SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5wq8 TYPE II SECRETION
SYSTEM PROTEIN D
(Vibrio
cholerae) 		4 / 8 LYS A 483
THR A 460
ARG A 477
GLU A 503
 None
 1.37A 1xr2B-5wq8A:
undetectable		 1xr2B-5wq8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5wq8 TYPE II SECRETION
SYSTEM PROTEIN D
(Vibrio
cholerae) 		3 / 3 ARG A 633
ARG A 634
PRO A 627
 None
 0.87A 2wljA-5wq8A:
undetectable		 2wljA-5wq8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5wq8 TYPE II SECRETION
SYSTEM PROTEIN D
(Vibrio
cholerae) 		4 / 4 SER A 567
GLY A 338
GLY A 353
GLY A 356
 None
 0.81A 3bogB-5wq8A:
undetectable
3bogD-5wq8A:
undetectable		 3bogB-5wq8A:
undetectable
3bogD-5wq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5wq8 TYPE II SECRETION
SYSTEM PROTEIN D
(Vibrio
cholerae) 		4 / 5 ASN A 150
ALA A 146
ALA A 147
ARG A 145
 None
 1.33A 3kp2B-5wq8A:
undetectable		 3kp2B-5wq8A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5wq8 TYPE II SECRETION
SYSTEM PROTEIN D
(Vibrio
cholerae) 		4 / 4 ASN A 354
SER A 413
LEU A 422
THR A 568
 None
 1.31A 4an2A-5wq8A:
2.9		 4an2A-5wq8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 5wq8 TYPE II SECRETION
SYSTEM PROTEIN D
(Vibrio
cholerae) 		5 / 12 ALA A 175
ILE A 183
GLN A 231
LEU A 225
ILE A 213
 None
 0.96A 4m2xC-5wq8A:
undetectable		 4m2xC-5wq8A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 5wq8 TYPE II SECRETION
SYSTEM PROTEIN D
(Vibrio
cholerae) 		5 / 12 LEU A 225
LEU A 228
LEU A 172
MET A 180
VAL A 181
 None
 1.16A 4olmA-5wq8A:
undetectable		 4olmA-5wq8A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 5wq8 TYPE II SECRETION
SYSTEM PROTEIN D
(Vibrio
cholerae) 		3 / 3 ASN A 506
ALA A 519
ARG A 521
 None
 0.77A 5cvtB-5wq8A:
undetectable		 5cvtB-5wq8A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5wq8 TYPE II SECRETION
SYSTEM PROTEIN D
(Vibrio
cholerae) 		3 / 3 LYS A 251
ASP A 254
ARG A 317
 None
 1.10A 5jwaA-5wq8A:
undetectable
5jwaH-5wq8A:
undetectable		 5jwaA-5wq8A:
22.09
5jwaH-5wq8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5wq8 TYPE II SECRETION
SYSTEM PROTEIN D
(Vibrio
cholerae) 		3 / 3 ASP A 631
ASN A 601
GLN A 597
 None
 0.75A 5k7uA-5wq8A:
undetectable		 5k7uA-5wq8A:
14.68