SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 5 GLN C 503
PHE C 499
PHE C 410
GLY C 478
 None
 1.44A 2qmzA-5wvoC:
undetectable
2qmzB-5wvoC:
undetectable		 2qmzA-5wvoC:
22.59
2qmzB-5wvoC:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 8 VAL C 513
TYR C 507
VAL C 561
ILE C 466
 None
 1.06A 4aftD-5wvoC:
undetectable
4aftE-5wvoC:
undetectable		 4aftD-5wvoC:
22.61
4aftE-5wvoC:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 LYS C 406
LYS C 440
PRO C 441
 None
 1.09A 4dv1L-5wvoC:
undetectable		 4dv1L-5wvoC:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 7 GLY C 451
GLY C 452
ASN C 383
GLU C 450
 None
 0.84A 4fgkB-5wvoC:
undetectable		 4fgkB-5wvoC:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 5 GLY C 451
GLY C 452
ASN C 383
GLU C 450
 None
 1.00A 4fglC-5wvoC:
undetectable		 4fglC-5wvoC:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 6 GLY C 451
GLY C 452
ASN C 383
GLU C 450
 None
 0.90A 4fglD-5wvoC:
undetectable		 4fglD-5wvoC:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 5 GLY C 437
SER C 438
ALA C 439
PHE C 410
 None
 1.01A 4m93B-5wvoC:
undetectable
4m93C-5wvoC:
undetectable		 4m93B-5wvoC:
21.13
4m93C-5wvoC:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 7 ALA C 439
ALA C 484
GLU C 485
THR C 481
 None
 0.88A 4r1zB-5wvoC:
undetectable		 4r1zB-5wvoC:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 7 LEU C 426
THR C 424
ILE C 498
LEU C 501
 None
 1.03A 5fxtA-5wvoC:
undetectable		 5fxtA-5wvoC:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 GLY C 471
GLY C 468
LYS C 510
TYR C 507
PRO C 537
 None
 1.10A 6ce2B-5wvoC:
undetectable		 6ce2B-5wvoC:
15.20