SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wwp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 4 GLY B  87
ASP B  32
GLY B  99
THR B  12
 None
None
ZN  B 601 ( 4.2A)
None
 1.06A 1hxbB-5wwpB:
undetectable		 1hxbB-5wwpB:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 6 ILE B 512
ARG B 567
PRO B 445
SER B 468
 None
SO4  B 604 ( 4.9A)
None
None
 1.24A 2qd3B-5wwpB:
2.3		 2qd3B-5wwpB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 VAL B 280
PHE B 269
SER B 264
PHE B 291
HIS B 290
 None
 1.24A 2vdyA-5wwpB:
undetectable		 2vdyA-5wwpB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 PHE B 133
ALA B 135
LEU B 109
ARG B 108
LEU B 130
 None
 1.07A 3nrrA-5wwpB:
undetectable		 3nrrA-5wwpB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 11 PHE B 499
GLY B 571
TYR B 543
GLU B 447
ILE B 448
 None
 1.30A 3owxA-5wwpB:
undetectable
3owxB-5wwpB:
undetectable		 3owxA-5wwpB:
17.83
3owxB-5wwpB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		3 / 3 THR B 366
SER B 367
ARG B 303
 None
 0.76A 3phnA-5wwpB:
undetectable		 3phnA-5wwpB:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 TYR B 457
VAL B 563
VAL B 533
ILE B 565
 None
 1.16A 4aftD-5wwpB:
undetectable
4aftE-5wwpB:
undetectable		 4aftD-5wwpB:
17.12
4aftE-5wwpB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 LEU B 438
VAL B 372
ASP B 374
VAL B 397
 None
 0.99A 4cp4A-5wwpB:
undetectable		 4cp4A-5wwpB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 5 PHE B 225
ILE B 154
GLY B 222
THR B 220
 None
 1.00A 4ejjC-5wwpB:
undetectable		 4ejjC-5wwpB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 LEU B 438
VAL B 372
ASP B 374
VAL B 397
 None
 0.96A 4l4bA-5wwpB:
undetectable		 4l4bA-5wwpB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 PHE B 587
ILE B 572
PHE B 561
ASN B 562
 None
 1.42A 4o7gA-5wwpB:
undetectable
4o7gB-5wwpB:
undetectable		 4o7gA-5wwpB:
18.02
4o7gB-5wwpB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 PHE B 291
SER B 264
VAL B 280
PHE B 437
 None
 0.93A 4wnvD-5wwpB:
undetectable		 4wnvD-5wwpB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		3 / 3 ARG B 443
PRO B 284
ASN B 562
 SO4  B 604 (-3.4A)
SO4  B 604 (-4.5A)
None
 0.99A 5jwaA-5wwpB:
undetectable
5jwaH-5wwpB:
undetectable		 5jwaA-5wwpB:
21.68
5jwaH-5wwpB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		3 / 3 THR B 566
PRO B 284
ASP B 401
 None
SO4  B 604 (-4.5A)
None
 0.84A 5l8dB-5wwpB:
undetectable		 5l8dB-5wwpB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		3 / 3 SER B 275
TYR B 274
TYR B 246
 None
 0.77A 5lakA-5wwpB:
undetectable
5lakI-5wwpB:
undetectable		 5lakA-5wwpB:
19.87
5lakI-5wwpB:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		3 / 3 SER B 275
TYR B 274
TYR B 246
 None
 0.81A 5lakC-5wwpB:
undetectable
5lakJ-5wwpB:
undetectable		 5lakC-5wwpB:
19.87
5lakJ-5wwpB:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		3 / 3 THR B 566
PRO B 284
ASP B 401
 None
SO4  B 604 (-4.5A)
None
 0.84A 5mwuB-5wwpB:
undetectable		 5mwuB-5wwpB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 ILE B 565
PHE B 561
LYS B 473
SER B 578
 None
 1.43A 5nr3A-5wwpB:
undetectable		 5nr3A-5wwpB:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 6 TYR B  70
LEU B  88
PHE B  90
LEU B  14
 None
 1.09A 5tl8A-5wwpB:
undetectable		 5tl8A-5wwpB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 THR B  37
HIS B  33
PHE B 106
THR B 137
 None
ZN  B 602 (-3.0A)
None
None
 1.04A 5u6mA-5wwpB:
undetectable		 5u6mA-5wwpB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 THR B  37
HIS B  33
PHE B 106
THR B 137
 None
ZN  B 602 (-3.0A)
None
None
 1.05A 5u6mB-5wwpB:
undetectable		 5u6mB-5wwpB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 11 ALA B 368
VAL B 425
ILE B 240
ASN B 388
GLN B 243
 None
 1.32A 5y80A-5wwpB:
undetectable		 5y80A-5wwpB:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 LEU B 438
VAL B 372
ASP B 374
VAL B 397
 None
 0.97A 6cp4A-5wwpB:
undetectable		 6cp4A-5wwpB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5wwp ORF1AB
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 LYS B 276
GLY B 273
GLY B 251
LEU B 252
 None
 0.84A 6mdqA-5wwpB:
undetectable		 6mdqA-5wwpB:
7.77