SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wrt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE
(Toxoplasma
gondii) 		5 / 11 VAL A 210
PRO A 211
TYR A 158
ILE A 126
ILE A 145
 None
 1.43A 3ganA-5wrtA:
undetectable		 3ganA-5wrtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE
(Toxoplasma
gondii) 		4 / 5 VAL A 294
ILE A 199
MET A 122
ILE A 233
 None
 0.85A 4c8bA-5wrtA:
undetectable		 4c8bA-5wrtA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE
(Toxoplasma
gondii) 		5 / 12 GLU A 183
GLU A 178
HIS A 300
TRP A 173
GLY A 189
 None
 1.38A 4olfA-5wrtA:
undetectable		 4olfA-5wrtA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE
(Toxoplasma
gondii) 		5 / 12 GLY A 236
PRO A 238
MET A 122
GLU A 202
LEU A 204
 None
 1.28A 4x61A-5wrtA:
undetectable		 4x61A-5wrtA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE
(Toxoplasma
gondii) 		5 / 12 GLY A 236
PRO A 238
MET A 122
GLU A 202
LEU A 204
 None
 1.26A 5emlA-5wrtA:
undetectable		 5emlA-5wrtA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE
(Toxoplasma
gondii) 		4 / 6 PHE A 278
ARG A 261
GLU A 250
VAL A 246
 None
 1.28A 5h4dA-5wrtA:
undetectable		 5h4dA-5wrtA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE
(Toxoplasma
gondii) 		5 / 12 ARG A 261
LEU A 218
VAL A 197
VAL A 249
GLY A 255
 None
 1.44A 5i8fA-5wrtA:
undetectable		 5i8fA-5wrtA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE
(Toxoplasma
gondii) 		4 / 7 GLU A 125
THR A 143
PRO A 102
PRO A 193
 MG  A 402 ( 4.3A)
None
None
None
 1.50A 6a4iB-5wrtA:
undetectable		 6a4iB-5wrtA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE
(Toxoplasma
gondii) 		5 / 10 VAL A 249
LEU A 252
GLY A 200
GLY A 259
VAL A 257
 None
 1.16A 6eu9B-5wrtA:
undetectable		 6eu9B-5wrtA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE
(Toxoplasma
gondii) 		5 / 12 GLU A 183
GLU A 178
HIS A 300
TRP A 173
GLY A 189
 None
 1.39A 6mn8A-5wrtA:
undetectable		 6mn8A-5wrtA:
18.01