SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 8 LEU A 225
HIS A 228
ASP A  94
LEU A  92
 None
 0.93A 1e7cA-5wwtA:
undetectable		 1e7cA-5wwtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		3 / 3 ASP A 266
ASP A 293
ASP A 323
 None
None
C  C  72 ( 2.8A)
 0.57A 1eizA-5wwtA:
10.5		 1eizA-5wwtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		3 / 3 ASP A 266
ASP A 293
ASP A 323
 None
None
C  C  72 ( 2.8A)
 0.63A 1ej0A-5wwtA:
10.6		 1ej0A-5wwtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		3 / 4 LYS A  32
ALA A  35
MET A  22
 None
 0.95A 1hk3A-5wwtA:
undetectable		 1hk3A-5wwtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 6 ALA A 411
LEU A 388
GLU A 381
LEU A 421
 None
 0.82A 1mt1D-5wwtA:
undetectable
1mt1E-5wwtA:
undetectable		 1mt1D-5wwtA:
13.92
1mt1E-5wwtA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		5 / 11 ARG A 423
THR A 374
GLU A 382
GLU A 381
SER A 327
 None
 1.50A 1odiE-5wwtA:
undetectable		 1odiE-5wwtA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		8 / 12 CYH A 242
ALA A 244
GLY A 246
GLY A 247
LYS A 248
ASP A 293
GLY A 294
PRO A 325
 None
None
None
None
C  C  72 ( 3.1A)
None
None
None
 0.58A 1sqfA-5wwtA:
31.2		 1sqfA-5wwtA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		3 / 3 PRO A 245
ASP A 266
ASP A 323
 C  C  72 ( 4.7A)
None
C  C  72 ( 2.8A)
 0.40A 1sqfA-5wwtA:
17.4		 1sqfA-5wwtA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		5 / 12 CYH A 242
PRO A 245
GLY A 246
LYS A 248
ASP A 293
 None
C  C  72 ( 4.7A)
None
C  C  72 ( 3.1A)
None
 0.26A 2b9eA-5wwtA:
15.4		 2b9eA-5wwtA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 4 PRO A 245
ASP A 266
ASP A 293
ASP A 240
 C  C  72 ( 4.7A)
None
None
None
 1.30A 2nyuA-5wwtA:
10.6		 2nyuA-5wwtA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 4 PRO A 245
ASP A 266
ASP A 293
ASP A 323
 C  C  72 ( 4.7A)
None
None
C  C  72 ( 2.8A)
 0.45A 2nyuA-5wwtA:
10.6		 2nyuA-5wwtA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 5 PRO A 245
ASP A 266
ASP A 293
ASP A 323
 C  C  72 ( 4.7A)
None
None
C  C  72 ( 2.8A)
 0.47A 2nyuB-5wwtA:
10.8		 2nyuB-5wwtA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 8 ASP A 433
SER A   2
HIS A  45
HIS A  48
 None
 1.33A 2v0gA-5wwtA:
undetectable		 2v0gA-5wwtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 4 VAL A 429
ASP A 433
LEU A 439
ARG A 449
 None
 1.39A 2ziaA-5wwtA:
undetectable		 2ziaA-5wwtA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		5 / 9 ALA A 118
ASN A 334
LEU A   9
VAL A  13
ILE A   7
 None
 1.42A 3claA-5wwtA:
undetectable		 3claA-5wwtA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		5 / 12 LEU A 225
PHE A 458
LEU A 321
ASP A 240
ASP A 323
 None
C  C  72 ( 4.4A)
None
None
C  C  72 ( 2.8A)
 1.19A 3gwuA-5wwtA:
undetectable		 3gwuA-5wwtA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 6 GLY A 117
MET A 335
ILE A 115
VAL A 116
 A  C  76 ( 4.5A)
None
None
None
 1.12A 3kvvA-5wwtA:
undetectable		 3kvvA-5wwtA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 6 GLY A 117
MET A 335
ILE A 115
VAL A 116
 A  C  76 ( 4.5A)
None
None
None
 1.13A 3kvvB-5wwtA:
undetectable		 3kvvB-5wwtA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 6 GLY A 117
MET A 335
ILE A 115
VAL A 116
 A  C  76 ( 4.5A)
None
None
None
 1.09A 3kvvC-5wwtA:
undetectable		 3kvvC-5wwtA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 6 GLY A 117
MET A 335
ILE A 115
VAL A 116
 A  C  76 ( 4.5A)
None
None
None
 1.14A 3kvvF-5wwtA:
undetectable		 3kvvF-5wwtA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		7 / 12 PRO A 245
GLY A 246
GLY A 247
LYS A 248
ASP A 323
PRO A 325
LEU A 354
 C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
C  C  72 ( 2.8A)
None
None
 0.50A 3m6vA-5wwtA:
33.4		 3m6vA-5wwtA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		5 / 12 GLY A 247
LYS A 248
ASP A 323
PRO A 325
LEU A 354
 None
C  C  72 ( 3.1A)
C  C  72 ( 2.8A)
None
None
 1.00A 3m6vB-5wwtA:
33.4		 3m6vB-5wwtA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		7 / 12 PRO A 245
GLY A 246
GLY A 247
LYS A 248
ASP A 323
PRO A 325
LEU A 354
 C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
C  C  72 ( 2.8A)
None
None
 0.51A 3m6vB-5wwtA:
33.4		 3m6vB-5wwtA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		6 / 12 PRO A 245
GLY A 246
GLY A 247
LYS A 248
PRO A 325
LEU A 354
 C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
None
None
 0.46A 3m6wA-5wwtA:
33.6		 3m6wA-5wwtA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		5 / 9 PHE A 290
VAL A 272
ILE A 263
ALA A 264
ALA A 279
 None
 1.27A 3mdtA-5wwtA:
undetectable		 3mdtA-5wwtA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		5 / 9 HIS A 251
SER A 227
GLN A 219
VAL A 262
GLY A 247
 None
 1.44A 3tehA-5wwtA:
undetectable		 3tehA-5wwtA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 4 LEU A 179
GLY A 195
MET A 142
PHE A 185
 None
 1.34A 3vaqB-5wwtA:
4.5		 3vaqB-5wwtA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		6 / 12 PRO A 245
GLY A 246
GLY A 247
ASP A 266
ASP A 293
ASP A 323
 C  C  72 ( 4.7A)
None
None
None
None
C  C  72 ( 2.8A)
 0.72A 4b17A-5wwtA:
9.6		 4b17A-5wwtA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		6 / 12 CYH A 242
GLY A 247
LYS A 248
ASP A 323
PRO A 325
LEU A 354
 None
None
C  C  72 ( 3.1A)
C  C  72 ( 2.8A)
None
None
 1.14A 4fp9A-5wwtA:
26.8		 4fp9A-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		9 / 12 CYH A 242
PRO A 245
GLY A 246
GLY A 247
LYS A 248
GLY A 294
ASP A 323
PRO A 325
LEU A 354
 None
C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
None
C  C  72 ( 2.8A)
None
None
 0.48A 4fp9A-5wwtA:
26.8		 4fp9A-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		9 / 12 CYH A 242
PRO A 245
GLY A 246
GLY A 247
LYS A 248
GLY A 294
ASP A 323
PRO A 325
LEU A 354
 None
C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
None
C  C  72 ( 2.8A)
None
None
 0.48A 4fp9C-5wwtA:
26.8		 4fp9C-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		9 / 12 CYH A 242
PRO A 245
GLY A 246
GLY A 247
LYS A 248
ASP A 293
GLY A 294
PRO A 325
LEU A 354
 None
C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
None
None
None
None
 0.58A 4fp9D-5wwtA:
26.5		 4fp9D-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		6 / 12 CYH A 242
GLY A 247
LYS A 248
ASP A 323
PRO A 325
LEU A 354
 None
None
C  C  72 ( 3.1A)
C  C  72 ( 2.8A)
None
None
 1.12A 4fp9F-5wwtA:
26.7		 4fp9F-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		9 / 12 CYH A 242
PRO A 245
GLY A 246
GLY A 247
LYS A 248
GLY A 294
ASP A 323
PRO A 325
LEU A 354
 None
C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
None
C  C  72 ( 2.8A)
None
None
 0.46A 4fp9F-5wwtA:
26.7		 4fp9F-5wwtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		9 / 12 CYH A 242
PRO A 245
GLY A 246
GLY A 247
LYS A 248
ASP A 293
GLY A 294
PRO A 325
LEU A 354
 None
C  C  72 ( 4.7A)
None
None
C  C  72 ( 3.1A)
None
None
None
None
 0.56A 4fzvA-5wwtA:
26.7		 4fzvA-5wwtA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 5 PRO A 245
GLY A 247
ASP A 293
ASP A 323
 C  C  72 ( 4.7A)
None
None
C  C  72 ( 2.8A)
 0.56A 4n48B-5wwtA:
9.7		 4n48B-5wwtA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		5 / 9 PHE A 185
ILE A 148
VAL A 150
GLY A 195
VAL A 116
 None
 0.93A 4r20B-5wwtA:
undetectable		 4r20B-5wwtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		3 / 3 VAL A 136
ALA A 162
PHE A 185
 None
G  C  24 ( 3.9A)
None
 0.89A 4z4iA-5wwtA:
undetectable		 4z4iA-5wwtA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		3 / 3 VAL A 136
ALA A 162
PHE A 185
 None
G  C  24 ( 3.9A)
None
 0.88A 5js1A-5wwtA:
undetectable		 5js1A-5wwtA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		4 / 5 SER A 346
ALA A 345
GLN A 383
THR A 376
 G  C   4 ( 3.6A)
None
None
None
 1.24A 5n0tA-5wwtA:
undetectable		 5n0tA-5wwtA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		6 / 12 ALA A 244
PRO A 245
ASP A 266
LYS A 271
ASP A 293
LEU A 350
 None
C  C  72 ( 4.7A)
None
C  C  70 ( 3.9A)
None
G  C   3 ( 3.9A)
 1.12A 5wwsA-5wwtA:
65.1		 5wwsA-5wwtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		12 / 12 CYH A 242
ALA A 244
PRO A 245
GLY A 247
ASP A 266
LYS A 267
LYS A 271
ASP A 293
GLY A 294
ASP A 323
LEU A 350
LEU A 354
 None
None
C  C  72 ( 4.7A)
None
None
G  C   3 ( 3.5A)
C  C  70 ( 3.9A)
None
None
C  C  72 ( 2.8A)
G  C   3 ( 3.9A)
None
 0.16A 5wwsA-5wwtA:
65.1		 5wwsA-5wwtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		12 / 12 CYH A 242
ALA A 244
PRO A 245
GLY A 247
LYS A 248
ASP A 266
LYS A 267
ILE A 268
LYS A 271
ASP A 293
GLY A 294
ASP A 323
 None
None
C  C  72 ( 4.7A)
None
C  C  72 ( 3.1A)
None
G  C   3 ( 3.5A)
C  C  69 ( 3.9A)
C  C  70 ( 3.9A)
None
None
C  C  72 ( 2.8A)
 0.18A 5wwsB-5wwtA:
65.0		 5wwsB-5wwtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		5 / 12 PRO A 245
GLY A 247
LYS A 248
ASP A 293
PRO A 325
 C  C  72 ( 4.7A)
None
C  C  72 ( 3.1A)
None
None
 0.46A 5zvgA-5wwtA:
42.5		 5zvgA-5wwtA:
33.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		5 / 12 PRO A 245
GLY A 247
LYS A 248
LYS A 267
PRO A 325
 C  C  72 ( 4.7A)
None
C  C  72 ( 3.1A)
G  C   3 ( 3.5A)
None
 0.74A 5zvgA-5wwtA:
42.5		 5zvgA-5wwtA:
33.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		5 / 12 PRO A 245
GLY A 247
LYS A 248
ASP A 293
PRO A 325
 C  C  72 ( 4.7A)
None
C  C  72 ( 3.1A)
None
None
 0.44A 5zvgB-5wwtA:
42.6		 5zvgB-5wwtA:
33.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens) 		5 / 12 PRO A 245
GLY A 247
LYS A 248
LYS A 267
PRO A 325
 C  C  72 ( 4.7A)
None
C  C  72 ( 3.1A)
G  C   3 ( 3.5A)
None
 0.76A 5zvgB-5wwtA:
42.6		 5zvgB-5wwtA:
33.26