SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wu3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 11 ALA A 560
LEU A 563
LEU A 539
LEU A 512
ALA A 433
 None
 1.11A 1h9zA-5wu3A:
1.7		 1h9zA-5wu3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 7 LEU A 341
VAL A 344
GLY A 345
ASP A 381
 None
 0.68A 1p2yA-5wu3A:
undetectable		 1p2yA-5wu3A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 11 VAL A 449
ASN A 487
ARG A 405
GLU A 489
ASP A 403
 None
 1.31A 1t6zA-5wu3A:
undetectable		 1t6zA-5wu3A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 7 LEU A 341
VAL A 344
GLY A 345
ASP A 381
 None
 0.62A 1t88A-5wu3A:
undetectable		 1t88A-5wu3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 7 ILE A 439
LEU A 450
THR A 457
LEU A 456
 None
 0.92A 1v54N-5wu3A:
undetectable
1v54W-5wu3A:
undetectable		 1v54N-5wu3A:
22.06
1v54W-5wu3A:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 8 LEU A 341
VAL A 344
GLY A 345
ASP A 381
 None
 0.55A 2a1oA-5wu3A:
undetectable		 2a1oA-5wu3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 6 LEU A 511
LEU A 520
LEU A 530
LEU A 547
 None
 1.05A 2ab2A-5wu3A:
undetectable		 2ab2A-5wu3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 5 LEU A 511
LEU A 520
LEU A 530
LEU A 547
 None
 1.05A 2ab2B-5wu3A:
undetectable		 2ab2B-5wu3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 12 GLY A 354
MET A 187
PHE A 191
PHE A 371
VAL A 344
 None
 1.31A 2fqyA-5wu3A:
undetectable		 2fqyA-5wu3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		3 / 3 SER A 548
HIS A 391
ASP A 222
 None
 0.59A 2oxtA-5wu3A:
undetectable		 2oxtA-5wu3A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 7 LEU A 396
THR A 435
VAL A 551
ASP A 543
 None
EDO  A1004 (-3.7A)
UTP  A1001 ( 4.4A)
None
 0.96A 2qblA-5wu3A:
undetectable		 2qblA-5wu3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 12 ALA A 417
GLY A 419
LEU A 413
GLY A 424
SER A 423
 None
 1.08A 3g2oA-5wu3A:
undetectable		 3g2oA-5wu3A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 12 ALA A 417
GLY A 419
LEU A 413
GLY A 424
SER A 423
 None
 1.09A 3g2oB-5wu3A:
undetectable		 3g2oB-5wu3A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		3 / 3 ARG A 420
THR A 556
THR A 844
 None
 0.77A 3k2hB-5wu3A:
undetectable		 3k2hB-5wu3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 11 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
 None
 1.13A 3pghB-5wu3A:
undetectable		 3pghB-5wu3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		6 / 12 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.27A 3pghD-5wu3A:
undetectable		 3pghD-5wu3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 5 LEU A 862
PHE A 865
PRO A 867
ALA A 869
 None
 1.33A 3vm4A-5wu3A:
undetectable		 3vm4A-5wu3A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 5 SER A 206
ARG A 180
LEU A 217
ASP A 216
 None
None
None
MG  A1002 ( 3.8A)
 1.43A 4ifxA-5wu3A:
1.9		 4ifxA-5wu3A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 5 SER A 206
ARG A 180
LEU A 217
ASP A 216
 None
None
None
MG  A1002 ( 3.8A)
 1.44A 4ig1A-5wu3A:
undetectable		 4ig1A-5wu3A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 4 LEU A 402
SER A 400
LEU A 442
LEU A 456
 None
 1.08A 4n09A-5wu3A:
undetectable		 4n09A-5wu3A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 11 SER A 583
GLN A 578
ALA A 156
ALA A 154
ASP A 588
 None
 1.34A 5bxnV-5wu3A:
undetectable
5bxnW-5wu3A:
undetectable		 5bxnV-5wu3A:
18.12
5bxnW-5wu3A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		6 / 12 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.30A 5ikrB-5wu3A:
undetectable		 5ikrB-5wu3A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		6 / 12 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.26A 5jvzA-5wu3A:
0.0		 5jvzA-5wu3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 8 THR A 435
ASN A 392
PHE A 395
PRO A 544
 EDO  A1004 (-3.7A)
UTP  A1001 (-2.6A)
None
None
 1.18A 5v4vA-5wu3A:
undetectable		 5v4vA-5wu3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 8 THR A 435
ASN A 392
PHE A 395
PRO A 544
 EDO  A1004 (-3.7A)
UTP  A1001 (-2.6A)
None
None
 1.19A 5v4vB-5wu3A:
undetectable		 5v4vB-5wu3A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 8 ILE A 439
LEU A 450
THR A 457
LEU A 456
 None
 0.90A 5zcoA-5wu3A:
undetectable
5zcoJ-5wu3A:
undetectable		 5zcoA-5wu3A:
22.06
5zcoJ-5wu3A:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 8 ILE A 635
THR A 811
VAL A 810
GLU A 807
 None
 0.99A 6fbvC-5wu3A:
undetectable		 6fbvC-5wu3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 12 SER A 583
GLN A 578
ALA A 157
ALA A 154
ASP A 588
 None
 1.07A 6hwdH-5wu3A:
undetectable
6hwdI-5wu3A:
undetectable		 6hwdH-5wu3A:
9.46
6hwdI-5wu3A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 5 HIS A 391
VAL A 468
ARG A 394
PHE A 220
 None
 1.15A 6hxiB-5wu3A:
undetectable		 6hxiB-5wu3A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		3 / 3 ARG A 405
LEU A 494
PHE A 498
 None
 0.77A 6nknP-5wu3A:
undetectable		 6nknP-5wu3A:
18.84