SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wvx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5wvx TRYPSIN/CHYMOTRYPSIN
INHIBITOR
(Alocasia
macrorrhizos) 		5 / 12 LEU A  12
GLU A  70
GLY A 122
CYH A 138
ALA A 121
 None
 1.16A 2br4B-5wvxA:
undetectable		 2br4B-5wvxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wvx TRYPSIN/CHYMOTRYPSIN
INHIBITOR
(Alocasia
macrorrhizos) 		3 / 3 ALA A  20
TYR A  19
PRO A  79
 None
 0.50A 4zdyA-5wvxA:
undetectable		 4zdyA-5wvxA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5wvx TRYPSIN/CHYMOTRYPSIN
INHIBITOR
(Alocasia
macrorrhizos) 		4 / 5 PRO A 145
VAL A 135
GLY A  53
VAL A  43
 None
 1.03A 6ak3B-5wvxA:
undetectable		 6ak3B-5wvxA:
20.93