SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 8 GLY A 319
GLU A 283
SER A 284
HIS A 438
 None
 1.02A 1maaD-5wveA:
undetectable		 1maaD-5wveA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5wve CASPASE
(Homo
sapiens) 		5 / 11 LEU S  89
LEU S  20
LEU S  25
LEU S   9
LEU S  16
 None
 1.42A 1mx1B-5wveS:
undetectable		 1mx1B-5wveS:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		5 / 10 SER A 918
LEU A 866
VAL A 856
PHE A 897
VAL A 914
 None
 1.45A 1q23K-5wveA:
undetectable		 1q23K-5wveA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 SER A 891
ASP A 893
SER A 895
SER A 896
 None
 0.96A 2cmlA-5wveA:
7.8		 2cmlA-5wveA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 8 SER A 891
ASP A 893
SER A 895
SER A 896
 None
 1.04A 2cmlB-5wveA:
3.0		 2cmlB-5wveA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 8 SER A 891
ASP A 893
SER A 895
SER A 896
 None
 0.92A 2cmlC-5wveA:
8.9		 2cmlC-5wveA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 8 SER A 891
ASP A 893
SER A 895
SER A 896
 None
 0.94A 2cmlD-5wveA:
4.5		 2cmlD-5wveA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		5 / 11 MET A 231
LEU A 206
LEU A 202
LEU A 242
VAL A 187
 None
 1.33A 2po5B-5wveA:
2.8		 2po5B-5wveA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		5 / 12 GLN A 565
PHE A 560
THR A1212
GLY A 567
LEU A 507
 None
 1.47A 3aobC-5wveA:
undetectable		 3aobC-5wveA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		5 / 11 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
 1.19A 3bgrA-5wveA:
undetectable
3bgrB-5wveA:
undetectable		 3bgrA-5wveA:
19.67
3bgrB-5wveA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 VAL A 127
VAL A 324
PHE A 298
GLU A 293
 DTP  A1301 (-4.1A)
None
None
None
 1.27A 3dqrA-5wveA:
undetectable
3dqrB-5wveA:
undetectable		 3dqrA-5wveA:
15.34
3dqrB-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.27A 3dqrA-5wveA:
undetectable
3dqrB-5wveA:
undetectable		 3dqrA-5wveA:
15.34
3dqrB-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 VAL A 127
VAL A 324
PHE A 298
GLU A 293
 DTP  A1301 (-4.1A)
None
None
None
 1.25A 3jx2A-5wveA:
undetectable
3jx2B-5wveA:
undetectable		 3jx2A-5wveA:
15.34
3jx2B-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.29A 3jx2A-5wveA:
undetectable
3jx2B-5wveA:
undetectable		 3jx2A-5wveA:
15.34
3jx2B-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.28A 3jx3A-5wveA:
undetectable
3jx3B-5wveA:
undetectable		 3jx3A-5wveA:
15.34
3jx3B-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.28A 3jx4A-5wveA:
undetectable
3jx4B-5wveA:
undetectable		 3jx4A-5wveA:
15.34
3jx4B-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.28A 3jx5A-5wveA:
undetectable
3jx5B-5wveA:
undetectable		 3jx5A-5wveA:
15.34
3jx5B-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.31A 3jx6A-5wveA:
undetectable
3jx6B-5wveA:
undetectable		 3jx6A-5wveA:
15.42
3jx6B-5wveA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 TYR A 435
LEU A 389
LEU A 400
THR A 408
 None
 1.01A 3lm8A-5wveA:
undetectable
3lm8C-5wveA:
undetectable		 3lm8A-5wveA:
10.18
3lm8C-5wveA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A1162
SER A1157
SER A1139
SER A1136
VAL A1205
 None
 1.33A 3m7rA-5wveA:
undetectable		 3m7rA-5wveA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A 127
VAL A 324
PHE A 298
GLU A 293
 DTP  A1301 (-4.1A)
None
None
None
 1.26A 3n61A-5wveA:
undetectable
3n61B-5wveA:
undetectable		 3n61A-5wveA:
15.34
3n61B-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.28A 3n61A-5wveA:
undetectable
3n61B-5wveA:
undetectable		 3n61A-5wveA:
15.34
3n61B-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.26A 3nljA-5wveA:
undetectable
3nljB-5wveA:
undetectable		 3nljA-5wveA:
15.42
3nljB-5wveA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 VAL A 127
VAL A 324
PHE A 298
GLU A 293
 DTP  A1301 (-4.1A)
None
None
None
 1.28A 3nlpA-5wveA:
undetectable
3nlpB-5wveA:
undetectable		 3nlpA-5wveA:
15.34
3nlpB-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.29A 3nlpA-5wveA:
undetectable
3nlpB-5wveA:
undetectable		 3nlpA-5wveA:
15.34
3nlpB-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.28A 3nlqA-5wveA:
undetectable
3nlqB-5wveA:
undetectable		 3nlqA-5wveA:
15.34
3nlqB-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		3 / 3 ARG A 557
LEU A 554
THR A 905
 None
 0.79A 3oxcA-5wveA:
undetectable		 3oxcA-5wveA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 5 VAL A 323
GLU A 339
LYS A 348
PHE A 350
 None
 1.35A 3rv5C-5wveA:
undetectable
3rv5D-5wveA:
undetectable		 3rv5C-5wveA:
5.70
3rv5D-5wveA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 VAL A 127
VAL A 324
PHE A 298
GLU A 293
 DTP  A1301 (-4.1A)
None
None
None
 1.28A 4cx3A-5wveA:
undetectable
4cx3B-5wveA:
undetectable		 4cx3A-5wveA:
15.34
4cx3B-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 VAL A 127
VAL A 324
PHE A 298
GLU A 293
 DTP  A1301 (-4.1A)
None
None
None
 1.27A 4cx4A-5wveA:
undetectable
4cx4B-5wveA:
undetectable		 4cx4A-5wveA:
15.34
4cx4B-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.29A 4cx4A-5wveA:
undetectable
4cx4B-5wveA:
undetectable		 4cx4A-5wveA:
15.34
4cx4B-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		5 / 12 HIS A 614
SER A 632
ILE A 906
TRP A 909
GLY A 887
 None
 1.41A 4foxE-5wveA:
undetectable		 4foxE-5wveA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 6 ASN A 485
TYR A 489
GLU A 525
GLU A 528
 None
 1.42A 4mi4A-5wveA:
undetectable		 4mi4A-5wveA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		5 / 12 ILE A 813
HIS A 827
LEU A 769
ASP A 754
LEU A 757
 None
 1.49A 4pbhA-5wveA:
undetectable		 4pbhA-5wveA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 6 ASN A 485
TYR A 489
GLU A 525
GLU A 528
 None
 1.20A 4r87H-5wveA:
undetectable		 4r87H-5wveA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 6 ASN A 543
GLU A 546
TYR A 577
GLU A 572
 None
 1.36A 4r87H-5wveA:
undetectable		 4r87H-5wveA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wve CASPASE
(Homo
sapiens) 		5 / 12 PHE S  73
CYH S  76
PHE S  35
LEU S  58
LEU S  20
 None
 0.97A 4xumA-5wveS:
undetectable		 4xumA-5wveS:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.27A 5addA-5wveA:
undetectable
5addB-5wveA:
undetectable		 5addA-5wveA:
15.34
5addB-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.26A 5adeA-5wveA:
undetectable
5adeB-5wveA:
undetectable		 5adeA-5wveA:
15.34
5adeB-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
 1.23A 5cymA-5wveA:
1.2		 5cymA-5wveA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
 1.24A 5cyqA-5wveA:
1.3		 5cyqA-5wveA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 VAL A 127
VAL A 324
PHE A 298
GLU A 293
 DTP  A1301 (-4.1A)
None
None
None
 1.26A 5g0pA-5wveA:
undetectable
5g0pB-5wveA:
undetectable		 5g0pA-5wveA:
15.34
5g0pB-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
DTP  A1301 (-4.1A)
None
 1.28A 5g0pA-5wveA:
undetectable
5g0pB-5wveA:
undetectable		 5g0pA-5wveA:
15.34
5g0pB-5wveA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		3 / 3 TRP A1061
ILE A1027
SER A1021
 None
 0.87A 5gqbA-5wveA:
undetectable		 5gqbA-5wveA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 4 THR A1108
LEU A1123
HIS A1121
GLY A1125
 None
 1.18A 5gwyA-5wveA:
undetectable		 5gwyA-5wveA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		3 / 3 VAL A 124
LEU A 306
MET A 301
 None
 0.72A 5ikrA-5wveA:
undetectable		 5ikrA-5wveA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		4 / 6 GLY A1197
THR A1218
TYR A1198
GLY A1217
 None
 0.90A 5k4pA-5wveA:
undetectable		 5k4pA-5wveA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		5 / 12 VAL A 815
ILE A 813
ILE A 781
ASN A 782
VAL A 801
 None
 0.94A 5uvmB-5wveA:
undetectable		 5uvmB-5wveA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 386
ILE A 388
VAL A 395
LEU A 403
LEU A 400
 None
 1.20A 6ajiA-5wveA:
undetectable		 6ajiA-5wveA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
 1.25A 6eliA-5wveA:
undetectable		 6eliA-5wveA:
5.20