SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wrp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 345
GLU A 267
ALA A 265
HIS A 387
 None
 1.41A 1errA-5wrpA:
undetectable
1errB-5wrpA:
undetectable		 1errA-5wrpA:
20.42
1errB-5wrpA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 438
ALA A 369
GLU A 412
VAL A 429
 None
 0.70A 2bxgA-5wrpA:
undetectable		 2bxgA-5wrpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A 376
ALA A 384
ARG A 385
LEU A 392
 PO4  A 501 (-2.6A)
None
None
None
 1.01A 2bxkA-5wrpA:
undetectable		 2bxkA-5wrpA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A 376
ALA A 384
ARG A 385
LEU A 392
 PO4  A 501 (-2.6A)
None
None
None
 0.92A 2bxmA-5wrpA:
undetectable		 2bxmA-5wrpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 246
GLY A 243
VAL A 240
ASP A 126
LEU A 251
 None
 1.12A 3cjtG-5wrpA:
5.0		 3cjtG-5wrpA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 241
SER A 191
LEU A  65
VAL A  31
ILE A 216
 None
 1.18A 3claA-5wrpA:
undetectable		 3claA-5wrpA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 320
PRO A 319
LEU A  24
ARG A  50
 None
 1.43A 3hcoA-5wrpA:
2.3		 3hcoA-5wrpA:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		7 / 10 THR A  10
PRO A  13
ARG A  33
ASN A  35
HIS A  38
GLY A  39
GLY A 311
 None
 0.57A 3pp7B-5wrpA:
52.5		 3pp7B-5wrpA:
36.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 410
THR A 411
LEU A 405
ASP A 305
 None
 1.00A 3ps9A-5wrpA:
undetectable		 3ps9A-5wrpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 120
TYR A 109
LEU A 112
THR A 165
 None
 1.19A 4wozF-5wrpA:
7.7
4wozH-5wrpA:
13.3		 4wozF-5wrpA:
21.11
4wozH-5wrpA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 236
THR A 374
THR A 396
VAL A 401
 None
PO4  A 501 (-3.4A)
None
None
 1.13A 4yoaA-5wrpA:
undetectable		 4yoaA-5wrpA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		5 / 8 THR A 411
LEU A 392
THR A 374
THR A 379
LEU A 383
 None
None
PO4  A 501 (-3.4A)
PO4  A 501 (-3.8A)
None
 1.50A 4z90F-5wrpA:
undetectable
4z90G-5wrpA:
undetectable
4z90H-5wrpA:
undetectable
4z90I-5wrpA:
undetectable
4z90J-5wrpA:
undetectable		 4z90F-5wrpA:
20.79
4z90G-5wrpA:
20.79
4z90H-5wrpA:
20.79
4z90I-5wrpA:
20.79
4z90J-5wrpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 311
SER A 314
VAL A 315
HIS A  38
 None
 1.09A 5ewuA-5wrpA:
undetectable		 5ewuA-5wrpA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 275
SER A 281
THR A 289
GLU A 312
SER A 310
 None
 1.24A 5hfjE-5wrpA:
undetectable		 5hfjE-5wrpA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 223
ALA A 166
THR A 107
ARG A  74
LEU A 159
 None
 1.33A 5m54B-5wrpA:
undetectable		 5m54B-5wrpA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  86
GLY A 148
GLU A 147
LEU A 131
ASP A 125
 None
 1.40A 5vlmF-5wrpA:
undetectable		 5vlmF-5wrpA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5wrp PYRUVATE KINASE
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 115
ARG A 111
ARG A 194
GLU A 223
 None
 1.23A 6fbvD-5wrpA:
undetectable		 6fbvD-5wrpA:
18.06