SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wwl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1

(Schizosaccharomy
ces
pombe)
4 / 7 TYR N 110
MET M 109
ASP M 110
ASP M 106
None
1.46A 1t03A-5wwlN:
undetectable
1t03A-5wwlN:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)
5wwl KINETOCHORE PROTEIN
NNF1

(Schizosaccharomy
ces
pombe)
3 / 3 LEU N 109
HIS N 112
LYS N 113
None
1.12A 1y7iA-5wwlN:
undetectable
1y7iA-5wwlN:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))
5wwl CENTROMERE PROTEIN
MIS12

(Schizosaccharomy
ces
pombe)
4 / 4 VAL M 186
ARG M 201
ILE M 151
THR M 192
None
1.43A 3cl9A-5wwlM:
undetectable
3cl9A-5wwlM:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1

(Schizosaccharomy
ces
pombe)
4 / 5 ASP M  98
VAL M  97
GLY M  94
ASP N  82
None
1.38A 3w9tA-5wwlM:
undetectable
3w9tA-5wwlM:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1

(Schizosaccharomy
ces
pombe)
4 / 5 ASP M  98
VAL M  97
GLY M  94
ASP N  82
None
1.37A 3w9tB-5wwlM:
undetectable
3w9tB-5wwlM:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1

(Schizosaccharomy
ces
pombe)
4 / 5 ASP M  98
VAL M  97
GLY M  94
ASP N  82
None
1.37A 3w9tF-5wwlM:
undetectable
3w9tF-5wwlM:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
5 / 9 THR N  19
LEU N  12
LEU N  16
THR M  21
VAL M  64
None
1.49A 4c9kB-5wwlN:
undetectable
4c9kB-5wwlN:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1

(Schizosaccharomy
ces
pombe)
4 / 4 LEU M 154
LEU M 148
GLN M 175
GLU N 160
None
1.27A 4i41A-5wwlM:
undetectable
4i41A-5wwlM:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)
5wwl CENTROMERE PROTEIN
MIS12

(Schizosaccharomy
ces
pombe)
4 / 7 LEU M 154
SER M 213
THR M 164
PHE M 171
None
1.04A 4wnvD-5wwlM:
undetectable
4wnvD-5wwlM:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)
5wwl CENTROMERE PROTEIN
MIS12

(Schizosaccharomy
ces
pombe)
5 / 11 VAL M  64
ASP M  65
TYR M  68
GLY M  28
PHE M  60
None
1.21A 4xp4A-5wwlM:
undetectable
4xp4A-5wwlM:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
4 / 5 PHE N  32
LEU N  48
GLY M  31
ILE M  49
None
0.97A 5ik1A-5wwlN:
undetectable
5ik1A-5wwlN:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1

(Schizosaccharomy
ces
pombe)
4 / 4 VAL M 121
LEU M 120
LEU N 124
ASP N 128
None
1.03A 5xv7A-5wwlM:
undetectable
5xv7A-5wwlM:
16.74