SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wq7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5wq7 PUTATIVE TYPE II
SECRETION SYSTEM
PROTEIN D
(Escherichia
coli) 		5 / 9 ALA A 366
LEU A 407
GLY A 398
PHE A 400
GLY A 405
 None
 1.43A 1ru9H-5wq7A:
undetectable
1ru9L-5wq7A:
undetectable		 1ru9H-5wq7A:
17.01
1ru9L-5wq7A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5wq7 PUTATIVE TYPE II
SECRETION SYSTEM
PROTEIN D
(Escherichia
coli) 		5 / 10 ALA A 366
LEU A 407
GLY A 398
PHE A 400
GLY A 405
 None
 1.41A 1ruaH-5wq7A:
undetectable
1ruaL-5wq7A:
undetectable		 1ruaH-5wq7A:
17.01
1ruaL-5wq7A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5wq7 PUTATIVE TYPE II
SECRETION SYSTEM
PROTEIN D
(Escherichia
coli) 		3 / 3 ARG A 506
GLU A 333
SER A 495
 None
 0.88A 2xctD-5wq7A:
3.8		 2xctD-5wq7A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5wq7 PUTATIVE TYPE II
SECRETION SYSTEM
PROTEIN D
(Escherichia
coli) 		4 / 6 ARG A 322
ASP A 429
ILE A 570
GLU A 476
 None
 1.44A 2ya7C-5wq7A:
undetectable		 2ya7C-5wq7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5wq7 PUTATIVE TYPE II
SECRETION SYSTEM
PROTEIN D
(Escherichia
coli) 		5 / 11 ILE A 158
ALA A 114
ARG A 122
LEU A 121
ALA A 118
 None
 0.92A 4nqaA-5wq7A:
undetectable		 4nqaA-5wq7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5wq7 PUTATIVE TYPE II
SECRETION SYSTEM
PROTEIN D
(Escherichia
coli) 		4 / 7 ALA A 421
THR A 422
ALA A 329
THR A 466
 None
 0.90A 4qw0K-5wq7A:
undetectable		 4qw0K-5wq7A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5wq7 PUTATIVE TYPE II
SECRETION SYSTEM
PROTEIN D
(Escherichia
coli) 		4 / 7 ALA A 421
THR A 422
ALA A 329
THR A 466
 None
 0.90A 4qw0Y-5wq7A:
undetectable		 4qw0Y-5wq7A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5wq7 PUTATIVE TYPE II
SECRETION SYSTEM
PROTEIN D
(Escherichia
coli) 		4 / 7 LEU A 109
VAL A 141
GLU A 137
VAL A 107
 None
 1.18A 5jh7C-5wq7A:
undetectable		 5jh7C-5wq7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5wq7 PUTATIVE TYPE II
SECRETION SYSTEM
PROTEIN D
(Escherichia
coli) 		5 / 12 ILE A 158
ALA A 114
ILE A 143
LEU A 121
ALA A 118
 None
 0.99A 6a5zD-5wq7A:
undetectable		 6a5zD-5wq7A:
9.94