SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wrk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		3 / 3 GLU A 172
TYR A 205
PHE A 174
 None
NI  A 502 (-4.8A)
NI  A 502 ( 4.0A)
 0.75A 1eqbB-5wrkA:
undetectable		 1eqbB-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		3 / 3 GLU A 172
TYR A 205
PHE A 174
 None
NI  A 502 (-4.8A)
NI  A 502 ( 4.0A)
 0.75A 1eqbA-5wrkA:
undetectable		 1eqbA-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		3 / 3 GLU A 172
TYR A 205
PHE A 174
 None
NI  A 502 (-4.8A)
NI  A 502 ( 4.0A)
 0.75A 1eqbD-5wrkA:
undetectable		 1eqbD-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		3 / 3 GLU A 172
TYR A 205
PHE A 174
 None
NI  A 502 (-4.8A)
NI  A 502 ( 4.0A)
 0.75A 1eqbC-5wrkA:
undetectable		 1eqbC-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		3 / 3 VAL A 406
GLU A 408
GLU A 211
 None
 0.79A 2nv4A-5wrkA:
undetectable		 2nv4A-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 12 ILE A 263
ILE A 220
MET A 216
PHE A 214
VAL A 177
 None
 1.08A 2ygnA-5wrkA:
2.0		 2ygnA-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 11 ALA A 317
LEU A 316
PHE A 394
GLY A 360
SER A 309
 None
 1.15A 3bpxA-5wrkA:
undetectable
3bpxB-5wrkA:
undetectable		 3bpxA-5wrkA:
15.54
3bpxB-5wrkA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 10 ILE A 263
PHE A 265
VAL A 401
MET A 202
LEU A 404
 None
 1.26A 3eqmA-5wrkA:
undetectable		 3eqmA-5wrkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 11 ARG A 323
VAL A 392
PRO A 393
PRO A 286
ILE A 307
 None
 1.30A 3ganA-5wrkA:
undetectable		 3ganA-5wrkA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		4 / 8 ILE A 366
ALA A 350
THR A 326
VAL A 335
 None
 0.84A 3me6B-5wrkA:
undetectable		 3me6B-5wrkA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 12 ILE A 263
PHE A 265
VAL A 401
MET A 202
LEU A 404
 None
 1.27A 3s79A-5wrkA:
undetectable		 3s79A-5wrkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 12 CYH A 337
ILE A 355
SER A 364
ILE A 324
ALA A 350
 None
 1.23A 3vw1D-5wrkA:
undetectable		 3vw1D-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		3 / 3 LYS A 312
PRO A 313
SER A 314
 None
 0.44A 4k50I-5wrkA:
undetectable		 4k50I-5wrkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		4 / 6 ILE A 307
GLY A 189
MET A 185
ILE A 290
 None
 0.98A 5j4nB-5wrkA:
undetectable		 5j4nB-5wrkA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 11 ILE A 263
PHE A 265
VAL A 401
MET A 202
LEU A 404
 None
 1.20A 5jkwA-5wrkA:
undetectable		 5jkwA-5wrkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 10 ILE A 263
PHE A 265
VAL A 401
MET A 202
LEU A 404
 None
 1.20A 5jl7A-5wrkA:
undetectable		 5jl7A-5wrkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5wrk AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		4 / 6 ASN A 182
PRO A 396
VAL A 196
TYR A 431
 None
 1.11A 5umd2-5wrkA:
undetectable
5umdF-5wrkA:
undetectable		 5umd2-5wrkA:
19.39
5umdF-5wrkA:
12.35