SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wt3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		5 / 12 TYR A 282
ALA A 192
TYR A 197
GLY A 193
ARG A 174
 None
None
None
MTA  A 401 (-3.6A)
None
 1.33A 1vpoH-5wt3A:
undetectable
1vpoL-5wt3A:
undetectable		 1vpoH-5wt3A:
15.38
1vpoL-5wt3A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		6 / 11 PRO A 196
GLU A 213
ILE A 214
ALA A 218
ASP A 243
PRO A 262
 None
MTA  A 401 (-3.5A)
MTA  A 401 (-3.7A)
None
MTA  A 401 (-3.3A)
G  C  37 ( 4.1A)
 0.74A 2admA-5wt3A:
12.1		 2admA-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		6 / 11 PRO A 196
GLU A 213
ILE A 214
ALA A 218
ASP A 243
PRO A 262
 None
MTA  A 401 (-3.5A)
MTA  A 401 (-3.7A)
None
MTA  A 401 (-3.3A)
G  C  37 ( 4.1A)
 0.77A 2admB-5wt3A:
11.8		 2admB-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		8 / 12 ARG A 133
PHE A 191
GLY A 193
PRO A 196
ILE A 214
ASN A 215
ASP A 243
VAL A 244
 G  C  37 ( 4.0A)
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.7A)
None
MTA  A 401 (-3.3A)
MTA  A 401 (-3.8A)
 0.63A 2zzmA-5wt3A:
28.0		 2zzmA-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		9 / 12 ARG A 133
ARG A 174
PHE A 191
GLY A 193
PRO A 196
ILE A 214
ASN A 215
ASP A 243
VAL A 244
 G  C  37 ( 4.0A)
None
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.7A)
None
MTA  A 401 (-3.3A)
MTA  A 401 (-3.8A)
 0.66A 2zznA-5wt3A:
28.1		 2zznA-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		8 / 12 PHE A 166
ARG A 174
PHE A 191
GLY A 193
PRO A 196
ILE A 214
ASN A 215
ASP A 243
 None
None
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.7A)
None
MTA  A 401 (-3.3A)
 0.66A 2zznB-5wt3A:
28.2		 2zznB-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		5 / 12 ARG A 174
PHE A 191
GLY A 193
ASN A 215
ASP A 243
 None
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.3A)
 0.81A 3a27A-5wt3A:
23.7		 3a27A-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		3 / 3 PRO A 196
LEU A 199
ARG A 232
 None
 0.69A 3aqiB-5wt3A:
undetectable		 3aqiB-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		6 / 10 PHE A 191
ILE A 214
ASN A 215
ALA A 218
ASP A 243
VAL A 244
 MTA  A 401 (-4.4A)
MTA  A 401 (-3.7A)
None
None
MTA  A 401 (-3.3A)
MTA  A 401 (-3.8A)
 0.65A 3ay0A-5wt3A:
25.6		 3ay0A-5wt3A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		6 / 10 PHE A 191
GLY A 193
ILE A 214
ASN A 215
ASP A 243
VAL A 244
 MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
MTA  A 401 (-3.7A)
None
MTA  A 401 (-3.3A)
MTA  A 401 (-3.8A)
 0.59A 3ay0B-5wt3A:
23.4		 3ay0B-5wt3A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		3 / 3 MET A 170
CYH A 326
PRO A 260
 G  C  37 ( 4.4A)
None
None
 1.24A 3h52C-5wt3A:
undetectable		 3h52C-5wt3A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		3 / 3 SER A 316
MET A 170
ASP A 328
 None
G  C  37 ( 4.4A)
None
 0.89A 4mm4B-5wt3A:
undetectable		 4mm4B-5wt3A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		5 / 12 PHE A 191
GLY A 193
ILE A 214
ASN A 215
PRO A 262
 MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
MTA  A 401 (-3.7A)
None
G  C  37 ( 4.1A)
 0.83A 4rtmA-5wt3A:
0.0		 4rtmA-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		5 / 12 PHE A 191
GLY A 193
ILE A 214
ASN A 215
PRO A 262
 MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
MTA  A 401 (-3.7A)
None
G  C  37 ( 4.1A)
 0.79A 4rtpA-5wt3A:
11.2		 4rtpA-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		5 / 12 PHE A 191
GLY A 193
ILE A 214
ASN A 215
PRO A 262
 MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
MTA  A 401 (-3.7A)
None
G  C  37 ( 4.1A)
 0.82A 4rtsA-5wt3A:
10.6		 4rtsA-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		5 / 12 ASP A 243
PRO A 262
PHE A 191
GLY A 193
GLU A 213
 MTA  A 401 (-3.3A)
G  C  37 ( 4.1A)
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
 0.63A 5hfjA-5wt3A:
2.9		 5hfjA-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		5 / 12 ASP A 243
PRO A 262
PHE A 191
GLY A 193
GLU A 213
 MTA  A 401 (-3.3A)
G  C  37 ( 4.1A)
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
 0.65A 5hfjD-5wt3A:
2.6		 5hfjD-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		5 / 12 ASP A 243
PRO A 262
PHE A 191
GLY A 193
GLU A 213
 MTA  A 401 (-3.3A)
G  C  37 ( 4.1A)
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
 0.73A 5hfjF-5wt3A:
2.3		 5hfjF-5wt3A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		11 / 11 LEU A 131
TYR A 132
ARG A 133
PHE A 191
GLY A 193
GLU A 213
ILE A 214
ASN A 215
ASP A 243
VAL A 244
PRO A 262
 None
None
G  C  37 ( 4.0A)
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
MTA  A 401 (-3.7A)
None
MTA  A 401 (-3.3A)
MTA  A 401 (-3.8A)
G  C  37 ( 4.1A)
 0.65A 5hjiA-5wt3A:
38.4		 5hjiA-5wt3A:
80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		3 / 3 ALA A 222
ASN A 225
LEU A 226
 None
 0.40A 5i1nB-5wt3A:
undetectable		 5i1nB-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A
(Pyrococcus
abyssi) 		4 / 7 LEU A 228
VAL A 155
GLU A 152
ILE A 239
 None
 1.07A 5jh7C-5wt3A:
undetectable		 5jh7C-5wt3A:
undetectable