SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wrr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		5 / 12 PHE A 435
LEU A 490
LEU A 481
ALA A 265
ILE A 505
 None
 1.13A 1crbA-5wrrA:
undetectable		 1crbA-5wrrA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		4 / 6 PHE A  96
TYR A 101
LEU A 466
VAL A 476
 None
 1.12A 1dz4B-5wrrA:
undetectable		 1dz4B-5wrrA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		4 / 5 PHE A 417
LEU A 117
PHE A 425
SER A 175
 None
 1.18A 1wrlC-5wrrA:
undetectable		 1wrlC-5wrrA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		5 / 12 LEU A 460
LEU A 463
LEU A 466
LEU A 405
LEU A 449
 None
 1.26A 1zucB-5wrrA:
undetectable		 1zucB-5wrrA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		5 / 12 ASP A 250
ILE A 255
ASP A 256
ARG A 259
ALA A 317
 None
 1.49A 2qmjA-5wrrA:
undetectable		 2qmjA-5wrrA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		4 / 6 PHE A  96
TYR A 101
LEU A 466
VAL A 476
 None
 1.19A 2zawA-5wrrA:
undetectable		 2zawA-5wrrA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		5 / 12 LEU A 226
GLY A 232
SER A 195
ARG A 136
ARG A 132
 None
 1.29A 3gyqA-5wrrA:
undetectable
3gyqB-5wrrA:
undetectable		 3gyqA-5wrrA:
21.99
3gyqB-5wrrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		4 / 7 SER A 195
VAL A 295
ARG A 284
PHE A 228
 None
 1.46A 3n5tA-5wrrA:
undetectable
3n5tB-5wrrA:
undetectable		 3n5tA-5wrrA:
21.83
3n5tB-5wrrA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		5 / 12 LEU A 486
GLU A 326
GLY A 338
SER A 339
LEU A 336
 None
 1.32A 3ou6D-5wrrA:
undetectable		 3ou6D-5wrrA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		5 / 12 TYR A 174
ASP A 270
PHE A 402
ASN A 431
ILE A 427
 None
 1.28A 3vwqA-5wrrA:
undetectable		 3vwqA-5wrrA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		4 / 6 PHE A  96
TYR A 101
LEU A 466
VAL A 476
 None
 1.11A 4kkyX-5wrrA:
undetectable		 4kkyX-5wrrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		4 / 7 PHE A  96
TYR A 101
LEU A 466
VAL A 476
 None
 1.06A 4l4gA-5wrrA:
undetectable		 4l4gA-5wrrA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8J_A_ADNA401_1
(RNA 3'-TERMINAL
PHOSPHATE CYCLASE)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		5 / 12 ARG A 352
LEU A 344
PRO A 279
PRO A 280
ASP A 430
 None
 1.46A 4o8jA-5wrrA:
0.2		 4o8jA-5wrrA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8J_B_ADNB401_1
(RNA 3'-TERMINAL
PHOSPHATE CYCLASE)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		5 / 12 ARG A 352
LEU A 344
PRO A 279
PRO A 280
ASP A 430
 None
 1.45A 4o8jB-5wrrA:
0.3		 4o8jB-5wrrA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		3 / 3 ASP A 524
LYS A 458
LEU A 100
 None
 0.95A 4ptjA-5wrrA:
undetectable		 4ptjA-5wrrA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		5 / 11 PHE A 275
GLY A 407
PHE A 435
ALA A 266
ASP A 270
 None
 1.21A 4wnuC-5wrrA:
undetectable		 4wnuC-5wrrA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		5 / 12 LEU A 340
PHE A 236
THR A 193
ALA A 196
LEU A 301
 None
 1.06A 5iepA-5wrrA:
undetectable		 5iepA-5wrrA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		4 / 7 PHE A 228
SER A 195
VAL A 295
ARG A 284
 None
 1.44A 5vv7A-5wrrA:
undetectable
5vv7B-5wrrA:
undetectable		 5vv7A-5wrrA:
21.62
5vv7B-5wrrA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		4 / 7 PHE A  96
TYR A 101
LEU A 466
VAL A 476
 None
 1.04A 5wk9A-5wrrA:
undetectable		 5wk9A-5wrrA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		4 / 6 ARG A 227
GLY A 232
SER A 195
THR A 193
 None
 1.24A 5ysiA-5wrrA:
undetectable		 5ysiA-5wrrA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		3 / 3 ARG A 227
ILE A 194
SER A 195
 None
 0.86A 5zw2A-5wrrA:
undetectable		 5zw2A-5wrrA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		4 / 7 SER A 195
VAL A 295
ARG A 284
PHE A 228
 None
 1.46A 6av6A-5wrrA:
undetectable
6av6B-5wrrA:
undetectable		 6av6A-5wrrA:
10.60
6av6B-5wrrA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		4 / 7 PHE A 228
SER A 195
VAL A 295
ARG A 284
 None
 1.37A 6av6C-5wrrA:
undetectable
6av6D-5wrrA:
undetectable		 6av6C-5wrrA:
10.60
6av6D-5wrrA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5wrr PSEUDOKINASE FAM20A
(Homo
sapiens) 		4 / 6 LEU A 353
THR A 418
GLY A 421
ARG A 392
 None
 1.38A 6gtqB-5wrrA:
undetectable
6gtqD-5wrrA:
undetectable		 6gtqB-5wrrA:
15.83
6gtqD-5wrrA:
7.31