SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A  75
ILE A 354
VAL A 219
SER A 346
LEU A 342
 None
 1.23A 1fm4A-5wpkA:
3.9		 1fm4A-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		4 / 8 GLU A  81
ASN A 267
ALA A 368
LEU A 369
 HMG  A 500 (-3.8A)
HMG  A 500 (-3.8A)
HMG  A 500 ( 3.7A)
HMG  A 500 (-4.7A)
 0.40A 1hwiB-5wpkA:
28.7		 1hwiB-5wpkA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		4 / 8 GLU A  81
ASN A 267
ALA A 368
LEU A 369
 HMG  A 500 (-3.8A)
HMG  A 500 (-3.8A)
HMG  A 500 ( 3.7A)
HMG  A 500 (-4.7A)
 0.39A 1hwiC-5wpkA:
28.9		 1hwiC-5wpkA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 182
ALA A 183
ILE A 209
GLY A 112
ILE A 111
 GOL  A 501 (-3.3A)
GOL  A 501 (-4.0A)
None
None
None
 0.88A 2hs1B-5wpkA:
undetectable		 2hs1B-5wpkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 265
ALA A 271
GLY A 358
VAL A  63
ASN A 267
 None
None
None
None
HMG  A 500 (-3.8A)
 1.09A 2okcA-5wpkA:
undetectable		 2okcA-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 265
ALA A 271
GLY A 358
VAL A  63
ASN A 267
 None
None
None
None
HMG  A 500 (-3.8A)
 1.06A 2okcB-5wpkA:
undetectable		 2okcB-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		3 / 3 ARG A  30
ARG A 334
PRO A 333
 None
 1.01A 2wljA-5wpkA:
undetectable		 2wljA-5wpkA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 SER A  92
ALA A  88
GLY A 268
GLY A 358
VAL A  63
 None
 1.13A 3f8wA-5wpkA:
undetectable		 3f8wA-5wpkA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 SER A  92
ALA A  88
GLY A 268
GLY A 358
VAL A  63
 None
 1.12A 3f8wC-5wpkA:
undetectable		 3f8wC-5wpkA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		4 / 8 GLY A 277
VAL A 335
ILE A 272
VAL A 322
 None
 0.79A 3fi0Q-5wpkA:
undetectable		 3fi0Q-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 TYR A  77
VAL A  63
PRO A  64
ILE A 274
ILE A 269
 None
 1.45A 3ganA-5wpkA:
undetectable		 3ganA-5wpkA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 10 TYR A  73
ILE A 357
VAL A  66
SER A  92
ILE A  95
 None
 1.44A 3uprA-5wpkA:
undetectable		 3uprA-5wpkA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 10 TYR A  73
ILE A 357
VAL A  66
SER A  92
ILE A  95
 None
 1.44A 3uprC-5wpkA:
undetectable		 3uprC-5wpkA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A  75
ILE A 354
VAL A 219
SER A 346
LEU A 342
 None
 1.22A 4a84A-5wpkA:
3.7		 4a84A-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A  62
ILE A 353
ILE A 357
VAL A  66
 None
 0.86A 4ojbA-5wpkA:
undetectable		 4ojbA-5wpkA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		4 / 8 PHE A 363
ALA A 365
HIS A 261
LEU A 359
 None
HMG  A 500 (-3.3A)
None
None
 1.11A 5dzkF-5wpkA:
undetectable
5dzkT-5wpkA:
undetectable		 5dzkF-5wpkA:
undetectable
5dzkT-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 PRO A 122
LYS A 123
ILE A 129
ALA A 130
GLY A 203
 None
 0.76A 5j2tC-5wpkA:
undetectable		 5j2tC-5wpkA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		4 / 6 ILE A 274
TYR A  77
VAL A  78
SER A 338
 None
 1.00A 5jwaH-5wpkA:
undetectable		 5jwaH-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE
(Streptococcus
pneumoniae) 		5 / 10 TYR A  73
ILE A 357
VAL A  66
SER A  92
ILE A  95
 None
 1.45A 5u98D-5wpkA:
undetectable		 5u98D-5wpkA:
15.61