SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		4 / 7 GLN A1085
SER A1074
TYR A1067
GLN A 892
 None
None
None
EDO  A1201 ( 4.3A)
 1.48A 1eiiA-5wqwA:
undetectable		 1eiiA-5wqwA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		4 / 8 GLY A1048
THR A1050
VAL A1015
ILE A 986
 None
 0.77A 2a1mB-5wqwA:
undetectable		 2a1mB-5wqwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		5 / 10 ALA A1060
ALA A1059
PHE A 951
ALA A 954
ILE A1107
 None
EDO  A1202 (-4.0A)
None
None
None
 1.14A 2aclC-5wqwA:
undetectable		 2aclC-5wqwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		5 / 9 ASP A 961
ILE A 923
VAL A1068
VAL A1063
GLN A 968
 None
None
None
None
EDO  A1206 (-2.8A)
 1.44A 3fi0R-5wqwA:
undetectable		 3fi0R-5wqwA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		5 / 10 ILE A1090
TYR A 964
ILE A1104
ARG A1082
MET A1081
 EDO  A1201 (-4.8A)
None
None
EDO  A1201 ( 4.4A)
EDO  A1206 (-3.2A)
 1.41A 3ohtA-5wqwA:
undetectable
3ohtB-5wqwA:
undetectable		 3ohtA-5wqwA:
23.74
3ohtB-5wqwA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		5 / 12 LEU A 965
LEU A 944
GLY A 976
THR A 977
SER A 978
 None
 1.17A 3okxA-5wqwA:
undetectable		 3okxA-5wqwA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		5 / 12 LEU A 965
LEU A 944
GLY A 976
THR A 977
SER A 978
 None
 1.16A 3okxB-5wqwA:
undetectable		 3okxB-5wqwA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		3 / 3 TYR A1018
THR A1016
GLU A1053
 None
 0.81A 4df3A-5wqwA:
undetectable		 4df3A-5wqwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		3 / 3 TYR A1018
THR A1016
GLU A1053
 None
 0.78A 4df3B-5wqwA:
undetectable		 4df3B-5wqwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		4 / 8 PHE A1021
ASN A1019
ALA A1055
LEU A 944
 EDO  A1202 (-4.7A)
EDO  A1202 (-3.7A)
EDO  A1202 (-3.6A)
None
 0.89A 4ejgB-5wqwA:
undetectable		 4ejgB-5wqwA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		4 / 7 PHE A1021
ASN A1019
ALA A1055
LEU A 944
 EDO  A1202 (-4.7A)
EDO  A1202 (-3.7A)
EDO  A1202 (-3.6A)
None
 0.87A 4ejgC-5wqwA:
undetectable		 4ejgC-5wqwA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		4 / 6 PHE A1021
ASN A1019
ALA A1055
LEU A 944
 EDO  A1202 (-4.7A)
EDO  A1202 (-3.7A)
EDO  A1202 (-3.6A)
None
 0.83A 4ejgD-5wqwA:
undetectable		 4ejgD-5wqwA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		4 / 5 ILE A 963
PRO A 962
HIS A1069
TYR A1094
 None
None
None
EDO  A1206 ( 3.9A)
 1.31A 4s0vA-5wqwA:
undetectable		 4s0vA-5wqwA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		5 / 12 CYH A 969
LEU A 970
LEU A1020
ALA A 954
ALA A1059
 None
None
EDO  A1202 (-3.8A)
None
EDO  A1202 (-4.0A)
 0.88A 4x20B-5wqwA:
undetectable		 4x20B-5wqwA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		4 / 5 GLN A 968
ILE A1104
ILE A1107
TYR A1100
 EDO  A1206 (-2.8A)
None
None
EDO  A1206 (-4.2A)
 1.11A 5dnuA-5wqwA:
undetectable		 5dnuA-5wqwA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		4 / 5 GLN A 968
ILE A1104
ILE A1107
TYR A1100
 EDO  A1206 (-2.8A)
None
None
EDO  A1206 (-4.2A)
 1.05A 5dnvA-5wqwA:
undetectable		 5dnvA-5wqwA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 5wqw N-ACETYLGLUCOSAMINID
ASE
(Clostridium
perfringens) 		5 / 12 LEU A 970
ASN A 975
LEU A 944
GLY A 942
LEU A 934
 None
 0.99A 5uc1B-5wqwA:
undetectable		 5uc1B-5wqwA:
13.69