SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wu6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 12 LEU A 434
LEU A 413
VAL A 502
ALA A 570
ALA A 571
 None
 1.18A 1n5xA-5wu6A:
undetectable		 1n5xA-5wu6A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 12 LEU A 434
LEU A 413
VAL A 502
ALA A 570
ALA A 571
 None
 1.18A 1n5xB-5wu6A:
undetectable		 1n5xB-5wu6A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 7 LEU A 341
VAL A 344
GLY A 345
ASP A 381
 None
None
None
MG  A1001 (-3.9A)
 0.70A 1p2yA-5wu6A:
undetectable		 1p2yA-5wu6A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 11 VAL A 449
ASN A 487
ARG A 405
GLU A 489
ASP A 403
 None
 1.34A 1t6zA-5wu6A:
undetectable		 1t6zA-5wu6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 7 LEU A 341
VAL A 344
GLY A 345
ASP A 381
 None
None
None
MG  A1001 (-3.9A)
 0.61A 1t88A-5wu6A:
undetectable		 1t88A-5wu6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 4 LEU A 520
LEU A 526
SER A 528
LEU A 536
 None
 1.06A 1ya3A-5wu6A:
undetectable		 1ya3A-5wu6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 8 LEU A 341
VAL A 344
GLY A 345
ASP A 381
 None
None
None
MG  A1001 (-3.9A)
 0.56A 2a1oA-5wu6A:
undetectable		 2a1oA-5wu6A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 12 GLY A 354
MET A 187
PHE A 191
PHE A 371
VAL A 344
 None
 1.34A 2fqyA-5wu6A:
undetectable		 2fqyA-5wu6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		3 / 3 SER A 548
HIS A 391
ASP A 222
 None
 0.59A 2oxtA-5wu6A:
undetectable		 2oxtA-5wu6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 7 LEU A 396
THR A 435
VAL A 551
ASP A 543
 None
 0.97A 2qblA-5wu6A:
undetectable		 2qblA-5wu6A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 4 LEU A 511
PRO A 527
LEU A 536
ARG A 535
 None
 1.45A 2qd2A-5wu6A:
undetectable		 2qd2A-5wu6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 8 VAL A 453
PHE A 395
HIS A 391
VAL A 468
 None
 1.01A 3fhxB-5wu6A:
undetectable		 3fhxB-5wu6A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 8 LEU A 547
GLN A 542
SER A 513
ARG A 515
 None
 1.07A 3kp2A-5wu6A:
undetectable
3kp2B-5wu6A:
undetectable		 3kp2A-5wu6A:
15.27
3kp2B-5wu6A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		6 / 12 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.33A 3nt1A-5wu6A:
undetectable		 3nt1A-5wu6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		6 / 12 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.33A 3nt1B-5wu6A:
undetectable		 3nt1B-5wu6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		5 / 11 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
 None
 1.14A 3pghB-5wu6A:
undetectable		 3pghB-5wu6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		6 / 12 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.29A 3pghD-5wu6A:
undetectable		 3pghD-5wu6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 6 ARG A 481
GLU A 401
LEU A 398
ASP A 478
 None
 1.28A 4cevA-5wu6A:
undetectable
4cevB-5wu6A:
undetectable		 4cevA-5wu6A:
20.66
4cevB-5wu6A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 6 ASP A 478
ARG A 481
GLU A 401
LEU A 398
 None
 1.28A 4cevA-5wu6A:
undetectable
4cevC-5wu6A:
undetectable		 4cevA-5wu6A:
20.66
4cevC-5wu6A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 6 ARG A 481
GLU A 401
LEU A 398
ASP A 478
 None
 1.27A 4cevD-5wu6A:
undetectable
4cevE-5wu6A:
undetectable		 4cevD-5wu6A:
20.66
4cevE-5wu6A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 6 ARG A 481
GLU A 401
LEU A 398
ASP A 478
 None
 1.26A 4cevE-5wu6A:
undetectable
4cevF-5wu6A:
undetectable		 4cevE-5wu6A:
20.66
4cevF-5wu6A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 4 LEU A 402
SER A 400
LEU A 442
LEU A 456
 None
 1.03A 4n09A-5wu6A:
undetectable		 4n09A-5wu6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		6 / 12 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.30A 5ikrB-5wu6A:
undetectable		 5ikrB-5wu6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		6 / 12 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.27A 5jvzA-5wu6A:
undetectable		 5jvzA-5wu6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		6 / 12 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
 None
 1.31A 5jw1B-5wu6A:
undetectable		 5jw1B-5wu6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 8 THR A 435
ASN A 392
PHE A 395
PRO A 544
 None
 1.25A 5v4vA-5wu6A:
undetectable		 5v4vA-5wu6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 8 THR A 435
ASN A 392
PHE A 395
PRO A 544
 None
 1.26A 5v4vB-5wu6A:
undetectable		 5v4vB-5wu6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		4 / 5 ARG A 477
PHE A 395
LEU A 398
LEU A 390
 None
 1.30A 5veuH-5wu6A:
undetectable		 5veuH-5wu6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens) 		3 / 3 ARG A 405
LEU A 494
PHE A 498
 None
 0.81A 6nknP-5wu6A:
undetectable		 6nknP-5wu6A:
19.88