SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 5wru PROBABLE INORGANIC
PYROPHOSPHATASE
(Plasmodium
falciparum) 		5 / 12 ALA A 170
GLY A 169
GLU A 138
ASP A 198
ASP A 235
 None
 1.31A 1a4lD-5wruA:
undetectable		 1a4lD-5wruA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5wru PROBABLE INORGANIC
PYROPHOSPHATASE
(Plasmodium
falciparum) 		4 / 8 VAL A 217
PRO A 172
SER A 109
GLU A  99
 None
 1.18A 1jtvA-5wruA:
undetectable		 1jtvA-5wruA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5wru PROBABLE INORGANIC
PYROPHOSPHATASE
(Plasmodium
falciparum) 		3 / 3 LYS A 282
ASP A 235
ASP A 200
 None
 1.12A 2br4A-5wruA:
undetectable		 2br4A-5wruA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5wru PROBABLE INORGANIC
PYROPHOSPHATASE
(Plasmodium
falciparum) 		5 / 12 GLY A 224
SER A 296
ASP A 206
ILE A 207
LEU A 223
 None
 1.32A 3iv6D-5wruA:
undetectable		 3iv6D-5wruA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5wru PROBABLE INORGANIC
PYROPHOSPHATASE
(Plasmodium
falciparum) 		4 / 4 LEU A 212
ILE A 148
TYR A 168
TYR A  66
 None
 1.40A 3vt7A-5wruA:
undetectable		 3vt7A-5wruA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 5wru PROBABLE INORGANIC
PYROPHOSPHATASE
(Plasmodium
falciparum) 		4 / 5 LEU A 269
ARG A 273
ILE A 229
ASN A 361
 None
 1.37A 4i00A-5wruA:
undetectable		 4i00A-5wruA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA501_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 5wru PROBABLE INORGANIC
PYROPHOSPHATASE
(Plasmodium
falciparum) 		4 / 5 LEU A 116
LYS A 117
ASP A 115
HIS A 304
 None
 1.24A 4i90A-5wruA:
0.0		 4i90A-5wruA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 5wru PROBABLE INORGANIC
PYROPHOSPHATASE
(Plasmodium
falciparum) 		4 / 8 SER A 109
HIS A 112
ILE A 139
TRP A 111
 None
 1.33A 4ms4A-5wruA:
undetectable		 4ms4A-5wruA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 5wru PROBABLE INORGANIC
PYROPHOSPHATASE
(Plasmodium
falciparum) 		4 / 8 TYR A  97
ILE A 148
ILE A 139
ALA A 170
 None
 0.95A 4ou1A-5wruA:
undetectable		 4ou1A-5wruA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 5wru PROBABLE INORGANIC
PYROPHOSPHATASE
(Plasmodium
falciparum) 		3 / 3 ILE A  65
MET A  81
ASP A  67
 None
 0.82A 5h2uA-5wruA:
undetectable		 5h2uA-5wruA:
18.07