SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wqn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A  58
GLY A   8
PRO A 113
ALA A 112
 None
 0.92A 2aohA-5wqnA:
undetectable		 2aohA-5wqnA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 220
LEU A 204
SER A 134
MET A 133
ILE A  81
 None
 1.19A 2zbzA-5wqnA:
undetectable		 2zbzA-5wqnA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  17
GLY A   8
GLY A  14
ALA A  30
LEU A 116
 None
 1.13A 3dh0A-5wqnA:
7.8		 3dh0A-5wqnA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  17
GLY A   8
GLY A  14
ALA A  30
LEU A 116
 None
 1.08A 3dh0B-5wqnA:
7.6		 3dh0B-5wqnA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  28
GLY A  49
ALA A  48
LEU A  44
LEU A  41
 None
 1.06A 3n8yB-5wqnA:
undetectable		 3n8yB-5wqnA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 138
GLY A 152
LEU A 144
MET A 148
HIS A 180
 None
 1.16A 3pfgA-5wqnA:
7.9		 3pfgA-5wqnA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 130
VAL A 124
ILE A  77
LEU A  59
LEU A 116
 None
 1.50A 4jtqA-5wqnA:
undetectable		 4jtqA-5wqnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  17
PHE A  21
GLY A 203
ALA A 206
ALA A 212
 None
 0.90A 4nkxC-5wqnA:
undetectable		 4nkxC-5wqnA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  17
PHE A  21
GLY A 203
ALA A 206
ALA A 212
 None
 0.92A 4nkxD-5wqnA:
undetectable		 4nkxD-5wqnA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ILE A  86
GLN A 104
ILE A  97
ASP A  98
 None
 1.11A 4w5qA-5wqnA:
3.3		 4w5qA-5wqnA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ILE A  86
GLN A 104
ILE A  97
ASP A  98
 None
 1.19A 4z4cA-5wqnA:
3.2		 4z4cA-5wqnA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ILE A  86
GLN A 104
ILE A  97
ASP A  98
 None
 1.09A 4z4dA-5wqnA:
3.2		 4z4dA-5wqnA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 117
LEU A  80
ILE A  81
GLY A 128
LEU A 172
 None
 1.04A 5m24A-5wqnA:
undetectable		 5m24A-5wqnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  63
CYH A  64
GLY A  57
ALA A  32
VAL A  31
 None
 1.50A 5v3cA-5wqnA:
2.7		 5v3cA-5wqnA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 5wqn PROBABLE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 8 SER A 135
GLN A 136
MET A 137
MET A 148
TYR A 151
HIS A 180
 None
 0.35A 5wqpA-5wqnA:
38.5		 5wqpA-5wqnA:
100.00