SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wtf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 5wtf VP0
VP1
(Hepatovirus
A) 		3 / 3 TRP B 180
TYR B 165
LEU A 136
 None
 1.03A 1kxhA-5wtfB:
undetectable		 1kxhA-5wtfB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5wtf VP0
(Hepatovirus
A) 		4 / 7 VAL B 204
VAL B  78
ALA B  66
LEU B 202
 None
 0.87A 1pthA-5wtfB:
undetectable		 1pthA-5wtfB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5wtf VP0
(Hepatovirus
A) 		4 / 7 VAL B 204
VAL B  78
ALA B  66
LEU B 202
 None
 0.87A 1pthB-5wtfB:
undetectable		 1pthB-5wtfB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 5wtf VP1
(Hepatovirus
A) 		5 / 9 THR A 252
PRO A 140
GLY A 139
SER A 255
LEU A 249
 None
 1.48A 1urmA-5wtfA:
undetectable		 1urmA-5wtfA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5wtf VP1
(Hepatovirus
A) 		5 / 12 ILE A 200
LEU A 143
PHE A 109
PHE A  98
PHE A 245
 None
 1.13A 2ygpA-5wtfA:
undetectable		 2ygpA-5wtfA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5wtf VP0
VP1
(Hepatovirus
A) 		3 / 3 THR A  53
GLU A  56
HIS B 146
 None
 0.82A 3g1uB-5wtfA:
undetectable		 3g1uB-5wtfA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5wtf VP1
(Hepatovirus
A) 		4 / 7 LEU A 123
LEU A  95
SER A 250
THR A 144
 None
 0.98A 3lm8A-5wtfA:
3.7
3lm8C-5wtfA:
3.5		 3lm8A-5wtfA:
20.48
3lm8C-5wtfA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 5wtf VP0
VP1
(Hepatovirus
A) 		5 / 10 GLY A 213
ALA A 214
ASP B 132
VAL B 129
GLY B 136
 None
 0.99A 4dqbB-5wtfA:
undetectable		 4dqbB-5wtfA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 5wtf VP0
VP1
(Hepatovirus
A) 		5 / 9 GLY A 213
ALA A 214
ASP B 132
VAL B 129
GLY B 136
 None
 1.05A 4dqcB-5wtfA:
undetectable		 4dqcB-5wtfA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 5wtf VP0
VP1
(Hepatovirus
A) 		5 / 10 GLY A 213
ALA A 214
ASP B 132
VAL B 129
GLY B 136
 None
 0.98A 4dqeB-5wtfA:
undetectable		 4dqeB-5wtfA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 5wtf VP0
VP1
(Hepatovirus
A) 		5 / 10 GLY A 213
ALA A 214
ASP B 132
VAL B 129
GLY B 136
 None
 0.99A 4dqhB-5wtfA:
undetectable		 4dqhB-5wtfA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5wtf VP1
(Hepatovirus
A) 		4 / 8 ASN A 265
ALA A 268
SER A 266
ARG A 128
 None
 1.07A 4ijiF-5wtfA:
undetectable		 4ijiF-5wtfA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5wtf VP1
(Hepatovirus
A) 		4 / 7 ASN A 265
ALA A 268
SER A 266
ARG A 128
 None
 1.07A 4ijiH-5wtfA:
undetectable		 4ijiH-5wtfA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_B_ACTB202_0
(RETINOL-BINDING
PROTEIN 2)		 5wtf VP1
VP0
(Hepatovirus
A;
Hepatovirus
A) 		4 / 7 TYR B 177
LEU A 215
GLN A 135
ARG A 261
 None
 1.43A 4qzuB-5wtfB:
undetectable		 4qzuB-5wtfB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wtf VP1
(Hepatovirus
A) 		4 / 6 ASP A  57
ALA A  61
THR A  54
THR A  53
 None
 1.33A 4w5qA-5wtfA:
undetectable		 4w5qA-5wtfA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wtf VP1
(Hepatovirus
A) 		4 / 6 ASP A  57
ALA A  61
THR A  54
THR A  53
 None
 1.33A 4w5rA-5wtfA:
undetectable		 4w5rA-5wtfA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wtf VP1
(Hepatovirus
A) 		4 / 6 ASP A  57
ALA A  61
THR A  54
THR A  53
 None
 1.37A 4w5tA-5wtfA:
undetectable		 4w5tA-5wtfA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5wtf VP1
(Hepatovirus
A) 		4 / 6 ASP A  57
ALA A  61
THR A  54
THR A  53
 None
 1.35A 4z4cA-5wtfA:
undetectable		 4z4cA-5wtfA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wtf VP1
(Hepatovirus
A) 		4 / 6 ASP A  57
ALA A  61
THR A  54
THR A  53
 None
 1.31A 4z4fA-5wtfA:
undetectable		 4z4fA-5wtfA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5wtf VP1
(Hepatovirus
A) 		4 / 5 ASP A  57
ALA A  61
THR A  54
THR A  53
 None
 1.33A 4z4gA-5wtfA:
undetectable		 4z4gA-5wtfA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wtf VP1
(Hepatovirus
A) 		4 / 6 ASP A  57
ALA A  61
THR A  54
THR A  53
 None
 1.35A 4z4iA-5wtfA:
undetectable		 4z4iA-5wtfA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5wtf VP1
(Hepatovirus
A) 		5 / 11 VAL A 153
PHE A 190
ILE A 145
ILE A 231
LEU A 243
 None
 1.01A 5e4dB-5wtfA:
undetectable		 5e4dB-5wtfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5wtf VP1
(Hepatovirus
A) 		3 / 3 PRO A 119
LEU A 264
SER A 271
 None
 0.62A 5fsaB-5wtfA:
undetectable		 5fsaB-5wtfA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 5wtf VP0
VP1
(Hepatovirus
A) 		5 / 9 GLY A 213
ALA A 214
ASP B 132
VAL B 129
GLY B 136
 None
 0.97A 5kr0B-5wtfA:
undetectable		 5kr0B-5wtfA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5wtf VP1
(Hepatovirus
A) 		5 / 12 SER A 255
LEU A  95
PHE A 131
PHE A 130
LEU A 123
 None
 1.38A 6a93A-5wtfA:
undetectable		 6a93A-5wtfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5wtf VP1
(Hepatovirus
A) 		5 / 12 SER A 255
LEU A  95
PHE A 131
PHE A 130
LEU A 123
 None
 1.32A 6a93B-5wtfA:
undetectable		 6a93B-5wtfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5wtf VP0
(Hepatovirus
A) 		4 / 6 LEU B 141
TYR B 144
VAL B  84
GLY B 136
 None
 0.85A 6hd4B-5wtfB:
undetectable		 6hd4B-5wtfB:
15.92