SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wsg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5wsg PRE-MRNA-SPLICING
FACTOR
CEF1,PRE-MRNA-SPLICI
NG FACTOR
CEF1,CEF1,PRE-MRNA-S
PLICING FACTOR CEF1
(Saccharomyces
cerevisiae) 		4 / 7 GLN c  96
ALA c  88
PHE c  62
GLU c  54
 None
 1.36A 1t9wA-5wsgc:
undetectable		 1t9wA-5wsgc:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 4 MET d 122
ALA d 118
TYR d 105
ILE d 106
 None
 1.41A 1upfD-5wsgd:
undetectable		 1upfD-5wsgd:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 7 VAL d 206
VAL d 193
TRP d 205
TRP d 202
 None
 1.23A 1zzrA-5wsgd:
undetectable
1zzrB-5wsgd:
undetectable		 1zzrA-5wsgd:
12.50
1zzrB-5wsgd:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 7 TRP d 202
VAL d 206
VAL d 193
TRP d 205
 None
 1.24A 1zzrA-5wsgd:
undetectable
1zzrB-5wsgd:
undetectable		 1zzrA-5wsgd:
12.50
1zzrB-5wsgd:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 7 VAL d 206
VAL d 193
TRP d 205
TRP d 202
 None
 1.26A 1zzuA-5wsgd:
undetectable
1zzuB-5wsgd:
2.4		 1zzuA-5wsgd:
12.50
1zzuB-5wsgd:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 7 TRP d 202
VAL d 206
VAL d 193
TRP d 205
 None
 1.26A 1zzuA-5wsgd:
undetectable
1zzuB-5wsgd:
2.4		 1zzuA-5wsgd:
12.50
1zzuB-5wsgd:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 6 SER d 220
PHE d 217
ARG d 186
GLU d 216
 None
 1.43A 2c8aC-5wsgd:
undetectable		 2c8aC-5wsgd:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 5wsg PRE-MRNA-SPLICING
FACTOR
CEF1,PRE-MRNA-SPLICI
NG FACTOR
CEF1,CEF1,PRE-MRNA-S
PLICING FACTOR CEF1
(Saccharomyces
cerevisiae) 		4 / 5 GLN c 163
ALA c 167
ILE c 171
ARG c 174
 None
C  E  85 ( 3.3A)
None
G  E  86 ( 4.0A)
 1.06A 2z0aA-5wsgc:
undetectable		 2z0aA-5wsgc:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 7 VAL d 206
VAL d 193
TRP d 205
TRP d 202
 None
 1.21A 3dqrA-5wsgd:
undetectable
3dqrB-5wsgd:
undetectable		 3dqrA-5wsgd:
12.44
3dqrB-5wsgd:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 6 VAL d 206
VAL d 193
TRP d 205
TRP d 202
 None
 1.20A 3n61A-5wsgd:
undetectable
3n61B-5wsgd:
undetectable		 3n61A-5wsgd:
12.44
3n61B-5wsgd:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 7 TRP d 202
VAL d 206
VAL d 193
TRP d 205
 None
 1.22A 3nlqA-5wsgd:
undetectable
3nlqB-5wsgd:
undetectable		 3nlqA-5wsgd:
12.44
3nlqB-5wsgd:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 5wsg PRE-MRNA-SPLICING
FACTOR
CEF1,PRE-MRNA-SPLICI
NG FACTOR
CEF1,CEF1,PRE-MRNA-S
PLICING FACTOR CEF1
(Saccharomyces
cerevisiae) 		4 / 7 LEU c 159
ARG c 158
GLY c  29
TYR c  28
 None
G  E  55 ( 3.2A)
None
G  E  55 ( 4.4A)
 0.98A 4cp3A-5wsgc:
undetectable
4cp3B-5wsgc:
undetectable		 4cp3A-5wsgc:
8.09
4cp3B-5wsgc:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 7 VAL d 206
VAL d 193
TRP d 205
TRP d 202
 None
 1.26A 4cx3A-5wsgd:
undetectable
4cx3B-5wsgd:
undetectable		 4cx3A-5wsgd:
12.44
4cx3B-5wsgd:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 7 TRP d 202
VAL d 206
VAL d 193
TRP d 205
 None
 1.24A 4cx3A-5wsgd:
undetectable
4cx3B-5wsgd:
undetectable		 4cx3A-5wsgd:
12.44
4cx3B-5wsgd:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 7 VAL d 206
VAL d 193
TRP d 205
TRP d 202
 None
 1.26A 4cx4A-5wsgd:
undetectable
4cx4B-5wsgd:
undetectable		 4cx4A-5wsgd:
12.44
4cx4B-5wsgd:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 7 TRP d 202
VAL d 206
VAL d 193
TRP d 205
 None
 1.25A 4cx4A-5wsgd:
undetectable
4cx4B-5wsgd:
undetectable		 4cx4A-5wsgd:
12.44
4cx4B-5wsgd:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5wsg PRE-MRNA-SPLICING
FACTOR
CEF1,PRE-MRNA-SPLICI
NG FACTOR
CEF1,CEF1,PRE-MRNA-S
PLICING FACTOR CEF1
PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		4 / 6 ASP d  80
GLU d  75
ASN c 214
ARG d  44
 None
 1.28A 4ntxA-5wsgd:
3.3
4ntxC-5wsgd:
undetectable		 4ntxA-5wsgd:
11.48
4ntxC-5wsgd:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5wsg PRE-MRNA-SPLICING
FACTOR
CEF1,PRE-MRNA-SPLICI
NG FACTOR
CEF1,CEF1,PRE-MRNA-S
PLICING FACTOR CEF1
(Saccharomyces
cerevisiae) 		3 / 3 LYS c 204
ASP c 210
ILE c 200
 U  N 107 ( 4.3A)
None
None
 0.89A 5kc4E-5wsgc:
undetectable		 5kc4E-5wsgc:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 5wsg PRE-MRNA-SPLICING
FACTOR
CLF1,PRE-MRNA-SPLICI
NG FACTOR CLF1,CLF1
(Saccharomyces
cerevisiae) 		3 / 3 LYS d 158
TRP d 159
SER d 161
 None
 0.62A 5nwwA-5wsgd:
undetectable		 5nwwA-5wsgd:
13.77