SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wpi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 9 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.41A 1bkfA-5wpiA:
undetectable		 1bkfA-5wpiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 11 PHE A  58
VAL A  40
ILE A  38
ILE A  73
PHE A 345
 PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
ILE  A  73 ( 0.6A)
PHE  A 345 ( 1.3A)
 1.25A 2dg3A-5wpiA:
undetectable		 2dg3A-5wpiA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 11 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.31A 2dg3A-5wpiA:
undetectable		 2dg3A-5wpiA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 12 PRO A  17
ALA A 352
ALA A 119
PHE A 149
ILE A 152
 PRO  A  17 ( 1.1A)
ALA  A 352 ( 0.0A)
ALA  A 119 ( 0.0A)
PHE  A 149 ( 1.3A)
ILE  A 152 ( 0.6A)
 1.30A 2jjpA-5wpiA:
undetectable		 2jjpA-5wpiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 12 ILE A  38
ALA A 119
ILE A  51
PRO A  52
ASN A  55
 ILE  A  38 ( 0.7A)
ALA  A 119 ( 0.0A)
ILE  A  51 ( 0.7A)
PRO  A  52 ( 1.1A)
ASN  A  55 ( 0.6A)
 1.01A 2w3mA-5wpiA:
undetectable		 2w3mA-5wpiA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 12 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.34A 4drhA-5wpiA:
undetectable		 4drhA-5wpiA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 12 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.29A 4drhD-5wpiA:
undetectable		 4drhD-5wpiA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 11 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.29A 4driA-5wpiA:
undetectable		 4driA-5wpiA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 11 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.33A 4drjA-5wpiA:
undetectable		 4drjA-5wpiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5wpi HSVA
(Erwinia
amylovora) 		4 / 7 ASP A 251
ASP A 203
GLU A 244
ASP A 123
 ASP  A 251 ( 0.6A)
ASP  A 203 ( 0.5A)
GLU  A 244 ( 0.6A)
ASP  A 123 ( 0.6A)
 1.19A 4feuB-5wpiA:
undetectable		 4feuB-5wpiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5wpi HSVA
(Erwinia
amylovora) 		4 / 7 ASP A  36
PRO A  96
HIS A 101
SER A  99
 ASP  A  36 ( 0.6A)
PRO  A  96 ( 1.1A)
HIS  A 101 ( 1.0A)
SER  A  99 ( 0.0A)
 1.16A 4k7gB-5wpiA:
undetectable		 4k7gB-5wpiA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wpi HSVA
(Erwinia
amylovora) 		4 / 5 LEU A 354
PRO A 121
LEU A 125
ILE A 132
 LEU  A 354 ( 0.6A)
PRO  A 121 ( 1.1A)
LEU  A 125 ( 0.5A)
ILE  A 132 ( 0.6A)
 0.92A 4klrA-5wpiA:
undetectable		 4klrA-5wpiA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 10 TYR A 296
PHE A  58
VAL A  40
ILE A  38
LYS A  74
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
LYS  A  74 ( 0.0A)
 1.20A 4laxA-5wpiA:
undetectable		 4laxA-5wpiA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 10 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.43A 4laxA-5wpiA:
undetectable		 4laxA-5wpiA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 10 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.37A 4qt2A-5wpiA:
undetectable		 4qt2A-5wpiA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 10 TYR A 296
PHE A  58
VAL A  40
ILE A  38
PHE A 345
 TYR  A 296 ( 1.3A)
PHE  A  58 ( 1.3A)
VAL  A  40 ( 0.5A)
ILE  A  38 ( 0.7A)
PHE  A 345 ( 1.3A)
 1.35A 4qt3A-5wpiA:
undetectable		 4qt3A-5wpiA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5wpi HSVA
(Erwinia
amylovora) 		4 / 6 TRP A 279
PRO A 256
ILE A 128
VAL A  20
 TRP  A 279 ( 0.5A)
PRO  A 256 ( 1.1A)
ILE  A 128 ( 0.7A)
VAL  A  20 ( 0.6A)
 0.94A 4zj8A-5wpiA:
undetectable		 4zj8A-5wpiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 10 PRO A 273
ILE A 212
MET A 207
VAL A 262
ILE A 366
 PRO  A 273 ( 1.1A)
ILE  A 212 ( 0.6A)
MET  A 207 ( 0.0A)
VAL  A 262 ( 0.6A)
ILE  A 366 ( 0.7A)
 1.40A 5mzrA-5wpiA:
undetectable		 5mzrA-5wpiA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 10 PRO A 273
ILE A 212
MET A 207
VAL A 262
ILE A 366
 PRO  A 273 ( 1.1A)
ILE  A 212 ( 0.6A)
MET  A 207 ( 0.0A)
VAL  A 262 ( 0.6A)
ILE  A 366 ( 0.7A)
 1.40A 5mzrC-5wpiA:
undetectable		 5mzrC-5wpiA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5wpi HSVA
(Erwinia
amylovora) 		5 / 9 PRO A 273
ILE A 212
MET A 207
VAL A 262
ILE A 366
 PRO  A 273 ( 1.1A)
ILE  A 212 ( 0.6A)
MET  A 207 ( 0.0A)
VAL  A 262 ( 0.6A)
ILE  A 366 ( 0.7A)
 1.42A 5mzrD-5wpiA:
undetectable		 5mzrD-5wpiA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 5wpi HSVA
(Erwinia
amylovora) 		4 / 8 HIS A  56
HIS A 217
TRP A 176
TRP A 139
 HIS  A  56 ( 1.0A)
HIS  A 217 ( 1.0A)
TRP  A 176 ( 0.5A)
TRP  A 139 ( 0.5A)
 1.13A 5yj1k-5wpiA:
undetectable
5yj1t-5wpiA:
undetectable		 5yj1k-5wpiA:
12.05
5yj1t-5wpiA:
12.05