SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wqk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 10 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.03A 1pxxA-5wqkA:
undetectable		 1pxxA-5wqkA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 9 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.02A 1pxxB-5wqkA:
undetectable		 1pxxB-5wqkA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.01A 1pxxC-5wqkA:
undetectable		 1pxxC-5wqkA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 10 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.02A 1pxxD-5wqkA:
undetectable		 1pxxD-5wqkA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		4 / 5 LEU A 128
ASP A 101
LEU A  20
HIS A  96
 None
 1.30A 2jfaA-5wqkA:
undetectable		 2jfaA-5wqkA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		4 / 5 LEU A 128
ASP A 101
LEU A  20
HIS A  96
 None
 1.25A 2qxsA-5wqkA:
undetectable		 2qxsA-5wqkA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		4 / 5 LEU A 128
ASP A 101
LEU A  20
HIS A  96
 None
 1.26A 2qxsB-5wqkA:
undetectable		 2qxsB-5wqkA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 12 GLY A 131
GLY A 106
ILE A  54
ASP A 129
LEU A 128
 None
 1.00A 3ihtA-5wqkA:
undetectable		 3ihtA-5wqkA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 6 GLY A 249
VAL A 252
HIS A  74
SER A 250
THR A 253
 7NC  A 301 (-3.5A)
7NC  A 301 ( 4.3A)
7NC  A 301 ( 4.2A)
7NC  A 301 ( 2.8A)
7NC  A 301 ( 4.4A)
 1.26A 3tj7A-5wqkA:
undetectable
3tj7B-5wqkA:
undetectable		 3tj7A-5wqkA:
17.43
3tj7B-5wqkA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 6 GLY A 249
VAL A 252
HIS A  74
SER A 250
THR A 253
 7NC  A 301 (-3.5A)
7NC  A 301 ( 4.3A)
7NC  A 301 ( 4.2A)
7NC  A 301 ( 2.8A)
7NC  A 301 ( 4.4A)
 1.26A 3tj7C-5wqkA:
undetectable
3tj7D-5wqkA:
undetectable		 3tj7C-5wqkA:
17.43
3tj7D-5wqkA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 6 VAL A 252
HIS A  74
SER A 250
THR A 253
GLY A 249
 7NC  A 301 ( 4.3A)
7NC  A 301 ( 4.2A)
7NC  A 301 ( 2.8A)
7NC  A 301 ( 4.4A)
7NC  A 301 (-3.5A)
 1.26A 3tj7C-5wqkA:
undetectable
3tj7D-5wqkA:
undetectable		 3tj7C-5wqkA:
17.43
3tj7D-5wqkA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.13A 4coxC-5wqkA:
undetectable		 4coxC-5wqkA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		4 / 4 SER A  66
ASP A 273
ASP A 182
ASP A  73
 None
NA  A 302 (-3.1A)
None
7NC  A 301 ( 3.6A)
 1.11A 4uciA-5wqkA:
undetectable		 4uciA-5wqkA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		4 / 4 SER A  66
ASP A 273
ASP A 182
ASP A  73
 None
NA  A 302 (-3.1A)
None
7NC  A 301 ( 3.6A)
 1.11A 4uciB-5wqkA:
undetectable		 4uciB-5wqkA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 12 ILE A 229
ALA A 261
ALA A   9
ARG A 118
LEU A 259
 None
 1.36A 4zo1X-5wqkA:
undetectable		 4zo1X-5wqkA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.07A 5ikqA-5wqkA:
undetectable		 5ikqA-5wqkA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.10A 5ikqB-5wqkA:
undetectable		 5ikqB-5wqkA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.11A 5ikrB-5wqkA:
undetectable		 5ikrB-5wqkA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 12 LEU A 232
VAL A 257
GLY A 260
ALA A 261
SER A 264
 None
 1.09A 5kirA-5wqkA:
undetectable		 5kirA-5wqkA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		5 / 12 ILE A 288
HIS A 204
SER A 208
HIS A 287
LEU A 173
 None
 1.46A 6chgC-5wqkA:
undetectable		 6chgC-5wqkA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5wqk SULFURTRANSFERASE
(Mus
musculus) 		3 / 3 ALA A 185
PHE A 213
GLN A 105
 None
 0.67A 6eceA-5wqkA:
undetectable		 6eceA-5wqkA:
22.90