SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wuf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5wuf PUTATIVE MEMBRANE
PROTEIN
(Colwellia
psychrerythraea) 		5 / 12 LEU A 153
ALA A 155
ALA A 103
THR A 107
LEU A   8
 None
 1.19A 1cbrA-5wufA:
undetectable		 1cbrA-5wufA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5wuf PUTATIVE MEMBRANE
PROTEIN
(Colwellia
psychrerythraea) 		5 / 12 LEU A 153
ALA A 155
ALA A 103
THR A 107
LEU A   8
 None
 1.19A 1cbrB-5wufA:
undetectable		 1cbrB-5wufA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wuf PUTATIVE MEMBRANE
PROTEIN
(Colwellia
psychrerythraea) 		5 / 12 GLY A  33
SER A  39
ALA A  17
ILE A  69
LEU A  70
 CD  A 301 ( 4.2A)
None
None
None
None
 1.16A 3adsB-5wufA:
undetectable		 3adsB-5wufA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5wuf PUTATIVE MEMBRANE
PROTEIN
(Colwellia
psychrerythraea) 		5 / 11 VAL A  13
ALA A  42
THR A  72
ILE A  69
ARG A  26
 None
 1.39A 3n23A-5wufA:
undetectable		 3n23A-5wufA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5wuf PUTATIVE MEMBRANE
PROTEIN
(Colwellia
psychrerythraea) 		5 / 12 GLY A  20
GLY A 132
SER A  19
LEU A  18
ALA A  38
 None
 0.86A 4uciA-5wufA:
undetectable		 4uciA-5wufA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5wuf PUTATIVE MEMBRANE
PROTEIN
(Colwellia
psychrerythraea) 		5 / 12 GLY A  20
GLY A 132
SER A  19
LEU A  18
ALA A  38
 None
 0.86A 4uciB-5wufA:
undetectable		 4uciB-5wufA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5wuf PUTATIVE MEMBRANE
PROTEIN
(Colwellia
psychrerythraea) 		5 / 12 GLY A  20
GLY A 132
SER A  19
LEU A  18
ALA A  38
 None
 0.88A 4uckA-5wufA:
undetectable		 4uckA-5wufA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 5wuf PUTATIVE MEMBRANE
PROTEIN
(Colwellia
psychrerythraea) 		5 / 10 PHE A 102
TYR A 151
GLY A  12
PHE A  16
GLY A  45
 None
 1.39A 4xpbA-5wufA:
undetectable		 4xpbA-5wufA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wuf PUTATIVE MEMBRANE
PROTEIN
(Colwellia
psychrerythraea) 		6 / 11 GLY A  33
SER A  39
ALA A  17
ILE A  69
LEU A  70
ILE A  77
 CD  A 301 ( 4.2A)
None
None
None
None
None
 1.41A 4xumB-5wufA:
undetectable		 4xumB-5wufA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5wuf PUTATIVE MEMBRANE
PROTEIN
(Colwellia
psychrerythraea) 		3 / 3 LEU A  22
ARG A 135
ARG A  26
 None
 0.91A 4yiaB-5wufA:
undetectable		 4yiaB-5wufA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 5wuf PUTATIVE MEMBRANE
PROTEIN
(Colwellia
psychrerythraea) 		5 / 10 ALA A 190
LEU A  92
ALA A  96
LEU A 153
ALA A 154
 None
 1.07A 4zbrA-5wufA:
undetectable		 4zbrA-5wufA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5wuf PUTATIVE MEMBRANE
PROTEIN
(Colwellia
psychrerythraea) 		4 / 5 VAL A  13
VAL A  43
GLY A  44
PHE A  58
 None
 1.12A 5d4nA-5wufA:
undetectable
5d4nC-5wufA:
undetectable		 5d4nA-5wufA:
16.47
5d4nC-5wufA:
16.47