SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		4 / 6 VAL A  10
VAL A  52
ILE A  62
ASN A 269
 None
 0.88A 1e06A-5wvmA:
undetectable		 1e06A-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		5 / 10 LEU A 194
LEU A 197
ILE A 163
GLU A 155
LEU A 153
 None
 1.23A 1wopA-5wvmA:
undetectable		 1wopA-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		4 / 7 VAL A  99
ALA A 107
PHE A  94
PRO A  93
 None
 0.95A 2q6oA-5wvmA:
undetectable		 2q6oA-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		5 / 12 ILE A 110
LEU A 264
ILE A  61
VAL A  25
LEU A  22
 None
 1.03A 3a51C-5wvmA:
2.7		 3a51C-5wvmA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		4 / 6 LEU A 149
ALA A 225
PRO A 127
PRO A 128
 None
 1.34A 3gv1A-5wvmA:
undetectable
3gv1B-5wvmA:
undetectable		 3gv1A-5wvmA:
undetectable
3gv1B-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		5 / 12 LEU A 264
ALA A 266
PHE A  63
LEU A  22
THR A 288
 None
 1.31A 3gwuA-5wvmA:
undetectable		 3gwuA-5wvmA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		3 / 3 ASN A 152
ASN A 229
GLU A 216
 None
 0.89A 3kpdC-5wvmA:
undetectable		 3kpdC-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		3 / 3 ASN A 152
ASN A 229
GLU A 216
 None
 0.94A 3kpdB-5wvmA:
undetectable		 3kpdB-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		5 / 11 GLN A  51
ALA A 271
GLY A  56
THR A  55
ALA A  54
 None
 1.07A 3mg0H-5wvmA:
undetectable
3mg0I-5wvmA:
undetectable		 3mg0H-5wvmA:
20.86
3mg0I-5wvmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		4 / 4 ILE A 118
VAL A 248
VAL A 246
ARG A 318
 None
 1.39A 4m6tA-5wvmA:
undetectable		 4m6tA-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		4 / 5 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
None
None
SO4  A 601 ( 4.0A)
 1.00A 4n48A-5wvmA:
undetectable		 4n48A-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		5 / 12 GLN A  51
ALA A 271
GLY A  56
THR A  55
ALA A  54
 None
 1.11A 5l66H-5wvmA:
undetectable
5l66I-5wvmA:
undetectable		 5l66H-5wvmA:
14.04
5l66I-5wvmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		5 / 12 GLN A  51
ALA A 271
GLY A  56
THR A  55
ALA A  54
 None
 1.11A 5l66V-5wvmA:
undetectable
5l66W-5wvmA:
undetectable		 5l66V-5wvmA:
14.04
5l66W-5wvmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		4 / 8 PHE A 494
ARG A 375
ILE A 378
GLY A 376
 None
 0.89A 5nzxA-5wvmA:
undetectable		 5nzxA-5wvmA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		6 / 12 ALA A 344
ALA A 340
GLY A 168
ALA A 190
PHE A 171
VAL A 183
 None
 1.50A 5w4zA-5wvmA:
undetectable		 5w4zA-5wvmA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE
(Escherichia
coli;
Serratia
marcescens) 		4 / 8 LEU A 287
THR A  95
VAL A 263
VAL A 112
 None
 1.04A 6cp4A-5wvmA:
undetectable		 6cp4A-5wvmA:
undetectable