SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wvr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		4 / 6 GLY A1237
THR A 930
THR A1156
ILE A1239
 None
 0.87A 1gtnD-5wvrA:
undetectable
1gtnE-5wvrA:
undetectable		 1gtnD-5wvrA:
11.11
1gtnE-5wvrA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		4 / 7 GLY A1237
THR A 930
THR A1156
ILE A1239
 None
 0.94A 1gtnF-5wvrA:
undetectable
1gtnG-5wvrA:
undetectable		 1gtnF-5wvrA:
11.11
1gtnG-5wvrA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		4 / 6 VAL A1060
VAL A1079
ILE A1041
ARG A 900
 None
 0.88A 1iepA-5wvrA:
undetectable		 1iepA-5wvrA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		3 / 3 PHE A1205
PHE A 943
PHE A 942
 None
 0.82A 2od9A-5wvrA:
undetectable		 2od9A-5wvrA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		3 / 3 PHE A1205
PHE A 943
PHE A 942
 None
 0.82A 2qqgA-5wvrA:
undetectable		 2qqgA-5wvrA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		4 / 8 ARG A1165
GLN A1164
ARG A 832
TYR A 933
 None
 1.49A 2vxaB-5wvrA:
undetectable
2vxaG-5wvrA:
undetectable
2vxaH-5wvrA:
undetectable		 2vxaB-5wvrA:
9.70
2vxaG-5wvrA:
9.70
2vxaH-5wvrA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		5 / 9 VAL A 909
ILE A1041
GLY A1058
ILE A1070
ILE A 906
 None
 1.11A 3ekqB-5wvrA:
undetectable		 3ekqB-5wvrA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		4 / 7 VAL A1060
VAL A1079
ILE A1041
ARG A 900
 None
 0.90A 3mssB-5wvrA:
undetectable		 3mssB-5wvrA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		5 / 12 ASP A1037
ASN A1032
GLY A 998
SER A 996
ASN A 997
 None
 1.35A 4djeB-5wvrA:
undetectable		 4djeB-5wvrA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		5 / 12 LEU A1016
LEU A1017
GLY A1018
VAL A1012
ARG A1046
 SO4  A1302 (-4.3A)
SO4  A1302 (-3.6A)
None
None
SO4  A1302 ( 4.3A)
 1.28A 4olmA-5wvrA:
undetectable		 4olmA-5wvrA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		3 / 3 ASP A1116
LYS A1083
LEU A 899
 None
 1.06A 4ptjA-5wvrA:
undetectable		 4ptjA-5wvrA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		4 / 7 PRO A1154
TRP A1204
TRP A1225
PHE A1220
 None
 1.49A 4v32C-5wvrA:
undetectable		 4v32C-5wvrA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		4 / 5 ARG A1203
GLY A1237
GLU A1236
ARG A1193
 None
 0.94A 5cdqA-5wvrA:
undetectable
5cdqB-5wvrA:
undetectable
5cdqC-5wvrA:
undetectable		 5cdqA-5wvrA:
21.43
5cdqB-5wvrA:
16.47
5cdqC-5wvrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		4 / 5 ARG A1203
GLY A1237
GLU A1236
ARG A1193
 None
 1.09A 5cdqR-5wvrA:
undetectable
5cdqS-5wvrA:
undetectable
5cdqT-5wvrA:
undetectable		 5cdqR-5wvrA:
21.43
5cdqS-5wvrA:
16.47
5cdqT-5wvrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		5 / 9 VAL A 909
ILE A1041
GLY A1058
ILE A1070
ILE A 906
 None
 1.00A 5kqxB-5wvrA:
undetectable		 5kqxB-5wvrA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		4 / 5 ARG A 861
MET A 862
THR A 863
LEU A 864
 None
None
None
CLR  A1301 (-4.2A)
 1.28A 5x19J-5wvrA:
undetectable		 5x19J-5wvrA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		4 / 5 ARG A 861
MET A 862
THR A 863
LEU A 864
 None
None
None
CLR  A1301 (-4.2A)
 1.25A 5x1bJ-5wvrA:
undetectable		 5x1bJ-5wvrA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		5 / 12 LEU A 835
GLU A1130
GLU A 870
ARG A1128
GLU A 880
 None
 1.20A 5xipD-5wvrA:
undetectable		 5xipD-5wvrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		5 / 12 GLY A1117
TYR A 903
LEU A 902
ILE A1070
MET A1093
 None
 1.28A 5y2tA-5wvrA:
undetectable		 5y2tA-5wvrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		5 / 11 ASP A1238
PHE A1240
LEU A 926
LEU A1160
PRO A1162
 None
 1.49A 6fgcA-5wvrA:
undetectable		 6fgcA-5wvrA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5wvr KLLA0C04147P
(Kluyveromyces
lactis) 		4 / 5 ARG A 861
MET A 862
THR A 863
LEU A 864
 None
None
None
CLR  A1301 (-4.2A)
 1.41A 6nknJ-5wvrA:
undetectable		 6nknJ-5wvrA:
8.76