SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 12 SER A 144
TYR A 158
GLY A 189
PRO A 190
PHE A 247
 None
 1.22A 1fdsA-5wvaA:
26.7		 1fdsA-5wvaA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 12 TYR A 158
ILE A  21
GLY A 143
SER A 161
GLY A 189
 None
 0.98A 1kiaA-5wvaA:
7.8		 1kiaA-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 12 TYR A 158
ILE A  21
GLY A 143
SER A 161
GLY A 189
 None
 1.01A 1nbhB-5wvaA:
7.3		 1nbhB-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 12 TYR A 158
ILE A  21
GLY A 143
SER A 161
GLY A 189
 None
 1.09A 1nbiA-5wvaA:
7.4		 1nbiA-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 12 TYR A 158
ILE A  21
GLY A 143
SER A 161
GLY A 189
 None
 1.08A 1nbiB-5wvaA:
7.6		 1nbiB-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 10 PHE A 123
ALA A 129
LEU A  91
ASP A 175
LEU A 176
 None
 1.08A 1yi4A-5wvaA:
undetectable		 1yi4A-5wvaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		4 / 8 ILE A 243
SER A 242
ARG A 214
GLU A 220
 None
 0.67A 2cdqA-5wvaA:
undetectable		 2cdqA-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 12 ILE A  25
ALA A  24
GLY A  20
ILE A 221
GLY A  16
 None
 0.86A 2qe6B-5wvaA:
6.4		 2qe6B-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 10 ALA A  66
ILE A  64
GLY A  16
VAL A 124
LEU A  74
 None
 0.98A 3ogpA-5wvaA:
undetectable		 3ogpA-5wvaA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		4 / 5 THR A  39
ILE A  64
PHE A  13
LEU A  74
 None
 1.39A 3tf1A-5wvaA:
undetectable		 3tf1A-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		4 / 8 GLY A  22
ASP A 218
GLY A  20
VAL A  50
 None
 0.83A 4c5nC-5wvaA:
7.1		 4c5nC-5wvaA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 11 ILE A 236
ALA A 239
GLY A 238
GLY A 143
ASN A 184
 None
 1.22A 4e47A-5wvaA:
undetectable		 4e47A-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 11 ILE A 236
ALA A 239
GLY A 238
GLY A 143
ASN A 184
 None
 1.18A 4e47B-5wvaA:
undetectable		 4e47B-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 11 ILE A 236
ALA A 239
GLY A 238
GLY A 143
ASN A 184
 None
 1.22A 4e47C-5wvaA:
undetectable		 4e47C-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		3 / 3 ARG A 179
TYR A 235
ASN A 184
 None
 0.84A 4ffwB-5wvaA:
2.9		 4ffwB-5wvaA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 12 GLY A  22
GLY A  17
GLY A  16
ALA A 222
VAL A 191
 None
 0.93A 4htfA-5wvaA:
2.6		 4htfA-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 11 ILE A 236
ALA A 239
GLY A 238
GLY A 143
ASN A 184
 None
 1.19A 4jdsA-5wvaA:
undetectable		 4jdsA-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 11 ILE A 236
ALA A 239
GLY A 238
GLY A 143
ASN A 184
 None
 1.19A 4jdsB-5wvaA:
undetectable		 4jdsB-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 11 ILE A 236
ALA A 239
GLY A 238
GLY A 143
ASN A 184
 None
 1.21A 4jdsC-5wvaA:
undetectable		 4jdsC-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 12 ILE A 236
ALA A 239
GLY A 238
GLY A 143
ASN A 184
 None
 1.23A 4jlgA-5wvaA:
undetectable		 4jlgA-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 11 ILE A 236
ALA A 239
GLY A 238
GLY A 143
ASN A 184
 None
 1.18A 5ayfA-5wvaA:
undetectable		 5ayfA-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 12 TYR A 158
SER A 161
THR A 145
ALA A 147
ASN A 185
 None
 1.38A 5dsgA-5wvaA:
undetectable		 5dsgA-5wvaA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 12 TYR A 158
SER A 161
THR A 145
ALA A 147
ASN A 185
 None
 1.39A 5dsgB-5wvaA:
undetectable		 5dsgB-5wvaA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		4 / 5 VAL A  82
ASN A 134
ASP A  89
LEU A  88
 None
 1.05A 5m0iB-5wvaA:
undetectable		 5m0iB-5wvaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5wva SHORT-CHAIN
DEHYDROGENASE
(Serratia
marcescens) 		5 / 9 ILE A 236
ALA A 239
GLY A 238
GLY A 143
ASN A 184
 None
 1.16A 6nm4B-5wvaA:
undetectable		 6nm4B-5wvaA:
undetectable