18.9		 3iv6D-5wp5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		6 / 12 GLY A  61
GLY A  63
PHE A  83
ASP A 107
ARG A   9
TYR A 131
 SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.2A)
SAH  A 502 (-3.7A)
SAH  A 502 ( 4.8A)
 1.16A 3o7wA-5wp5A:
12.3		 3o7wA-5wp5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		3 / 3 GLY A  63
ASP A  82
ASP A 107
 SAH  A 502 (-3.5A)
SAH  A 502 (-2.9A)
SAH  A 502 (-3.2A)
 0.40A 3ou7C-5wp5A:
18.5		 3ou7C-5wp5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		3 / 3 GLY A 292
ASP A 312
ASP A 338
 SAH  A 501 (-3.6A)
SAH  A 501 (-2.8A)
SAH  A 501 (-3.4A)
 0.39A 3ou7C-5wp5A:
18.5		 3ou7C-5wp5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		6 / 12 GLY A 292
LEU A 313
SER A 314
MET A 317
ASP A 338
HIS A 360
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.9A)
None
SAH  A 501 (-4.0A)
SAH  A 501 (-3.4A)
SAH  A 501 (-4.0A)
 0.43A 3pfgA-5wp5A:
16.4		 3pfgA-5wp5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 296
LEU A 313
ASP A 338
CYH A 339
 SAH  A 501 (-3.8A)
None
SAH  A 501 (-3.9A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.5A)
 0.84A 3r24A-5wp5A:
8.2		 3r24A-5wp5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 9 GLY A 422
ASP A 424
ASP A 425
GLY A 379
ILE A 383
 None
 0.91A 3s53A-5wp5A:
undetectable		 3s53A-5wp5A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLU A  59
GLY A  61
GLY A  63
ASP A 107
VAL A 108
 None
SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.2A)
SAH  A 502 (-3.6A)
 0.69A 3sglA-5wp5A:
6.7		 3sglA-5wp5A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 LEU A 375
ILE A 352
ILE A 383
ASP A 425
ALA A 488
 None
 1.37A 3uj7A-5wp5A:
33.2		 3uj7A-5wp5A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 292
ARG A 355
ASP A 356
HIS A 360
 SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
None
None
SAH  A 501 (-4.0A)
 0.18A 3uj7B-5wp5A:
33.4		 3uj7B-5wp5A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 11 GLY A  63
ASP A  82
ASP A 107
VAL A 108
LEU A 132
 SAH  A 502 (-3.5A)
SAH  A 502 (-2.9A)
SAH  A 502 (-3.2A)
SAH  A 502 (-3.6A)
None
 0.90A 3v8vB-5wp5A:
13.2		 3v8vB-5wp5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 6 GLU A  70
GLY A  69
LEU A  46
GLU A  59
 None
 0.66A 3w9tB-5wp5A:
undetectable		 3w9tB-5wp5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 6 GLU A  70
GLY A  69
LEU A  46
GLU A  59
 None
 0.66A 3w9tE-5wp5A:
undetectable		 3w9tE-5wp5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 6 GLU A  70
GLY A  69
LEU A  46
GLU A  59
 None
 0.69A 3w9tF-5wp5A:
undetectable		 3w9tF-5wp5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 6 ILE A 361
LEU A 367
TYR A 414
THR A 384
 None
 1.00A 3wg7A-5wp5A:
undetectable
3wg7J-5wp5A:
undetectable		 3wg7A-5wp5A:
20.45
3wg7J-5wp5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 5 ALA A 413
GLY A 484
CYH A 387
LYS A 482
 None
 0.76A 3zwiA-5wp5A:
undetectable		 3zwiA-5wp5A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 6 LEU A  81
ALA A  62
LEU A  60
SER A 125
 None
 1.23A 4d7bB-5wp5A:
undetectable		 4d7bB-5wp5A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 7 GLU A 396
GLU A 399
TYR A 400
ARG A 404
LYS A 472
 None
 0.91A 4fgzA-5wp5A:
33.5		 4fgzA-5wp5A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 7 GLU A 396
TYR A 400
ARG A 404
GLY A 468
LYS A 472
 None
 1.27A 4fgzA-5wp5A:
33.5		 4fgzA-5wp5A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A 294
GLY A 295
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 501 (-3.9A)
None
SAH  A 501 (-3.4A)
 0.45A 4fp9D-5wp5A:
10.6		 4fp9D-5wp5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A 294
GLY A 296
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 501 (-3.9A)
None
SAH  A 501 (-3.4A)
 0.87A 4fp9D-5wp5A:
10.6		 4fp9D-5wp5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A 294
GLY A 295
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 501 (-3.9A)
None
SAH  A 501 (-3.4A)
 0.47A 4fzvA-5wp5A:
10.4		 4fzvA-5wp5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A 294
GLY A 296
LEU A 313
SER A 314
ASP A 338
 None
None
SAH  A 501 (-3.9A)
None
SAH  A 501 (-3.4A)
 0.87A 4fzvA-5wp5A:
10.4		 4fzvA-5wp5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 ALA A 325
ILE A 251
ASP A 288
GLY A 292
GLY A 290
 None
None
SAH  A 501 ( 4.4A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.8A)
 1.28A 4hfpB-5wp5A:
undetectable		 4hfpB-5wp5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 4 SER A 264
ASP A 312
MET A 317
ASP A 338
 SAH  A 501 (-2.6A)
SAH  A 501 (-2.8A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.4A)
 0.63A 4iv0A-5wp5A:
32.9		 4iv0A-5wp5A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		6 / 12 GLY A 290
GLY A 292
MET A 317
ASP A 338
ARG A 355
HIS A 360
 SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.4A)
None
SAH  A 501 (-4.0A)
 0.58A 4iv0B-5wp5A:
33.2		 4iv0B-5wp5A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
ASP A  82
ASP A 107
LEU A 132
 SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-2.9A)
SAH  A 502 (-3.2A)
None
 0.34A 4iv8A-5wp5A:
31.0		 4iv8A-5wp5A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		7 / 12 GLY A 290
GLY A 292
ASP A 312
MET A 317
ASP A 338
ARG A 355
HIS A 360
 SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
SAH  A 501 (-2.8A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.4A)
None
SAH  A 501 (-4.0A)
 0.44A 4iv8A-5wp5A:
31.0		 4iv8A-5wp5A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
ASP A  82
ASP A 107
LEU A 132
 SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-2.9A)
SAH  A 502 (-3.2A)
None
 0.35A 4iv8B-5wp5A:
30.9		 4iv8B-5wp5A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		7 / 12 GLY A 290
GLY A 292
ASP A 312
MET A 317
ASP A 338
ARG A 355
HIS A 360
 SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
SAH  A 501 (-2.8A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.4A)
None
SAH  A 501 (-4.0A)
 0.47A 4iv8B-5wp5A:
30.9		 4iv8B-5wp5A:
25.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		8 / 12 GLY A 290
GLY A 292
LEU A 313
SER A 314
ASP A 338
ARG A 355
HIS A 360
ILE A 361
 SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.9A)
None
SAH  A 501 (-3.4A)
None
SAH  A 501 (-4.0A)
None
 0.66A 4krhA-5wp5A:
31.8		 4krhA-5wp5A:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		7 / 12 GLY A 290
GLY A 292
LEU A 313
SER A 314
ARG A 355
HIS A 360
ILE A 361
 SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.9A)
None
None
SAH  A 501 (-4.0A)
None
 0.62A 4krhB-5wp5A:
31.8		 4krhB-5wp5A:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 292
MET A 317
ARG A 355
HIS A 360
 SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.0A)
None
SAH  A 501 (-4.0A)
 0.61A 4mwzA-5wp5A:
33.6		 4mwzA-5wp5A:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		3 / 3 SER A 264
ASP A 312
ASP A 338
 SAH  A 501 (-2.6A)
SAH  A 501 (-2.8A)
SAH  A 501 (-3.4A)
 0.20A 4mwzA-5wp5A:
33.6		 4mwzA-5wp5A:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_B_SAMB301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 4 SER A 264
ASP A 312
MET A 317
ASP A 338
 SAH  A 501 (-2.6A)
SAH  A 501 (-2.8A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.4A)
 0.63A 4mwzB-5wp5A:
32.8		 4mwzB-5wp5A:
31.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 292
SER A 314
MET A 317
HIS A 360
 SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
SAH  A 501 (-4.0A)
 0.71A 4qdjA-5wp5A:
16.1		 4qdjA-5wp5A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 292
GLY A 294
LEU A 313
THR A 340
 SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-3.9A)
SAH  A 501 ( 4.5A)
 0.80A 4uckA-5wp5A:
7.2		 4uckA-5wp5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 5 PHE A  67
PHE A 155
PHE A 124
VAL A  45
 SAH  A 502 (-4.6A)
None
None
None
 1.09A 5a1rA-5wp5A:
undetectable		 5a1rA-5wp5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 6 ILE A 361
LEU A 367
TYR A 414
THR A 384
 None
 1.03A 5b1aN-5wp5A:
1.4
5b1aW-5wp5A:
undetectable		 5b1aN-5wp5A:
20.45
5b1aW-5wp5A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 4 ASP A 288
GLY A 292
ASP A 312
ASP A 338
 SAH  A 501 ( 4.4A)
SAH  A 501 (-3.6A)
SAH  A 501 (-2.8A)
SAH  A 501 (-3.4A)
 0.51A 5e72A-5wp5A:
14.8		 5e72A-5wp5A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 5 ALA A 413
GLY A 484
CYH A 387
LYS A 482
 None
 1.02A 5jliA-5wp5A:
undetectable		 5jliA-5wp5A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 5 ALA A 413
GLY A 484
CYH A 387
LYS A 482
 None
 0.94A 5jt4A-5wp5A:
undetectable		 5jt4A-5wp5A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A  63
ASP A 107
VAL A 108
THR A 109
LEU A 128
 SAH  A 502 (-3.5A)
SAH  A 502 (-3.2A)
SAH  A 502 (-3.6A)
SAH  A 502 ( 4.8A)
None
 0.69A 5kocA-5wp5A:
22.1		 5kocA-5wp5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A  61
GLY A  63
ASP A 107
VAL A 108
THR A 109
 SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.2A)
SAH  A 502 (-3.6A)
SAH  A 502 ( 4.8A)
 0.68A 5kpcB-5wp5A:
21.9		 5kpcB-5wp5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		6 / 12 SER A 264
GLY A 290
GLY A 292
SER A 314
ASP A 338
THR A 340
 SAH  A 501 (-2.6A)
SAH  A 501 (-3.8A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-3.4A)
SAH  A 501 ( 4.5A)
 0.88A 5kpcB-5wp5A:
21.9		 5kpcB-5wp5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 6 LEU A  81
ALA A  62
LEU A  60
SER A 125
 None
 1.23A 5l4iB-5wp5A:
undetectable		 5l4iB-5wp5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 MET A 130
SER A 125
GLU A  59
VAL A  45
PHE A  67
 None
None
None
None
SAH  A 502 (-4.6A)
 1.40A 5vlmB-5wp5A:
undetectable		 5vlmB-5wp5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 MET A 130
SER A 125
GLU A  59
VAL A  45
PHE A  67
 None
None
None
None
SAH  A 502 (-4.6A)
 1.45A 5vlmH-5wp5A:
1.1		 5vlmH-5wp5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		6 / 12 GLY A  61
GLY A  63
ASP A  82
VAL A 108
LEU A 128
LEU A 132
 SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-2.9A)
SAH  A 502 (-3.6A)
None
None
 0.56A 5wy0A-5wp5A:
14.4		 5wy0A-5wp5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 296
LEU A 313
ASP A 338
CYH A 339
 SAH  A 501 (-3.8A)
None
SAH  A 501 (-3.9A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.5A)
 0.73A 5yn6A-5wp5A:
undetectable		 5yn6A-5wp5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		6 / 12 GLY A 290
GLY A 296
ASP A 312
LEU A 313
ASP A 338
CYH A 339
 SAH  A 501 (-3.8A)
None
SAH  A 501 (-2.8A)
SAH  A 501 (-3.9A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.5A)
 0.73A 5yniA-5wp5A:
7.8		 5yniA-5wp5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		6 / 12 GLY A 290
GLY A 296
ASP A 312
LEU A 313
ASP A 338
CYH A 339
 SAH  A 501 (-3.8A)
None
SAH  A 501 (-2.8A)
SAH  A 501 (-3.9A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.5A)
 0.77A 5ynmA-5wp5A:
8.7		 5ynmA-5wp5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2
(Arabidopsis
thaliana) 		4 / 5 TYR A 414
GLY A 415
HIS A 409
ASP A 407
 None
 1.25A 6gh9A-5wp5A:
undetectable		 6gh9A-5wp5A:
9.65