SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wu7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_2
(GLUCOAMYLASE-471)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 SER A 294
TRP A 362
GLU A  31
LEU A 472
 None
 1.44A 1agmA-5wu7A:
undetectable		 1agmA-5wu7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 530
ALA A 440
MET A 436
PHE A 504
LEU A 461
 None
 1.28A 1brpA-5wu7A:
undetectable		 1brpA-5wu7A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ALA A 259
ILE A 387
GLY A 180
ILE A 181
VAL A 222
 None
 1.09A 1d4yA-5wu7A:
undetectable		 1d4yA-5wu7A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 GLU A  49
GLU A  45
LEU A 132
GLU A 135
 None
 1.03A 1linA-5wu7A:
undetectable		 1linA-5wu7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 LEU A 464
MET A 484
LEU A 487
GLN A 470
 None
 1.36A 1p93D-5wu7A:
undetectable		 1p93D-5wu7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 145
LEU A 150
THR A 142
ILE A 181
LEU A 212
 None
 1.11A 1rg7A-5wu7A:
undetectable		 1rg7A-5wu7A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 PHE A  60
SER A  59
THR A 356
THR A  11
 None
 0.89A 1sbrA-5wu7A:
undetectable		 1sbrA-5wu7A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 PHE A  60
SER A  59
THR A 356
THR A  11
 None
 0.91A 1sbrB-5wu7A:
undetectable		 1sbrB-5wu7A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ILE A 524
HIS A 489
GLU A 460
HIS A  19
 None
 0.88A 1y93A-5wu7A:
undetectable		 1y93A-5wu7A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 LEU A 163
GLN A 162
LEU A 212
PHE A 220
 None
 1.04A 2einP-5wu7A:
3.1
2einW-5wu7A:
undetectable		 2einP-5wu7A:
16.58
2einW-5wu7A:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ALA A 259
ILE A 387
GLY A 180
ILE A 181
VAL A 222
 None
 1.00A 2o4pA-5wu7A:
undetectable		 2o4pA-5wu7A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 LEU A 337
ILE A 330
SER A 380
GLY A 381
 None
 0.95A 2otfA-5wu7A:
undetectable		 2otfA-5wu7A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LEU A 183
PRO A 184
ARG A 189
 None
 0.66A 2qd4B-5wu7A:
undetectable		 2qd4B-5wu7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 TRP A 469
ILE A 486
ARG A 485
LEU A 464
 None
 0.96A 2rlfA-5wu7A:
undetectable
2rlfD-5wu7A:
undetectable		 2rlfA-5wu7A:
6.16
2rlfD-5wu7A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 GLU A 511
HIS A 494
HIS A 491
 None
 0.87A 3co4A-5wu7A:
6.2		 3co4A-5wu7A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 4 PRO A 404
TYR A 188
GLY A 406
THR A 413
 None
 1.41A 3ib0A-5wu7A:
undetectable		 3ib0A-5wu7A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 GLU A 365
TYR A 110
PHE A 106
TYR A 313
 None
 1.05A 3ku9B-5wu7A:
undetectable		 3ku9B-5wu7A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 PHE A 329
PHE A   7
TYR A 354
VAL A 333
 None
 1.27A 3lb3B-5wu7A:
undetectable		 3lb3B-5wu7A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		6 / 10 LEU A 403
ALA A 259
ILE A 387
GLY A 180
ILE A 181
VAL A 222
 None
 1.31A 3lzvA-5wu7A:
undetectable		 3lzvA-5wu7A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ALA A 259
ILE A 387
GLY A 180
ILE A 181
VAL A 222
 None
 0.96A 3lzvB-5wu7A:
undetectable		 3lzvB-5wu7A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PHE A 329
ILE A 349
ALA A 352
THR A   6
ILE A 387
 None
 1.30A 3ndiA-5wu7A:
undetectable		 3ndiA-5wu7A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 ALA A 259
ILE A 387
GLY A 180
ILE A 181
VAL A 222
 None
 1.10A 3ndwB-5wu7A:
undetectable		 3ndwB-5wu7A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ALA A 259
ILE A 387
GLY A 180
ILE A 181
VAL A 222
 None
 0.93A 3nu6A-5wu7A:
undetectable		 3nu6A-5wu7A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ALA A 259
ILE A 387
GLY A 180
ILE A 181
VAL A 222
 None
 0.98A 3nujA-5wu7A:
undetectable		 3nujA-5wu7A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 ALA A 259
ILE A 387
GLY A 180
ILE A 181
VAL A 222
 None
 0.97A 3nuoA-5wu7A:
undetectable		 3nuoA-5wu7A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LYS A 255
ARG A 246
LEU A 403
 None
 1.42A 3v4tE-5wu7A:
undetectable		 3v4tE-5wu7A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 TRP A 426
ARG A 205
HIS A 430
HIS A 414
 None
 1.38A 3zodA-5wu7A:
undetectable		 3zodA-5wu7A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 LEU A 550
HIS A 491
HIS A  19
HIS A 489
 None
 1.37A 4a7bB-5wu7A:
undetectable		 4a7bB-5wu7A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 HIS A  12
GLU A 185
ASP A 468
SER A 467
 None
 1.31A 4apjA-5wu7A:
2.6
4apjP-5wu7A:
undetectable		 4apjA-5wu7A:
22.91
4apjP-5wu7A:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 HIS A  12
GLU A 185
SER A 467
PRO A 184
 None
 1.19A 4apjA-5wu7A:
2.6
4apjP-5wu7A:
undetectable		 4apjA-5wu7A:
22.91
4apjP-5wu7A:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 LEU A  44
LYS A  48
LEU A 132
GLU A 135
 None
 1.03A 4f3tA-5wu7A:
undetectable		 4f3tA-5wu7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 LEU A 514
LEU A 496
GLU A 460
TYR A 492
 None
 1.14A 4f3tA-5wu7A:
undetectable		 4f3tA-5wu7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 LEU A 334
ILE A 336
ILE A 382
GLY A   3
GLY A 348
 None
 0.95A 4fakA-5wu7A:
2.6		 4fakA-5wu7A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 TYR A  37
LEU A  29
VAL A  16
LEU A 126
 None
 0.93A 4l1xA-5wu7A:
3.3		 4l1xA-5wu7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 LYS A  48
LEU A 132
GLU A 135
TYR A 137
 None
 1.24A 4olaA-5wu7A:
undetectable		 4olaA-5wu7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 158
LEU A 461
ILE A  73
THR A  11
PHE A 525
 None
 1.15A 5eshA-5wu7A:
undetectable		 5eshA-5wu7A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ILE A 258
PHE A 253
PHE A 221
THR A   6
 None
 1.15A 5g08A-5wu7A:
undetectable		 5g08A-5wu7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 VAL A 140
LEU A  29
MET A  33
 None
 0.73A 5ikrA-5wu7A:
undetectable		 5ikrA-5wu7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 LYS A  48
LEU A 132
GLU A 135
TYR A 137
 None
 1.24A 5js1A-5wu7A:
undetectable		 5js1A-5wu7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 ALA A 259
ILE A 387
GLY A 180
ILE A 181
VAL A 222
 None
 1.05A 5kr0A-5wu7A:
undetectable		 5kr0A-5wu7A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 9 PHE A 394
VAL A 385
THR A   6
ILE A 349
 None
 0.80A 5lg3I-5wu7A:
3.2		 5lg3I-5wu7A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ILE A 524
HIS A 489
GLU A 460
HIS A  19
 None
 0.92A 5n5kA-5wu7A:
undetectable		 5n5kA-5wu7A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 GLU A  90
LYS A  86
GLU A  89
GLU A  93
 None
 0.95A 5onlA-5wu7A:
undetectable		 5onlA-5wu7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 LEU A  44
LYS A  48
LEU A 132
GLU A 135
 None
 1.07A 5t7bA-5wu7A:
undetectable		 5t7bA-5wu7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 SER A  59
LEU A 183
ILE A 167
PRO A 178
SER A 143
 None
 1.46A 6dm2B-5wu7A:
3.3
6dm2C-5wu7A:
1.9		 6dm2B-5wu7A:
10.17
6dm2C-5wu7A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ILE A 167
PRO A 178
SER A 143
SER A  59
LEU A 183
 None
 1.47A 6dm2A-5wu7A:
1.9
6dm2D-5wu7A:
2.7		 6dm2A-5wu7A:
10.17
6dm2D-5wu7A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 GLY A 331
LEU A 334
VAL A 271
PHE A 359
 None
 1.03A 6h7lA-5wu7A:
2.4		 6h7lA-5wu7A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 GLY A 331
LEU A 334
VAL A 271
PHE A 359
 None
 1.04A 6h7lB-5wu7A:
undetectable		 6h7lB-5wu7A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 5wu7 UNCHARACTERIZED
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 GLU A  90
LYS A  86
GLU A  89
GLU A  93
 None
 0.97A 6hrjA-5wu7A:
undetectable		 6hrjA-5wu7A:
17.96