SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wrl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		3 / 3 GLU A 172
TYR A 205
PHE A 174
 None
 0.78A 1eqbB-5wrlA:
undetectable		 1eqbB-5wrlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		3 / 3 GLU A 172
TYR A 205
PHE A 174
 None
 0.78A 1eqbA-5wrlA:
undetectable		 1eqbA-5wrlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		3 / 3 GLU A 172
TYR A 205
PHE A 174
 None
 0.78A 1eqbD-5wrlA:
undetectable		 1eqbD-5wrlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		3 / 3 GLU A 172
TYR A 205
PHE A 174
 None
 0.77A 1eqbC-5wrlA:
undetectable		 1eqbC-5wrlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 12 ILE A 266
LEU A 404
LEU A 173
CYH A 251
LEU A 206
 None
 1.25A 2bxfA-5wrlA:
undetectable		 2bxfA-5wrlA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		6 / 12 LEU A 206
ILE A 263
ILE A 243
MET A 216
PHE A 214
VAL A 177
 None
 1.33A 2ygnA-5wrlA:
undetectable		 2ygnA-5wrlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 11 ALA A 317
LEU A 316
PHE A 394
GLY A 360
SER A 309
 None
 1.20A 3bpxA-5wrlA:
undetectable
3bpxB-5wrlA:
undetectable		 3bpxA-5wrlA:
18.49
3bpxB-5wrlA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 10 ILE A 263
PHE A 265
VAL A 401
MET A 202
LEU A 404
 None
 1.34A 3eqmA-5wrlA:
undetectable		 3eqmA-5wrlA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		6 / 11 ARG A 323
GLN A 318
VAL A 392
PRO A 393
PRO A 286
ILE A 307
 None
 1.40A 3ganA-5wrlA:
undetectable		 3ganA-5wrlA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 11 ILE A 263
PHE A 265
VAL A 401
MET A 202
LEU A 404
 None
 1.28A 5jkwA-5wrlA:
undetectable		 5jkwA-5wrlA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		5 / 10 ILE A 263
PHE A 265
VAL A 401
MET A 202
LEU A 404
 None
 1.30A 5jl7A-5wrlA:
undetectable		 5jl7A-5wrlA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		4 / 6 ASN A 182
PRO A 396
VAL A 196
TYR A 431
 None
 1.12A 5umd2-5wrlA:
undetectable
5umdF-5wrlA:
undetectable		 5umd2-5wrlA:
23.00
5umdF-5wrlA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		3 / 3 ARG A 162
PHE A 407
LEU A 206
 None
 0.47A 5x1bC-5wrlA:
undetectable		 5x1bC-5wrlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5wrl AP-2 COMPLEX SUBUNIT
MU
(Rattus
norvegicus) 		4 / 7 VAL A 177
VAL A 196
PRO A 396
GLY A 398
 None
 1.00A 5x80C-5wrlA:
undetectable
5x80D-5wrlA:
undetectable		 5x80C-5wrlA:
19.02
5x80D-5wrlA:
19.02