SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wuq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 5wuq ANTI-SIGMA-W FACTOR
RSIW
(Bacillus
subtilis) 		3 / 3 CYH C   3
CYH C  37
HIS C  30
 ZN  C 301 (-2.3A)
ZN  C 301 (-2.3A)
ZN  C 301 (-3.7A)
 0.64A 2iwkA-5wuqC:
undetectable		 2iwkA-5wuqC:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 5wuq ANTI-SIGMA-W FACTOR
RSIW
(Bacillus
subtilis) 		3 / 3 CYH C   3
CYH C  37
HIS C  30
 ZN  C 301 (-2.3A)
ZN  C 301 (-2.3A)
ZN  C 301 (-3.7A)
 0.65A 2iwkB-5wuqC:
undetectable		 2iwkB-5wuqC:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		4 / 7 VAL A 166
LYS A 170
ILE A 173
GLY A 176
 None
 0.89A 3bjwB-5wuqA:
2.2		 3bjwB-5wuqA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		5 / 12 ALA A  52
LEU A  34
GLN A  33
ILE A 161
LEU A 153
 None
 1.13A 3datA-5wuqA:
undetectable		 3datA-5wuqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		4 / 6 THR A 143
ILE A 158
LEU A 162
THR A  78
 None
 0.95A 3deuB-5wuqA:
3.1		 3deuB-5wuqA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5wuq ANTI-SIGMA-W FACTOR
RSIW
(Bacillus
subtilis) 		3 / 3 CYH C   3
CYH C  37
HIS C  30
 ZN  C 301 (-2.3A)
ZN  C 301 (-2.3A)
ZN  C 301 (-3.7A)
 0.73A 3dtuB-5wuqC:
undetectable		 3dtuB-5wuqC:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5wuq ANTI-SIGMA-W FACTOR
RSIW
(Bacillus
subtilis) 		3 / 3 CYH C   3
CYH C  37
HIS C  30
 ZN  C 301 (-2.3A)
ZN  C 301 (-2.3A)
ZN  C 301 (-3.7A)
 0.71A 3dtuD-5wuqC:
undetectable		 3dtuD-5wuqC:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		5 / 12 ALA A  52
LEU A  34
GLN A  33
ILE A 161
LEU A 153
 None
 1.12A 3ia4A-5wuqA:
undetectable		 3ia4A-5wuqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		5 / 12 ALA A  52
LEU A  34
GLN A  33
LYS A  30
ILE A 161
 None
 1.29A 3ia4A-5wuqA:
undetectable		 3ia4A-5wuqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		5 / 12 ALA A  52
LEU A  34
GLN A  33
ILE A 161
LEU A 153
 None
 1.10A 3ia4B-5wuqA:
undetectable		 3ia4B-5wuqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		5 / 12 ALA A  52
LEU A  34
GLN A  33
ILE A 161
LEU A 153
 None
 1.14A 3ia4C-5wuqA:
undetectable		 3ia4C-5wuqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		5 / 12 ALA A  52
LEU A  34
GLN A  33
LYS A  30
ILE A 161
 None
 1.21A 3ia4C-5wuqA:
undetectable		 3ia4C-5wuqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5wuq ANTI-SIGMA-W FACTOR
RSIW
ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		4 / 7 ASP C  16
ILE A 145
VAL C  51
ARG C  52
 None
 1.10A 3p6hA-5wuqC:
undetectable		 3p6hA-5wuqC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 5wuq ANTI-SIGMA-W FACTOR
RSIW
ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		3 / 3 HIS C  12
ARG A 177
GLU A 178
 None
 1.12A 3qf1A-5wuqC:
undetectable		 3qf1A-5wuqC:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		5 / 12 ALA A 179
LYS A 182
LEU A 184
ILE A 134
ILE A 130
 None
 1.13A 3ut5B-5wuqA:
undetectable		 3ut5B-5wuqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		3 / 3 LYS A  68
THR A  71
ILE A 158
 None
 0.92A 4e0fB-5wuqA:
undetectable		 4e0fB-5wuqA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
ANTI-SIGMA-W FACTOR
RSIW
(Bacillus
subtilis;
Bacillus
subtilis) 		5 / 12 PHE C  63
ALA A  52
ARG A 142
CYH A  35
ILE A  31
 None
 1.11A 4krhA-5wuqC:
undetectable		 4krhA-5wuqC:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
ANTI-SIGMA-W FACTOR
RSIW
(Bacillus
subtilis;
Bacillus
subtilis) 		5 / 12 PHE C  63
ALA A  52
ARG A 142
CYH A  35
ILE A  31
 None
 1.10A 4krhB-5wuqC:
undetectable		 4krhB-5wuqC:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		4 / 4 ILE A 134
VAL A 144
VAL A 146
ARG A  37
 None
 1.03A 4m6tA-5wuqA:
undetectable		 4m6tA-5wuqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW
(Bacillus
subtilis) 		5 / 9 LEU A 153
ILE A 161
GLY A 159
LEU A 162
ILE A  85
 None
 0.96A 5vkqC-5wuqA:
undetectable
5vkqD-5wuqA:
undetectable		 5vkqC-5wuqA:
7.23
5vkqD-5wuqA:
7.23