SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wt7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5wt7 PERIOSTIN
(Homo
sapiens) 		5 / 12 VAL A 112
GLN A  97
ILE A 101
SER A  99
PHE A  42
 None
 1.41A 2vdyA-5wt7A:
undetectable		 2vdyA-5wt7A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wt7 PERIOSTIN
(Homo
sapiens) 		4 / 4 ILE A  61
GLN A  68
ILE A  59
LEU A  29
 None
 1.24A 3dzyD-5wt7A:
undetectable		 3dzyD-5wt7A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5wt7 PERIOSTIN
(Homo
sapiens) 		5 / 11 LEU A  21
LEU A  24
GLU A   9
LEU A  11
LEU A  33
 None
 1.11A 4wg0H-5wt7A:
undetectable
4wg0I-5wt7A:
undetectable
4wg0J-5wt7A:
undetectable		 4wg0H-5wt7A:
undetectable
4wg0I-5wt7A:
undetectable
4wg0J-5wt7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5wt7 PERIOSTIN
(Homo
sapiens) 		5 / 11 LEU A  33
GLU A   9
LEU A  11
LEU A  21
LEU A  24
 None
 1.11A 4wg0K-5wt7A:
undetectable
4wg0L-5wt7A:
undetectable
4wg0M-5wt7A:
undetectable		 4wg0K-5wt7A:
undetectable
4wg0L-5wt7A:
undetectable
4wg0M-5wt7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5wt7 PERIOSTIN
(Homo
sapiens) 		5 / 12 LEU A   7
VAL A 131
TYR A  73
PHE A  17
LEU A  11
 None
 1.38A 5cymA-5wt7A:
undetectable		 5cymA-5wt7A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5wt7 PERIOSTIN
(Homo
sapiens) 		5 / 12 LEU A   7
VAL A 131
TYR A  73
PHE A  17
LEU A  11
 None
 1.42A 5cyqA-5wt7A:
undetectable		 5cyqA-5wt7A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 5wt7 PERIOSTIN
(Homo
sapiens) 		5 / 12 LEU A   7
VAL A 131
TYR A  73
PHE A  17
LEU A  11
 None
 1.42A 6eliA-5wt7A:
undetectable		 6eliA-5wt7A:
26.74