SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wsl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 11 GLY A  73
HIS A  72
HIS A  75
ILE A  37
GLY A 222
 None
 1.11A 1c9sP-5wslA:
undetectable
1c9sQ-5wslA:
undetectable		 1c9sP-5wslA:
12.21
1c9sQ-5wslA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 11 GLY A  73
HIS A  72
HIS A  75
ILE A  37
GLY A 222
 None
 1.07A 1gtfQ-5wslA:
undetectable
1gtfR-5wslA:
undetectable		 1gtfQ-5wslA:
12.21
1gtfR-5wslA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 11 GLY A  73
HIS A  72
HIS A  75
ILE A  37
GLY A 222
 None
 1.05A 1gtfS-5wslA:
undetectable
1gtfT-5wslA:
undetectable		 1gtfS-5wslA:
12.21
1gtfT-5wslA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 11 GLY A  73
HIS A  72
HIS A  75
ILE A  37
GLY A 222
 None
 1.05A 1gtnT-5wslA:
undetectable
1gtnU-5wslA:
undetectable		 1gtnT-5wslA:
12.21
1gtnU-5wslA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 12 GLY A 222
GLY A  73
HIS A  72
HIS A  75
ILE A  37
 None
 1.03A 1gtnL-5wslA:
undetectable
1gtnV-5wslA:
undetectable		 1gtnL-5wslA:
12.21
1gtnV-5wslA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		3 / 3 ALA A  55
VAL A  96
TRP A 116
 None
 0.94A 1jo4A-5wslA:
undetectable		 1jo4A-5wslA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		3 / 3 ALA A  55
VAL A  96
TRP A 116
 None
 0.94A 1jo4B-5wslA:
undetectable		 1jo4B-5wslA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		3 / 3 ALA A  55
VAL A  96
TRP A 116
 None
 0.87A 1magA-5wslA:
undetectable		 1magA-5wslA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		3 / 3 ALA A  55
VAL A  96
TRP A 116
 None
 0.87A 1magB-5wslA:
undetectable		 1magB-5wslA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 4 HIS A 229
ALA A 201
PHE A 200
GLY A 203
 None
 1.22A 1mj2B-5wslA:
undetectable		 1mj2B-5wslA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 4 HIS A 229
ALA A 201
PHE A 200
GLY A 203
 None
 1.24A 1mj2D-5wslA:
undetectable		 1mj2D-5wslA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 4 HIS A 229
ALA A 201
PHE A 200
GLY A 203
 None
 1.21A 1mjoB-5wslA:
undetectable		 1mjoB-5wslA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 4 HIS A 229
ALA A 201
PHE A 200
GLY A 203
 None
 1.16A 1mjoA-5wslA:
undetectable		 1mjoA-5wslA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 4 HIS A 229
ALA A 201
PHE A 200
GLY A 203
 None
 1.22A 1mjoD-5wslA:
undetectable		 1mjoD-5wslA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		3 / 3 ALA A  55
VAL A  96
TRP A 116
 None
 0.92A 1nrmA-5wslA:
undetectable		 1nrmA-5wslA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		3 / 3 ALA A  55
VAL A  96
TRP A 116
 None
 0.92A 1nrmB-5wslA:
undetectable		 1nrmB-5wslA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		3 / 3 ALA A  55
VAL A  96
TRP A 116
 None
 0.91A 1nruA-5wslA:
undetectable		 1nruA-5wslA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		3 / 3 ALA A  55
VAL A  96
TRP A 116
 None
 0.91A 1nruB-5wslA:
undetectable		 1nruB-5wslA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 10 THR A 177
PHE A 153
LEU A 139
VAL A 110
VAL A 143
 CA  A 302 (-3.5A)
None
None
None
None
 1.40A 1q23K-5wslA:
undetectable		 1q23K-5wslA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 12 PHE A 167
ALA A 180
LEU A 139
GLY A 222
LEU A 131
 None
 1.24A 1qabF-5wslA:
undetectable		 1qabF-5wslA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 7 THR A 152
ALA A 154
SER A 130
VAL A 126
 None
 0.67A 1tyrB-5wslA:
undetectable		 1tyrB-5wslA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 11 GLY A  73
HIS A  72
HIS A  75
ILE A  37
GLY A 222
 None
 1.06A 1utdS-5wslA:
undetectable
1utdT-5wslA:
undetectable		 1utdS-5wslA:
12.21
1utdT-5wslA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 11 THR A   7
GLU A  48
ALA A 209
ILE A 211
ASP A  68
 None
 1.34A 2admA-5wslA:
2.1		 2admA-5wslA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 11 THR A   7
GLU A  48
ALA A 209
ILE A 211
ASP A  68
 None
 1.27A 2admB-5wslA:
2.3		 2admB-5wslA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 6 LEU A 199
LEU A 197
ILE A 253
ARG A 250
 None
 1.02A 2rlfA-5wslA:
undetectable
2rlfB-5wslA:
undetectable		 2rlfA-5wslA:
8.33
2rlfB-5wslA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 12 PHE A  49
PRO A 228
ALA A 226
ALA A  53
ALA A  95
 None
 1.29A 2x2nA-5wslA:
undetectable		 2x2nA-5wslA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 12 ALA A 138
LEU A 139
VAL A 143
LEU A 131
ALA A 127
 SO4  A 304 (-3.3A)
None
None
None
None
 1.01A 3ozuA-5wslA:
2.0		 3ozuA-5wslA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 8 GLY A  30
THR A  29
ARG A  92
GLN A 239
 None
 0.66A 3rglA-5wslA:
undetectable		 3rglA-5wslA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		3 / 3 GLN A   3
PHE A  24
TYR A  26
 None
 0.76A 3ucjB-5wslA:
undetectable		 3ucjB-5wslA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 10 GLY A  86
ALA A 209
GLY A  78
VAL A  84
HIS A  46
 None
 1.49A 4c5lD-5wslA:
4.6		 4c5lD-5wslA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 8 LEU A 131
SER A 224
THR A  74
ASP A  68
 None
 1.04A 4drjB-5wslA:
undetectable		 4drjB-5wslA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 11 ILE A  42
ALA A  77
GLY A  78
GLU A  48
GLY A  30
 None
 1.00A 4e47A-5wslA:
undetectable		 4e47A-5wslA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 8 THR A 152
ALA A 154
SER A 130
VAL A 126
 None
 0.58A 4ik7B-5wslA:
undetectable		 4ik7B-5wslA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 11 ILE A  42
ALA A  77
GLY A  78
GLU A  48
GLY A  30
 None
 1.00A 4jdsA-5wslA:
undetectable		 4jdsA-5wslA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 11 ILE A  42
ALA A  77
GLY A  78
GLU A  48
GLY A  30
 None
 1.00A 4jdsB-5wslA:
undetectable		 4jdsB-5wslA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 7 GLN A  15
LEU A 273
THR A 258
THR A 227
 CA  A 301 ( 3.3A)
None
None
None
 0.99A 4mbsA-5wslA:
undetectable		 4mbsA-5wslA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 8 SER A 191
THR A 181
SER A 204
ASP A 185
 None
None
SO4  A 306 (-2.6A)
None
 1.34A 4qb9D-5wslA:
undetectable		 4qb9D-5wslA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 9 ALA A  53
ILE A  38
GLY A  41
SER A 208
VAL A  76
 None
 1.17A 4r20B-5wslA:
undetectable		 4r20B-5wslA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 10 THR A 177
ILE A 147
LEU A 139
MET A 129
PHE A 153
 CA  A 302 (-3.5A)
None
None
None
None
 1.24A 4r3aB-5wslA:
undetectable		 4r3aB-5wslA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 5 GLY A  82
THR A  83
GLY A  50
GLU A  48
 None
 0.91A 4v20A-5wslA:
undetectable		 4v20A-5wslA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 12 GLY A  78
TYR A  85
SER A  47
ALA A  53
ALA A  77
 None
 1.44A 4ymgA-5wslA:
undetectable		 4ymgA-5wslA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 12 GLY A  82
ILE A  60
GLY A 105
GLY A 103
THR A  79
 None
 0.99A 5eqbA-5wslA:
undetectable		 5eqbA-5wslA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 4 ALA A 209
PRO A 228
LEU A 131
HIS A  72
 None
 1.31A 5eskA-5wslA:
undetectable		 5eskA-5wslA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 10 ALA A  77
GLY A  51
PHE A  49
GLY A  81
VAL A  44
 None
 1.23A 5i6xA-5wslA:
undetectable		 5i6xA-5wslA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 12 VAL A  87
HIS A 229
SER A 276
GLY A  22
LEU A  20
 None
 1.19A 5m50B-5wslA:
undetectable		 5m50B-5wslA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 12 VAL A  87
HIS A 229
SER A 276
GLY A  22
LEU A  20
 None
 1.22A 5m50E-5wslA:
undetectable		 5m50E-5wslA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		4 / 5 PRO A 124
VAL A  33
GLY A 175
VAL A 249
 None
None
CA  A 302 (-4.0A)
None
 1.11A 6ak3B-5wslA:
undetectable		 6ak3B-5wslA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5wsl KERATINASE
(Meiothermus
taiwanensis) 		5 / 12 ALA A  95
LEU A  93
VAL A 233
HIS A 229
ALA A 209
 None
 0.92A 6djzC-5wslA:
undetectable		 6djzC-5wslA:
20.38