SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 417
ARG A 411
PHE A 364
 None
 1.08A 1zeaH-5wwoA:
undetectable
1zeaL-5wwoA:
undetectable		 1zeaH-5wwoA:
20.29
1zeaL-5wwoA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 420
PHE A 421
ALA A 425
LEU A 460
 None
 0.90A 2bxmA-5wwoA:
2.6		 2bxmA-5wwoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 420
TYR A 393
ILE A 416
ILE A 372
 None
 1.08A 2dcfA-5wwoA:
undetectable		 2dcfA-5wwoA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 420
TYR A 393
ILE A 416
ILE A 372
 None
 1.05A 2zm7A-5wwoA:
undetectable		 2zm7A-5wwoA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 420
TYR A 393
ILE A 416
ILE A 372
 None
 1.06A 2zmaA-5wwoA:
undetectable		 2zmaA-5wwoA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 237
PHE A 278
ALA A 262
 None
 0.63A 3itaD-5wwoA:
undetectable		 3itaD-5wwoA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 307
LEU A 283
ILE A 337
GLY A 339
ALA A 338
 None
 1.09A 3kk6A-5wwoA:
undetectable		 3kk6A-5wwoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 213
ILE A 211
GLY A 218
ILE A 220
VAL A 235
 None
 1.07A 3ogpA-5wwoA:
undetectable		 3ogpA-5wwoA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 311
LEU A 283
VAL A 341
GLY A 339
ALA A 338
 None
 1.25A 3pghB-5wwoA:
undetectable		 3pghB-5wwoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 419
VAL A 415
HIS A 449
 None
 1.10A 3tj7A-5wwoA:
undetectable		 3tj7A-5wwoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 LYS A 264
LEU A 265
GLU A 261
LEU A 229
 None
 1.06A 4k4yA-5wwoA:
2.1		 4k4yA-5wwoA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 4 LYS A 264
LEU A 265
GLU A 261
LEU A 229
 None
 1.07A 4k4yE-5wwoA:
undetectable		 4k4yE-5wwoA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 LYS A 264
LEU A 265
GLU A 261
LEU A 229
 None
 1.10A 4k4yI-5wwoA:
1.9		 4k4yI-5wwoA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 352
TYR A 380
PRO A 314
 None
 0.92A 4k8cA-5wwoA:
undetectable		 4k8cA-5wwoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 352
TYR A 380
PRO A 314
 None
 0.92A 4kahA-5wwoA:
undetectable		 4kahA-5wwoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 352
TYR A 380
PRO A 314
 None
 0.90A 4kahB-5wwoA:
undetectable		 4kahB-5wwoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 352
TYR A 380
PRO A 314
 None
 0.94A 4kanA-5wwoA:
undetectable		 4kanA-5wwoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 352
TYR A 380
PRO A 314
 None
 0.91A 4kanB-5wwoA:
undetectable		 4kanB-5wwoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 352
TYR A 380
PRO A 314
 None
 0.88A 4kbeA-5wwoA:
undetectable		 4kbeA-5wwoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 352
TYR A 380
PRO A 314
 None
 0.86A 4kbeB-5wwoA:
undetectable		 4kbeB-5wwoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 352
TYR A 380
PRO A 314
 None
 0.93A 4lbgA-5wwoA:
undetectable		 4lbgA-5wwoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 352
TYR A 380
PRO A 314
 None
 0.94A 4lbgB-5wwoA:
undetectable		 4lbgB-5wwoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 459
PHE A 424
LYS A 429
TYR A 428
 None
 1.36A 4uciB-5wwoA:
undetectable		 4uciB-5wwoA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
PROTEIN LTV1
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 320
TYR A 358
TYR C 371
GLY C 367
 None
 0.77A 5ayfA-5wwoA:
undetectable		 5ayfA-5wwoA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 285
PHE A 321
ALA A 338
THR A 368
LEU A 359
 None
 1.47A 6efnA-5wwoA:
undetectable		 6efnA-5wwoA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 5wwo ESSENTIAL NUCLEAR
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 276
GLY A 320
PHE A 321
VAL A 326
 None
 1.04A 6hu9S-5wwoA:
undetectable
6hu9q-5wwoA:
undetectable		 6hu9S-5wwoA:
13.08
6hu9q-5wwoA:
18.34