SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wtk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 7 ILE A 532
PHE A 585
PHE A 589
PHE A 843
 None
 1.03A 1e71M-5wtkA:
undetectable		 1e71M-5wtkA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 7 ILE A 532
PHE A 585
PHE A 589
PHE A 843
 None
 1.02A 1e72M-5wtkA:
undetectable		 1e72M-5wtkA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		3 / 3 GLU A  42
LYS A  24
VAL A  25
 None
 0.85A 1l2iA-5wtkA:
1.5		 1l2iA-5wtkA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 8 ARG A 491
TYR A1241
GLU A1208
HIS A 483
 None
 1.19A 1nx9A-5wtkA:
undetectable		 1nx9A-5wtkA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 8 ARG A 491
TYR A1241
GLU A1208
HIS A 483
 None
 1.18A 1nx9B-5wtkA:
undetectable		 1nx9B-5wtkA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 8 ARG A 491
TYR A1241
GLU A1208
HIS A 483
 None
 1.16A 1nx9C-5wtkA:
undetectable		 1nx9C-5wtkA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 8 ARG A 491
TYR A1241
GLU A1208
HIS A 483
 None
 1.16A 1nx9D-5wtkA:
undetectable		 1nx9D-5wtkA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 5 ASP A1301
GLU A1298
LEU A1379
LEU A1342
 None
 1.15A 1u18B-5wtkA:
undetectable		 1u18B-5wtkA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		5 / 12 ILE A 707
ALA A 705
PHE A 795
ASN A 687
LEU A 683
 None
 1.44A 1u70A-5wtkA:
undetectable		 1u70A-5wtkA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		5 / 10 LEU A1174
GLU A1178
ILE A1079
ILE A1382
LEU A1378
 None
 1.07A 1wopA-5wtkA:
undetectable		 1wopA-5wtkA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 5 LEU A 792
LEU A 683
LEU A 681
LEU A 785
 None
 1.01A 1yajD-5wtkA:
undetectable		 1yajD-5wtkA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 7 SER A 841
ILE A 877
ASN A 622
ILE A 623
 None
 0.95A 1yc5A-5wtkA:
undetectable		 1yc5A-5wtkA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		3 / 3 ASN A 867
TYR A 669
SER A 863
 None
 0.93A 2gvcB-5wtkA:
undetectable		 2gvcB-5wtkA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		3 / 3 ASN A 867
TYR A 669
SER A 863
 None
 0.90A 2gvcE-5wtkA:
undetectable		 2gvcE-5wtkA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 6 ARG A 507
THR A 868
ASN A 665
ASP A 666
 None
 1.22A 2okcA-5wtkA:
undetectable		 2okcA-5wtkA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		3 / 3 ARG A1278
SER A1276
TYR A1225
 None
 0.92A 2q2hA-5wtkA:
undetectable
2q2hB-5wtkA:
undetectable		 2q2hA-5wtkA:
6.52
2q2hB-5wtkA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 6 ILE A 874
ARG A 608
ARG A 599
ILE A 600
 None
 1.16A 2q72A-5wtkA:
undetectable		 2q72A-5wtkA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 7 LEU A 435
GLU A 440
LEU A 443
TYR A 408
 None
G  B  17 ( 4.8A)
None
U  B  12 ( 4.2A)
 0.83A 2w8yA-5wtkA:
undetectable		 2w8yA-5wtkA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		5 / 9 THR A 308
PHE A 304
PHE A  75
GLU A 205
ILE A 204
 None
 1.38A 2w98A-5wtkA:
undetectable		 2w98A-5wtkA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		3 / 3 MET A 277
GLU A 301
ASN A 306
 None
 1.00A 3a27A-5wtkA:
undetectable		 3a27A-5wtkA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		3 / 3 TYR A1180
ASP A1167
ASP A1328
 None
 0.81A 3r24A-5wtkA:
undetectable		 3r24A-5wtkA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		5 / 12 ILE A 650
ILE A 654
LEU A 792
LEU A 706
ILE A 680
 None
 1.05A 3uvvA-5wtkA:
undetectable		 3uvvA-5wtkA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		5 / 12 ILE A  80
VAL A 298
ILE A 203
ILE A 207
VAL A 215
 None
 1.10A 3w68C-5wtkA:
undetectable		 3w68C-5wtkA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 7 ILE A1376
GLU A1350
PHE A1325
VAL A1303
 None
 0.91A 4a97A-5wtkA:
4.3		 4a97A-5wtkA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 7 ILE A1376
GLU A1350
PHE A1325
VAL A1303
 None
 0.89A 4a97D-5wtkA:
2.7		 4a97D-5wtkA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 7 LEU A 733
VAL A 777
TYR A 784
TYR A 781
 None
 1.12A 4b3qA-5wtkA:
undetectable		 4b3qA-5wtkA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		5 / 12 LEU A1349
PHE A1322
PHE A1325
MET A1353
ASP A1301
 None
 1.36A 4c9wA-5wtkA:
undetectable		 4c9wA-5wtkA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 5 HIS A 602
ALA A 603
HIS A 492
TYR A1241
 None
 1.18A 4gboA-5wtkA:
undetectable		 4gboA-5wtkA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 5 HIS A 602
ALA A 603
HIS A 492
TYR A1241
 None
 1.19A 4gboB-5wtkA:
undetectable		 4gboB-5wtkA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 8 ASN A 753
TYR A 755
GLU A 752
TYR A 781
 None
 1.16A 4mj8A-5wtkA:
undetectable
4mj8C-5wtkA:
undetectable		 4mj8A-5wtkA:
8.76
4mj8C-5wtkA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 8 ILE A 855
GLU A 517
ILE A 519
LEU A 516
 None
 0.93A 4mj8A-5wtkA:
undetectable		 4mj8A-5wtkA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		3 / 3 GLU A 346
TYR A 479
GLU A 426
 None
 0.81A 4ryaA-5wtkA:
undetectable		 4ryaA-5wtkA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		5 / 11 ASP A 646
PHE A 798
VAL A 702
ILE A 821
ILE A 651
 None
 1.35A 5hw8B-5wtkA:
undetectable		 5hw8B-5wtkA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		5 / 12 PHE A1340
LEU A1331
LEU A1342
ILE A1375
THR A1317
 None
 1.18A 5ienB-5wtkA:
undetectable		 5ienB-5wtkA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		5 / 10 ILE A 842
LEU A 845
ILE A 852
ILE A 881
ILE A 874
 None
 1.03A 5mvmD-5wtkA:
undetectable
5mvmE-5wtkA:
4.1		 5mvmD-5wtkA:
4.06
5mvmE-5wtkA:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		5 / 12 LEU A 383
LEU A 463
SER A 466
SER A 469
LEU A 375
 None
 1.17A 5mwyA-5wtkA:
undetectable		 5mwyA-5wtkA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 5 HIS A 602
ALA A 603
HIS A 492
TYR A1241
 None
 1.16A 5uizA-5wtkA:
undetectable		 5uizA-5wtkA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		5 / 12 MET A1192
SER A1320
GLU A1323
ILE A1184
PHE A1322
 None
A  B  25 ( 4.9A)
A  B  26 ( 3.4A)
None
None
 1.45A 5vlmA-5wtkA:
0.9		 5vlmA-5wtkA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2
(Leptotrichia
shahii) 		4 / 5 ASP A1301
ILE A1286
ASN A1314
TYR A1318
 None
None
C  B   2 ( 4.5A)
None
 1.21A 6a93B-5wtkA:
4.5		 6a93B-5wtkA:
13.78