SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5wth POLYPROTEIN
(Hepatovirus
A) 		4 / 5 PHE A 134
LEU A 113
MET A  89
SER A  92
 None
 1.26A 1wrlC-5wthA:
undetectable		 1wrlC-5wthA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5wth POLYPROTEIN
(Hepatovirus
A) 		4 / 7 LEU A 123
LEU A  95
SER A 250
THR A 144
 None
 1.05A 3lm8A-5wthA:
2.5
3lm8C-5wthA:
2.4		 3lm8A-5wthA:
21.89
3lm8C-5wthA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5wth POLYPROTEIN
(Hepatovirus
A) 		3 / 3 ASP A 180
THR A 160
PRO A 161
 None
 0.61A 3tkgD-5wthA:
undetectable		 3tkgD-5wthA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_C_CLMC221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wth POLYPROTEIN
(Hepatovirus
A) 		5 / 11 THR A 252
SER A 255
TYR A 137
VAL A 229
PHE A 159
 None
 1.48A 3u9fA-5wthA:
undetectable
3u9fC-5wthA:
undetectable		 3u9fA-5wthA:
21.55
3u9fC-5wthA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5wth POLYPROTEIN
(Hepatovirus
A) 		5 / 11 VAL A 153
PHE A 190
ILE A 145
ILE A 231
LEU A 243
 None
 1.08A 5e4dB-5wthA:
undetectable		 5e4dB-5wthA:
21.31