SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wpb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5wpb HISTONE DEACETYLASE
6
(Homo
sapiens) 		5 / 9 VAL A1190
VAL A1119
LEU A1172
ALA A1194
LEU A1195
 None
 1.08A 1eqgA-5wpbA:
undetectable		 1eqgA-5wpbA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5wpb HISTONE DEACETYLASE
6
(Homo
sapiens) 		5 / 11 VAL A1190
VAL A1119
LEU A1172
ALA A1194
LEU A1195
 None
 1.07A 1eqgB-5wpbA:
undetectable		 1eqgB-5wpbA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5wpb HISTONE DEACETYLASE
6
(Homo
sapiens) 		5 / 12 VAL A1190
VAL A1119
LEU A1172
ALA A1194
LEU A1195
 None
 1.06A 3n8zA-5wpbA:
undetectable		 3n8zA-5wpbA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wpb HISTONE DEACETYLASE
6
(Homo
sapiens) 		5 / 12 VAL A1190
VAL A1119
LEU A1172
ALA A1194
LEU A1195
 None
 1.05A 3rr3A-5wpbA:
undetectable		 3rr3A-5wpbA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wpb HISTONE DEACETYLASE
6
(Homo
sapiens) 		5 / 12 VAL A1190
VAL A1119
LEU A1172
ALA A1194
LEU A1195
 None
 1.04A 3rr3B-5wpbA:
undetectable		 3rr3B-5wpbA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wpb HISTONE DEACETYLASE
6
(Homo
sapiens) 		5 / 10 VAL A1190
VAL A1119
LEU A1172
ALA A1194
LEU A1195
 None
 1.00A 4ph9A-5wpbA:
undetectable		 4ph9A-5wpbA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wpb HISTONE DEACETYLASE
6
(Homo
sapiens) 		5 / 10 VAL A1190
VAL A1119
LEU A1172
ALA A1194
LEU A1195
 None
 0.99A 4ph9B-5wpbA:
undetectable		 4ph9B-5wpbA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 5wpb HISTONE DEACETYLASE
6
(Homo
sapiens) 		3 / 3 HIS A1203
LYS A1206
PHE A1207
 None
 1.24A 5klaA-5wpbA:
undetectable		 5klaA-5wpbA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5wpb HISTONE DEACETYLASE
6
(Homo
sapiens) 		3 / 3 VAL A1144
TYR A1149
GLN A1150
 None
None
UNX  A1306 ( 4.7A)
 0.71A 5qgkA-5wpbA:
undetectable		 5qgkA-5wpbA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5wpb HISTONE DEACETYLASE
6
(Homo
sapiens) 		3 / 3 VAL A1144
TYR A1149
GLN A1150
 None
None
UNX  A1306 ( 4.7A)
 0.69A 5qgrA-5wpbA:
undetectable		 5qgrA-5wpbA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5wpb HISTONE DEACETYLASE
6
(Homo
sapiens) 		3 / 3 VAL A1144
TYR A1149
GLN A1150
 None
None
UNX  A1306 ( 4.7A)
 0.70A 5qgtA-5wpbA:
undetectable		 5qgtA-5wpbA:
19.34