SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wp6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		4 / 7 ILE A1066
ARG A1062
TYR A1063
PHE A 667
 None
 0.92A 1e71M-5wp6A:
undetectable		 1e71M-5wp6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		4 / 7 ILE A1066
ARG A1062
TYR A1063
PHE A 667
 None
 0.95A 1e72M-5wp6A:
undetectable		 1e72M-5wp6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		5 / 11 LEU A 952
GLU A 981
ALA A1008
SER A 961
VAL A1012
 None
 1.26A 1ictA-5wp6A:
undetectable
1ictC-5wp6A:
undetectable		 1ictA-5wp6A:
21.55
1ictC-5wp6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		5 / 12 LEU A 138
ALA A 169
ASN A 228
ALA A 185
ALA A 146
 None
 1.12A 1sa1A-5wp6A:
3.0
1sa1B-5wp6A:
3.2		 1sa1A-5wp6A:
11.65
1sa1B-5wp6A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		5 / 12 LEU A 138
ALA A 169
ASN A 228
ALA A 185
ALA A 146
 None
 1.15A 1sa1C-5wp6A:
3.0
1sa1D-5wp6A:
undetectable		 1sa1C-5wp6A:
11.65
1sa1D-5wp6A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		3 / 3 TRP A 152
THR A 107
TYR A 103
 None
 1.04A 2a3aA-5wp6A:
undetectable		 2a3aA-5wp6A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		3 / 3 TRP A 152
THR A 107
TYR A 103
 None
 1.04A 2a3aB-5wp6A:
undetectable		 2a3aB-5wp6A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		3 / 3 TRP A 152
THR A 107
TYR A 103
 None
 1.00A 2a3bA-5wp6A:
undetectable		 2a3bA-5wp6A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		4 / 5 VAL A 102
LYS A  18
LYS A  16
PHE A  15
 None
 1.22A 3rv5C-5wp6A:
undetectable
3rv5D-5wp6A:
undetectable		 3rv5C-5wp6A:
undetectable
3rv5D-5wp6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		5 / 9 ALA A 307
GLY A 126
ILE A 162
GLY A 123
ILE A 278
 None
 1.10A 4eatB-5wp6A:
undetectable		 4eatB-5wp6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		3 / 3 LYS A  17
ARG A  92
TRP A 191
 None
 1.48A 4i90A-5wp6A:
undetectable		 4i90A-5wp6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		3 / 3 ARG A1064
LEU A1065
GLU A1068
 None
 0.70A 4l3gF-5wp6A:
undetectable		 4l3gF-5wp6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		3 / 3 SER A 366
ALA A 302
VAL A 301
 None
 0.62A 4o2bA-5wp6A:
2.6		 4o2bA-5wp6A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		5 / 11 LEU A 642
SER A 587
LEU A 590
LEU A 641
LEU A 655
 None
 1.32A 4or0A-5wp6A:
undetectable		 4or0A-5wp6A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		5 / 11 LEU A 642
SER A 587
LEU A 590
LEU A 641
LEU A 655
 None
 1.26A 4or0B-5wp6A:
undetectable		 4or0B-5wp6A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		4 / 7 PHE A 936
TRP A 940
ALA A1031
LEU A1035
 None
 1.07A 4xk8A-5wp6A:
undetectable		 4xk8A-5wp6A:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		4 / 4 LEU A 138
ILE A 162
HIS A 165
VAL A 166
 None
 1.24A 4xyzA-5wp6A:
undetectable		 4xyzA-5wp6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		5 / 12 LEU A 564
LEU A 657
GLY A 591
ALA A 592
LEU A 596
 None
 1.09A 5ikqA-5wp6A:
undetectable		 5ikqA-5wp6A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		5 / 12 LEU A 564
LEU A 657
GLY A 591
ALA A 592
LEU A 596
 None
 1.11A 5ikqB-5wp6A:
undetectable		 5ikqB-5wp6A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wp6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4
(Homo
sapiens) 		4 / 5 TYR A 229
GLY A 187
GLY A 303
LEU A 142
 None
 0.86A 5jlcA-5wp6A:
undetectable		 5jlcA-5wp6A:
9.85