SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		4 / 6 VAL A   9
VAL A  51
ILE A  61
ASN A 268
 None
 0.92A 1e06A-5wq6A:
undetectable		 1e06A-5wq6A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 9 LEU A 300
ALA A 304
LEU A 263
LEU A 286
GLU A 289
 None
 1.44A 1sn0A-5wq6A:
undetectable
1sn0C-5wq6A:
undetectable		 1sn0A-5wq6A:
16.12
1sn0C-5wq6A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 11 VAL A 459
ALA A 370
ILE A 179
ALA A 373
ASP A 178
 None
 1.27A 2admB-5wq6A:
undetectable		 2admB-5wq6A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 11 THR A  94
GLN A 326
ALA A 325
ALA A 304
ALA A 302
 None
 1.19A 2f16H-5wq6A:
undetectable
2f16I-5wq6A:
undetectable		 2f16H-5wq6A:
20.54
2f16I-5wq6A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 11 THR A  94
GLN A 326
ALA A 325
ALA A 304
ALA A 302
 None
 1.18A 2f16V-5wq6A:
undetectable
2f16W-5wq6A:
undetectable		 2f16V-5wq6A:
20.54
2f16W-5wq6A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 12 LEU A 263
ILE A 109
VAL A  98
LEU A  77
ILE A  80
 None
 1.08A 2h42C-5wq6A:
undetectable		 2h42C-5wq6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		4 / 8 THR A  94
LEU A 286
ASP A 288
GLU A 112
 None
None
None
MAL  A 501 (-2.9A)
 1.08A 2zw9A-5wq6A:
undetectable		 2zw9A-5wq6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 12 LEU A 193
THR A 194
ALA A 347
THR A 346
ILE A 349
 None
 1.23A 3a35A-5wq6A:
undetectable		 3a35A-5wq6A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		4 / 7 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.71A 3bjwC-5wq6A:
undetectable		 3bjwC-5wq6A:
12.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		10 / 12 ASP A  15
LYS A  16
LYS A  43
GLU A  45
GLU A  46
ALA A  64
ASP A  66
ARG A  67
GLU A 112
TRP A 231
 MAL  A 501 (-2.9A)
MAL  A 501 (-2.8A)
None
EDO  A 503 (-2.9A)
None
MAL  A 501 (-3.3A)
MAL  A 501 (-2.8A)
MAL  A 501 (-3.9A)
MAL  A 501 (-2.9A)
MAL  A 501 ( 4.5A)
 0.75A 3jyrA-5wq6A:
63.3		 3jyrA-5wq6A:
76.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		10 / 12 ASP A  15
LYS A  16
LYS A  43
GLU A  45
GLU A  46
ALA A  64
ASP A  66
GLU A 112
PRO A 155
TRP A 231
 MAL  A 501 (-2.9A)
MAL  A 501 (-2.8A)
None
EDO  A 503 (-2.9A)
None
MAL  A 501 (-3.3A)
MAL  A 501 (-2.8A)
MAL  A 501 (-2.9A)
MAL  A 501 (-3.4A)
MAL  A 501 ( 4.5A)
 0.42A 3jyrA-5wq6A:
63.3		 3jyrA-5wq6A:
76.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		6 / 7 ASN A  13
TRP A  63
GLU A 154
TYR A 156
MET A 331
TRP A 341
 EDO  A 503 (-3.4A)
MAL  A 501 (-4.5A)
MAL  A 501 (-3.7A)
MAL  A 501 (-3.8A)
MAL  A 501 (-4.4A)
MAL  A 501 (-3.7A)
 0.18A 3jyrA-5wq6A:
63.3		 3jyrA-5wq6A:
76.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 11 GLN A  50
ALA A 270
GLY A  55
THR A  54
ALA A  53
 None
 1.19A 3mg0H-5wq6A:
undetectable
3mg0I-5wq6A:
undetectable		 3mg0H-5wq6A:
20.54
3mg0I-5wq6A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 12 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.99A 3n8yB-5wq6A:
0.0		 3n8yB-5wq6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 12 VAL A 344
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 1.32A 3pghA-5wq6A:
undetectable		 3pghA-5wq6A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 501 (-2.9A)
None
 0.84A 3tbgB-5wq6A:
undetectable		 3tbgB-5wq6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 501 (-2.9A)
None
 0.83A 3tbgD-5wq6A:
undetectable		 3tbgD-5wq6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		4 / 4 LEU A 380
GLY A 383
MET A 422
PHE A 392
 None
 1.37A 3vaqB-5wq6A:
undetectable		 3vaqB-5wq6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 12 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.39A 3vwqA-5wq6A:
undetectable		 3vwqA-5wq6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		4 / 5 GLU A 309
ASP A 315
ASP A 288
ASN A 295
 None
 1.35A 3vywD-5wq6A:
undetectable		 3vywD-5wq6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 12 ILE A 267
ALA A 106
LEU A  21
VAL A  24
ILE A  60
 None
 1.09A 4m2xG-5wq6A:
undetectable		 4m2xG-5wq6A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		4 / 5 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 501 (-2.9A)
 0.93A 4n48A-5wq6A:
undetectable		 4n48A-5wq6A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 9 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.17A 4or0B-5wq6A:
undetectable		 4or0B-5wq6A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 12 VAL A 344
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 1.23A 5iktB-5wq6A:
undetectable		 5iktB-5wq6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 12 GLN A  50
ALA A 270
GLY A  55
THR A  54
ALA A  53
 None
 1.22A 5l66H-5wq6A:
undetectable
5l66I-5wq6A:
undetectable		 5l66H-5wq6A:
21.35
5l66I-5wq6A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 12 GLN A  50
ALA A 270
GLY A  55
THR A  54
ALA A  53
 None
 1.22A 5l66V-5wq6A:
undetectable
5l66W-5wq6A:
undetectable		 5l66V-5wq6A:
21.35
5l66W-5wq6A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		6 / 12 ALA A 343
ALA A 339
GLY A 167
ALA A 189
PHE A 170
VAL A 182
 None
 1.44A 5w4zA-5wq6A:
undetectable		 5w4zA-5wq6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		6 / 12 ALA A 343
ALA A 339
GLY A 167
ALA A 189
PHE A 170
VAL A 182
 None
 1.46A 5w4zB-5wq6A:
undetectable		 5w4zB-5wq6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		3 / 3 TYR A 156
ASN A 228
LEU A 114
 MAL  A 501 (-3.8A)
None
None
 0.82A 6b58A-5wq6A:
undetectable		 6b58A-5wq6A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens) 		5 / 11 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.41A 6bm5A-5wq6A:
undetectable		 6bm5A-5wq6A:
22.51