SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wx1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		5 / 12 GLY A 164
SER A 172
GLY A 177
ASP A 106
VAL A  67
 None
 1.26A 1ffyA-5wx1A:
undetectable		 1ffyA-5wx1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 5 ALA A 450
TYR A 427
ALA A 453
TYR A 429
 None
 1.02A 1xl6A-5wx1A:
undetectable
1xl6B-5wx1A:
undetectable		 1xl6A-5wx1A:
17.30
1xl6B-5wx1A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		5 / 12 TYR A 297
LEU A 253
LEU A 308
LEU A 559
TYR A 560
 None
 1.42A 1zgyA-5wx1A:
undetectable		 1zgyA-5wx1A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		5 / 12 GLY A 231
GLY A 229
GLU A 235
ILE A 254
VAL A 263
 None
 0.82A 2oxtB-5wx1A:
undetectable		 2oxtB-5wx1A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		5 / 9 PHE A 118
ILE A -27
GLY A 173
PHE A 168
THR A -19
 None
 1.13A 2tsrD-5wx1A:
undetectable		 2tsrD-5wx1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 4 ALA A 450
TYR A 427
ALA A 453
TYR A 429
 None
 0.95A 2wlkA-5wx1A:
undetectable
2wlkB-5wx1A:
undetectable		 2wlkA-5wx1A:
17.30
2wlkB-5wx1A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 7 LEU A 165
TRP A 162
ALA A 122
GLY A 130
 None
 0.98A 2wq5A-5wx1A:
undetectable		 2wq5A-5wx1A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 7 PHE A 142
GLY A 139
LYS A 137
TYR A 555
 None
 1.26A 3aruA-5wx1A:
undetectable		 3aruA-5wx1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		5 / 12 ASN A 604
ALA A 673
VAL A 671
GLY A 666
VAL A 655
 None
 1.13A 3c6gB-5wx1A:
undetectable		 3c6gB-5wx1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 7 GLY A 164
VAL A  67
ILE A 167
VAL A 117
 None
 0.72A 3fi0E-5wx1A:
undetectable		 3fi0E-5wx1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 8 GLY A 164
VAL A  67
ILE A 167
VAL A 117
 None
 0.66A 3fi0G-5wx1A:
undetectable		 3fi0G-5wx1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 8 GLY A 164
VAL A  67
ILE A 167
VAL A 117
 None
 0.67A 3fi0Q-5wx1A:
undetectable		 3fi0Q-5wx1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		5 / 12 ALA A 535
ILE A 599
LEU A 570
ILE A 486
LEU A 479
 None
 1.14A 3k2hB-5wx1A:
undetectable		 3k2hB-5wx1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 5 SER A 172
GLY A 177
GLU A 100
GLU A  98
 None
 1.28A 3raeB-5wx1A:
undetectable
3raeD-5wx1A:
3.3		 3raeB-5wx1A:
21.09
3raeD-5wx1A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		5 / 12 HIS A  69
ASP A  97
LYS A 160
GLY A 161
LYS A 180
 None
 1.21A 3sueB-5wx1A:
15.4		 3sueB-5wx1A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		3 / 3 LYS A  22
ARG A  31
LEU A  77
 None
 1.24A 3v4tE-5wx1A:
undetectable		 3v4tE-5wx1A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		3 / 3 ARG A 476
LYS A 491
ARG A 478
 None
 1.31A 3w1wA-5wx1A:
2.5
3w1wB-5wx1A:
2.4		 3w1wA-5wx1A:
20.03
3w1wB-5wx1A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		3 / 3 ARG A 478
ARG A 476
LYS A 491
 None
 1.35A 3w1wA-5wx1A:
2.5
3w1wB-5wx1A:
2.3		 3w1wA-5wx1A:
20.03
3w1wB-5wx1A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		5 / 10 VAL A -33
LEU A  76
VAL A  78
THR A  59
VAL A  87
 None
 0.95A 4e3hA-5wx1A:
undetectable		 4e3hA-5wx1A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		5 / 12 PRO A 643
GLU A 607
ALA A 673
GLY A 674
LEU A 677
 None
 1.48A 4oadA-5wx1A:
undetectable		 4oadA-5wx1A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 6 GLU A 651
TYR A 646
THR A 488
TYR A 629
 None
 1.46A 4qwpA-5wx1A:
undetectable		 4qwpA-5wx1A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 5 GLU A 651
TYR A 646
THR A 488
TYR A 629
 None
 1.45A 4qwpB-5wx1A:
undetectable		 4qwpB-5wx1A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		5 / 11 ALA A 415
VAL A 449
LEU A 418
LEU A 385
VAL A 403
 None
 1.26A 5eb5A-5wx1A:
undetectable		 5eb5A-5wx1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHQ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		5 / 12 GLU A 562
TYR A 555
MET A 566
ASN A 574
ASP A 527
 None
 1.34A 5fhqA-5wx1A:
3.5		 5fhqA-5wx1A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 4 GLU A 562
THR A 568
THR A 190
LEU A 683
 None
 1.32A 5v96A-5wx1A:
2.7		 5v96A-5wx1A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 4 GLU A 562
THR A 568
THR A 190
LEU A 683
 None
 1.33A 5v96B-5wx1A:
2.6		 5v96B-5wx1A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 4 GLU A 562
THR A 568
THR A 190
LEU A 683
 None
 1.32A 5v96C-5wx1A:
2.6		 5v96C-5wx1A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 4 GLU A 562
THR A 568
THR A 190
LEU A 683
 None
 1.31A 5v96D-5wx1A:
2.7		 5v96D-5wx1A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 6 ARG A 249
PHE A 317
ILE A 292
THR A 293
 None
 0.96A 5vceA-5wx1A:
undetectable		 5vceA-5wx1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 6 TYR A -14
TRP A 162
LEU A 683
LEU A 192
 None
 1.11A 5xooA-5wx1A:
undetectable		 5xooA-5wx1A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5wx1 SERINE PROTEASE NS3
(Pestivirus
C) 		4 / 6 ARG A 503
ALA A 388
THR A 414
ALA A 450
 None
 1.01A 6ma6A-5wx1A:
undetectable		 6ma6A-5wx1A:
8.63