SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5wro ENOLASE
(Drosophila
melanogaster) 		4 / 4 SER A 182
VAL A  89
PHE A 448
VAL A 412
 None
 1.46A 1o86A-5wroA:
undetectable		 1o86A-5wroA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5wro ENOLASE
(Drosophila
melanogaster) 		4 / 7 TYR A 475
ILE A 237
PRO A 239
ALA A 248
 None
 1.01A 1oniD-5wroA:
undetectable
1oniE-5wroA:
undetectable		 1oniD-5wroA:
16.36
1oniE-5wroA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5wro ENOLASE
(Drosophila
melanogaster) 		5 / 11 ILE A 422
LEU A 183
LEU A 197
ILE A 201
ILE A 449
 None
 1.05A 2w9sA-5wroA:
undetectable		 2w9sA-5wroA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5wro ENOLASE
(Drosophila
melanogaster) 		5 / 11 ILE A 422
LEU A 183
LEU A 197
ILE A 201
ILE A 449
 None
 1.07A 2w9sB-5wroA:
undetectable		 2w9sB-5wroA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5wro ENOLASE
(Drosophila
melanogaster) 		4 / 7 VAL A  89
ILE A 157
THR A 419
GLY A 180
 None
 1.03A 3gssA-5wroA:
undetectable		 3gssA-5wroA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5wro ENOLASE
(Drosophila
melanogaster) 		5 / 11 ASP A 158
ASN A 159
ALA A 424
THR A 417
ILE A 415
 None
 1.41A 3n23A-5wroA:
undetectable		 3n23A-5wroA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5wro ENOLASE
(Drosophila
melanogaster) 		5 / 11 MET A 161
ILE A  73
VAL A 181
VAL A  89
ILE A 178
 None
 1.24A 3rf4A-5wroA:
undetectable
3rf4C-5wroA:
undetectable		 3rf4A-5wroA:
18.90
3rf4C-5wroA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 5wro ENOLASE
(Drosophila
melanogaster) 		4 / 4 LEU A 144
GLY A 141
LEU A 140
GLU A 143
 None
 1.06A 3tgvB-5wroA:
undetectable		 3tgvB-5wroA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5wro ENOLASE
(Drosophila
melanogaster) 		4 / 5 ASN A 228
ALA A 281
PRO A 282
ALA A 290
 None
 1.42A 3twpD-5wroA:
undetectable		 3twpD-5wroA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 5wro ENOLASE
(Drosophila
melanogaster) 		5 / 12 LEU A 408
LEU A 409
ILE A 449
ILE A 461
LEU A 456
 None
 1.28A 4j24C-5wroA:
undetectable		 4j24C-5wroA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5wro ENOLASE
(Drosophila
melanogaster) 		5 / 12 LEU A 408
LEU A 409
ILE A 449
ILE A 461
LEU A 456
 None
 1.22A 4j26B-5wroA:
undetectable		 4j26B-5wroA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_C_QI9C602_0
(CYTOCHROME P450 2D6)		 5wro ENOLASE
(Drosophila
melanogaster) 		5 / 9 LEU A 183
ASP A 446
SER A 447
THR A 463
VAL A 412
 None
 1.38A 4wnvC-5wroA:
1.5		 4wnvC-5wroA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 5wro ENOLASE
(Drosophila
melanogaster) 		5 / 12 ALA A 100
ASP A 446
LEU A  91
HIS A 200
LEU A 197
 None
 1.15A 4xi3A-5wroA:
undetectable		 4xi3A-5wroA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFT_A_51GA204_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE (2')-IA)		 5wro ENOLASE
(Drosophila
melanogaster) 		5 / 9 ASP A 362
ASP A 387
LEU A 409
ASP A 386
GLU A 112
 None
None
None
CD  A 602 ( 3.5A)
None
 1.04A 5cftA-5wroA:
0.4		 5cftA-5wroA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5wro ENOLASE
(Drosophila
melanogaster) 		5 / 12 VAL A 313
LEU A 238
ARG A 497
GLY A 385
LEU A 409
 None
 1.28A 5ogcB-5wroA:
undetectable		 5ogcB-5wroA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5wro ENOLASE
(Drosophila
melanogaster) 		3 / 3 LYS A 187
LEU A 179
ASP A 446
 None
 0.87A 5zv2A-5wroA:
undetectable		 5zv2A-5wroA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GZ9_A_TXCA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5wro ENOLASE
(Drosophila
melanogaster) 		5 / 10 TYR A 256
VAL A 219
ASN A 218
ALA A 465
ASN A 228
 None
 1.32A 6gz9A-5wroA:
undetectable		 6gz9A-5wroA:
10.98