SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wx3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 GLY A 368
PHE A 367
SER A 335
ILE A 248
LEU A 261
 None
None
None
COA  A 401 ( 4.9A)
COA  A 401 (-3.8A)
 1.30A 1lhuA-5wx3A:
undetectable		 1lhuA-5wx3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		4 / 8 SER A 321
THR A 375
PHE A 367
MET A 307
 None
 1.09A 1lhvA-5wx3A:
undetectable		 1lhvA-5wx3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		4 / 6 GLU A 186
ALA A 102
PRO A 334
ALA A 214
 None
 1.16A 2zgwB-5wx3A:
undetectable		 2zgwB-5wx3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 ALA A 213
GLY A 212
LEU A 337
SER A 335
MET A 331
 None
 1.30A 3bxoA-5wx3A:
undetectable		 3bxoA-5wx3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 ALA A 213
GLY A 212
LEU A 337
SER A 335
MET A 331
 None
 1.28A 3bxoB-5wx3A:
undetectable		 3bxoB-5wx3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		4 / 8 VAL A 336
VAL A 363
PHE A 365
HIS A 297
 None
 1.08A 3fhxB-5wx3A:
undetectable		 3fhxB-5wx3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		4 / 4 GLY A 300
VAL A 303
GLY A 368
THR A 372
 COA  A 401 ( 3.7A)
None
None
None
 0.86A 3ib2A-5wx3A:
undetectable		 3ib2A-5wx3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		4 / 6 ASN A  80
TYR A 260
TYR A 199
LEU A 202
 None
SO4  A 402 (-4.6A)
None
None
 1.24A 4f8yA-5wx3A:
undetectable
4f8yB-5wx3A:
undetectable		 4f8yA-5wx3A:
16.25
4f8yB-5wx3A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		4 / 5 LEU A 313
ASP A 288
TRP A 289
ILE A 286
 None
 1.35A 4mwrA-5wx3A:
undetectable		 4mwrA-5wx3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 ALA A 236
ILE A 121
ILE A 152
GLY A 160
ALA A 161
 None
 1.14A 4nkvA-5wx3A:
undetectable		 4nkvA-5wx3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 ALA A 236
ILE A 121
ILE A 152
GLY A 160
ALA A 161
 None
 1.12A 4nkvC-5wx3A:
undetectable		 4nkvC-5wx3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 ALA A 236
ILE A 121
ILE A 152
GLY A 160
ALA A 161
 None
 1.10A 4nkvD-5wx3A:
undetectable		 4nkvD-5wx3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		4 / 6 GLU A 374
THR A 162
LEU A 166
GLN A 238
 None
 1.37A 4qztA-5wx3A:
undetectable		 4qztA-5wx3A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		4 / 7 ASN A 232
PHE A 231
TRP A 361
PHE A 281
 None
 1.13A 4v32C-5wx3A:
undetectable		 4v32C-5wx3A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		5 / 10 ILE A 182
LEU A 137
VAL A 185
LEU A  98
GLU A 101
 None
 1.40A 5tixB-5wx3A:
undetectable		 5tixB-5wx3A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		4 / 8 ARG A  87
PHE A 192
ASP A 201
LEU A 202
 None
 0.82A 5x5qF-5wx3A:
undetectable		 5x5qF-5wx3A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 PHE A 158
GLY A 368
VAL A 268
ILE A 339
GLY A 160
 None
 1.20A 6c2mB-5wx3A:
undetectable		 6c2mB-5wx3A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		5 / 10 VAL A 183
ALA A 215
LEU A 120
LEU A 117
LEU A 137
 None
 0.83A 6f6nA-5wx3A:
undetectable
6f6nB-5wx3A:
undetectable		 6f6nA-5wx3A:
11.87
6f6nB-5wx3A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5wx3 ALKYLDIKETIDE-COA
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 GLY A 351
GLY A 356
GLY A 358
ALA A 382
PHE A 231
 None
 1.09A 6nj9K-5wx3A:
undetectable		 6nj9K-5wx3A:
20.48