SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wt4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 5 GLU A  43
THR A  44
HIS A  45
HIS A  38
 None
 1.37A 1d4fA-5wt4A:
2.3		 1d4fA-5wt4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 5 GLU A  43
THR A  44
HIS A  45
HIS A  38
 None
 1.42A 1d4fD-5wt4A:
2.3		 1d4fD-5wt4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 4 ARG A 138
ALA A 134
ALA A 168
GLU A 172
 None
 1.18A 1e7bB-5wt4A:
undetectable		 1e7bB-5wt4A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 5 ARG A 138
ALA A 134
ALA A 168
GLU A 172
 None
 1.23A 1e7cA-5wt4A:
undetectable		 1e7cA-5wt4A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 TYR A 246
ALA A 253
GLY A 249
ALA A 257
ILE A  15
 None
 1.05A 1ve3A-5wt4A:
undetectable		 1ve3A-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 PHE A 228
ALA A 204
SER A 203
ALA A  73
GLY A 209
 None
None
C6P  A 502 (-2.4A)
C6P  A 502 (-3.8A)
None
 1.12A 2igtA-5wt4A:
3.5		 2igtA-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 PHE A 228
ALA A 204
SER A 203
ALA A  73
GLY A 209
 None
None
C6P  A 502 (-2.4A)
C6P  A 502 (-3.8A)
None
 1.12A 2igtB-5wt4A:
3.3		 2igtB-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 PHE A 228
ALA A 204
SER A 203
ALA A  73
GLY A 209
 None
None
C6P  A 502 (-2.4A)
C6P  A 502 (-3.8A)
None
 1.14A 2igtC-5wt4A:
3.6		 2igtC-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 ILE A 185
PHE A 202
ALA A 181
THR A 179
ALA A 195
 None
 1.06A 2j0dA-5wt4A:
undetectable		 2j0dA-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 5 ALA A 322
ALA A 376
ALA A 377
VAL A 303
 None
 0.90A 2nyrB-5wt4A:
2.1		 2nyrB-5wt4A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		3 / 3 LEU A 224
VAL A  67
ARG A 237
 None
 0.84A 3b0wB-5wt4A:
undetectable		 3b0wB-5wt4A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 5 TYR A 263
PRO A 296
THR A 298
THR A 362
 None
 1.47A 3q07A-5wt4A:
undetectable		 3q07A-5wt4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 5 TYR A 263
PRO A 296
THR A 298
THR A 362
 None
 1.47A 3q07B-5wt4A:
undetectable		 3q07B-5wt4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 8 ASN A   9
LEU A   7
ASN A 361
ILE A 366
 None
 1.00A 4k0bA-5wt4A:
undetectable		 4k0bA-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 8 ASN A   9
LEU A   7
ASN A 361
ILE A 366
 None
 1.06A 4l7iA-5wt4A:
undetectable		 4l7iA-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 6 GLU A  43
THR A  42
GLN A  39
THR A 241
 None
 1.19A 4pfjB-5wt4A:
2.5		 4pfjB-5wt4A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 7 PHE A 207
ILE A 185
GLY A 214
THR A  70
 None
 0.91A 4zdzA-5wt4A:
undetectable		 4zdzA-5wt4A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 11 VAL A 244
PHE A 207
GLY A 214
GLY A 215
ILE A  68
 None
 1.32A 4zvmA-5wt4A:
undetectable
4zvmB-5wt4A:
2.4		 4zvmA-5wt4A:
16.74
4zvmB-5wt4A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 5 VAL A  84
VAL A 222
GLY A 223
PHE A 199
 None
 1.09A 5d4nA-5wt4A:
undetectable
5d4nC-5wt4A:
undetectable		 5d4nA-5wt4A:
undetectable
5d4nC-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 8 ALA A  11
HIS A 104
ASN A 155
LYS A 206
ARG A 354
 C6P  A 502 ( 4.1A)
C6P  A 502 (-3.4A)
C6P  A 502 (-3.8A)
C6P  A 502 (-2.9A)
C6P  A 502 (-3.8A)
 0.77A 5db5A-5wt4A:
40.0
5db5B-5wt4A:
40.1		 5db5A-5wt4A:
undetectable
5db5B-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 VAL A 107
LEU A 216
SER A 149
LEU A 224
THR A 225
 None
 1.09A 5hnwB-5wt4A:
2.9		 5hnwB-5wt4A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 VAL A 107
LEU A 216
SER A 149
LEU A 224
THR A 225
 None
 1.11A 5hnxB-5wt4A:
undetectable		 5hnxB-5wt4A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 VAL A 107
LEU A 216
SER A 149
LEU A 224
THR A 225
 None
 1.09A 5hnyB-5wt4A:
undetectable		 5hnyB-5wt4A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 GLU A 266
ASP A 262
ASP A 273
GLN A 183
GLY A 186
 None
None
None
C6P  A 502 (-3.8A)
None
 1.31A 5syeB-5wt4A:
undetectable		 5syeB-5wt4A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 5 VAL A  80
LEU A 114
CYH A 111
ASP A 180
 None
None
None
C6P  A 502 (-2.9A)
 1.41A 5vcvA-5wt4A:
undetectable		 5vcvA-5wt4A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 MET A 254
ALA A 204
LEU A  55
ILE A  59
ASP A  66
 None
None
None
None
IPA  A 501 ( 4.7A)
 1.28A 5vlmG-5wt4A:
undetectable		 5vlmG-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 8 GLU A 103
HIS A 178
PHE A 202
LEU A  55
 None
 1.08A 5y2tB-5wt4A:
undetectable		 5y2tB-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 9 VAL A 258
GLY A 249
VAL A  19
GLU A 252
PRO A 210
 None
 1.29A 5zniA-5wt4A:
undetectable		 5zniA-5wt4A:
17.28