SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wti'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		3 / 3 PHE Z 120
LEU Z 175
SER Z 131
 None
 0.88A 1e7aA-5wtiZ:
undetectable		 1e7aA-5wtiZ:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 4 TRP Z 850
ARG Z 791
ASP Z 574
ASN Z 954
 None
None
MG  Z1202 (-2.3A)
None
 1.46A 1kiaA-5wtiZ:
0.3		 1kiaA-5wtiZ:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 6 TRP Z 850
ARG Z 791
ASP Z 574
ASN Z 954
 None
None
MG  Z1202 (-2.3A)
None
 1.45A 1kiaC-5wtiZ:
undetectable		 1kiaC-5wtiZ:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 5 TRP Z 850
ARG Z 791
ASP Z 574
ASN Z 954
 None
None
MG  Z1202 (-2.3A)
None
 1.46A 1kiaD-5wtiZ:
undetectable		 1kiaD-5wtiZ:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQP_A_FCNA4002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		5 / 10 HIS Z  49
GLU Z  51
ARG Z 490
HIS Z 385
THR Z 378
 A  B 108 ( 4.9A)
None
G  B 107 ( 2.9A)
G  B 107 ( 3.7A)
A  B 108 ( 3.2A)
 1.45A 1lqpA-5wtiZ:
0.0
1lqpB-5wtiZ:
0.0		 1lqpA-5wtiZ:
7.27
1lqpB-5wtiZ:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQP_B_FCNB4001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		5 / 10 HIS Z 385
THR Z 378
HIS Z  49
GLU Z  51
ARG Z 490
 G  B 107 ( 3.7A)
A  B 108 ( 3.2A)
A  B 108 ( 4.9A)
None
G  B 107 ( 2.9A)
 1.46A 1lqpA-5wtiZ:
0.0
1lqpB-5wtiZ:
0.0		 1lqpA-5wtiZ:
7.27
1lqpB-5wtiZ:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 5 TRP Z 850
ARG Z 791
ASP Z 574
ASN Z 954
 None
None
MG  Z1202 (-2.3A)
None
 1.47A 1nbhB-5wtiZ:
1.8		 1nbhB-5wtiZ:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 4 TRP Z 850
ARG Z 791
ASP Z 574
ASN Z 954
 None
None
MG  Z1202 (-2.3A)
None
 1.49A 1nbhC-5wtiZ:
1.8		 1nbhC-5wtiZ:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NKI_A_PPFA5001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		5 / 9 HIS Z  49
GLU Z  51
ARG Z 490
HIS Z 385
THR Z 378
 A  B 108 ( 4.9A)
None
G  B 107 ( 2.9A)
G  B 107 ( 3.7A)
A  B 108 ( 3.2A)
 1.44A 1nkiA-5wtiZ:
undetectable
1nkiB-5wtiZ:
undetectable		 1nkiA-5wtiZ:
7.27
1nkiB-5wtiZ:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		3 / 3 GLU Z  51
HIS Z 385
HIS Z  49
 None
G  B 107 ( 3.7A)
A  B 108 ( 4.9A)
 0.41A 1oe2A-5wtiZ:
undetectable		 1oe2A-5wtiZ:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 8 ALA Z 803
ASP Z 574
ILE Z 573
ILE Z 855
 None
MG  Z1202 (-2.3A)
None
None
 0.93A 1p7lD-5wtiZ:
undetectable		 1p7lD-5wtiZ:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 8 ALA Z 803
ASP Z 574
ILE Z 573
ILE Z 855
 None
MG  Z1202 (-2.3A)
None
None
 0.93A 1rg9C-5wtiZ:
undetectable		 1rg9C-5wtiZ:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		5 / 9 LEU Z 276
GLN Z 273
GLU Z 266
SER Z 289
GLU Z 285
 None
 1.50A 1wrlA-5wtiZ:
undetectable
1wrlB-5wtiZ:
undetectable		 1wrlA-5wtiZ:
6.44
1wrlB-5wtiZ:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		5 / 9 LEU Z  69
LEU Z  40
ILE Z  37
PHE Z  72
LEU Z 186
 None
 1.27A 2f78A-5wtiZ:
undetectable		 2f78A-5wtiZ:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 8 GLU Z  68
ILE Z  65
GLU Z  48
ILE Z  46
 None
 0.90A 2j9dJ-5wtiZ:
undetectable
2j9dK-5wtiZ:
undetectable
2j9dL-5wtiZ:
undetectable		 2j9dJ-5wtiZ:
7.16
2j9dK-5wtiZ:
7.16
2j9dL-5wtiZ:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		5 / 10 ILE Z   7
PHE Z 510
GLY Z 482
ASN Z 515
TYR Z 402
 None
 1.40A 2piwA-5wtiZ:
undetectable		 2piwA-5wtiZ:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 6 VAL Z 870
ILE Z 855
ILE Z 825
LEU Z 826
 None
 0.82A 3hegA-5wtiZ:
undetectable		 3hegA-5wtiZ:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 5 PHE Z 616
ILE Z 585
GLY Z 805
HIS Z 802
 None
G  B  17 ( 4.0A)
G  B  17 ( 4.1A)
None
 1.17A 3r0lD-5wtiZ:
undetectable		 3r0lD-5wtiZ:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		3 / 3 PHE Z   6
SER Z 447
GLN Z 449
 None
G  B  42 ( 3.2A)
C  B 102 ( 3.7A)
 0.66A 3smtA-5wtiZ:
undetectable		 3smtA-5wtiZ:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		5 / 11 LEU Z 178
LEU Z 183
ILE Z 184
LEU Z 102
ILE Z  41
 None
 1.19A 4dm8A-5wtiZ:
undetectable		 4dm8A-5wtiZ:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 8 ALA Z 803
ASP Z 574
ILE Z 573
ILE Z 855
 None
MG  Z1202 (-2.3A)
None
None
 0.89A 4ndnB-5wtiZ:
undetectable		 4ndnB-5wtiZ:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 8 ALA Z 803
ASP Z 574
ILE Z 573
ILE Z 855
 None
MG  Z1202 (-2.3A)
None
None
 0.87A 4ndnD-5wtiZ:
undetectable		 4ndnD-5wtiZ:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		5 / 10 LEU Z 186
LEU Z 171
ILE Z 174
LEU Z 175
LEU Z  95
 None
 0.90A 4odoA-5wtiZ:
undetectable		 4odoA-5wtiZ:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		5 / 10 LEU Z 186
LEU Z 171
ILE Z 174
LEU Z 175
LEU Z  95
 None
 0.91A 4odoB-5wtiZ:
undetectable		 4odoB-5wtiZ:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		5 / 10 LEU Z 186
LEU Z 171
ILE Z 174
LEU Z 175
LEU Z  95
 None
 0.88A 4odoC-5wtiZ:
2.0		 4odoC-5wtiZ:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 7 ASN Z 398
TYR Z  34
LEU Z 224
PHE Z 227
 None
 1.00A 4yv5B-5wtiZ:
undetectable		 4yv5B-5wtiZ:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 7 ILE Z 800
GLY Z 867
THR Z 519
LEU Z 477
 None
 0.91A 4ze3A-5wtiZ:
undetectable		 4ze3A-5wtiZ:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		3 / 3 ALA Z 955
ASN Z 958
LEU Z 959
 None
 0.30A 5i1nB-5wtiZ:
undetectable		 5i1nB-5wtiZ:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		3 / 3 ALA Z 955
ASN Z 958
LEU Z 959
 None
 0.37A 5i1oC-5wtiZ:
undetectable		 5i1oC-5wtiZ:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		3 / 3 ALA Z 955
ASN Z 958
LEU Z 959
 None
 0.32A 5i1pA-5wtiZ:
undetectable		 5i1pA-5wtiZ:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 6 ASP Z  71
ASP Z  87
ASN Z  93
GLN Z  66
 None
 1.14A 5l6eA-5wtiZ:
undetectable		 5l6eA-5wtiZ:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3D_A_FCNA205_1
(FOSFOMYCIN
RESISTANCE PROTEIN)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		5 / 10 HIS Z 385
THR Z 378
HIS Z  49
GLU Z  51
ARG Z 490
 G  B 107 ( 3.7A)
A  B 108 ( 3.2A)
A  B 108 ( 4.9A)
None
G  B 107 ( 2.9A)
 1.48A 5v3dA-5wtiZ:
undetectable
5v3dB-5wtiZ:
undetectable		 5v3dA-5wtiZ:
8.84
5v3dB-5wtiZ:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5wti CRISPR-ASSOCIATED
PROTEIN
(Bacillus
thermoamylovoran
s) 		4 / 7 ALA Z 803
ASP Z 574
ILE Z 573
ILE Z 855
 None
MG  Z1202 (-2.3A)
None
None
 0.93A 6fbnA-5wtiZ:
undetectable		 6fbnA-5wtiZ:
17.01