SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wx4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 GLY A 174
LEU A 376
LEU A 390
VAL A 245
ALA A 180
 None
 1.26A 1gseA-5wx4A:
undetectable		 1gseA-5wx4A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 8 VAL A 348
SER A 347
ASN A 342
ASP A 198
 None
 1.22A 1hwiB-5wx4A:
undetectable		 1hwiB-5wx4A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 8 VAL A 348
SER A 347
ASN A 342
ASP A 198
 None
 1.23A 1hwkA-5wx4A:
undetectable		 1hwkA-5wx4A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 8 VAL A 348
SER A 347
ASN A 342
ASP A 198
 None
 1.24A 1hwkC-5wx4A:
undetectable		 1hwkC-5wx4A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 8 VAL A 348
SER A 347
ASN A 342
ASP A 198
 None
 1.24A 1hwkD-5wx4A:
undetectable		 1hwkD-5wx4A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 8 ILE A 228
ALA A 116
LEU A 150
ILE A 130
 None
 0.81A 2w9sE-5wx4A:
undetectable		 2w9sE-5wx4A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 GLY A 169
CYH A 170
ILE A 315
LEU A 273
TYR A 215
 None
 1.09A 3cs8A-5wx4A:
undetectable		 3cs8A-5wx4A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 8 VAL A 348
VAL A 375
PHE A 377
HIS A 309
 None
 1.04A 3fhxB-5wx4A:
undetectable		 3fhxB-5wx4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 4 LEU A 264
MET A 164
ILE A 103
ASP A 222
 None
 1.22A 3hecA-5wx4A:
undetectable		 3hecA-5wx4A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		3 / 3 ASN A 342
ASP A 198
ARG A 178
 None
 0.88A 3k13A-5wx4A:
undetectable		 3k13A-5wx4A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 5 SER A 378
SER A 347
VAL A 348
GLY A 174
 None
 1.03A 3rxhA-5wx4A:
undetectable		 3rxhA-5wx4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 5 ASP A 317
LEU A 316
ILE A 281
PRO A 278
 None
 1.06A 3s3vA-5wx4A:
undetectable		 3s3vA-5wx4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 TYR A 340
GLY A 221
PHE A  37
ASN A  32
GLU A 339
 None
 1.32A 3s8pA-5wx4A:
undetectable		 3s8pA-5wx4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 8 VAL A 195
LEU A 193
ILE A 134
ASP A 147
 None
 0.62A 3wzeA-5wx4A:
undetectable		 3wzeA-5wx4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 LEU A 323
TYR A 306
LYS A 329
SER A 294
SER A 303
 None
 1.29A 4zbrA-5wx4A:
undetectable		 4zbrA-5wx4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_NPSA602_1
(SERUM ALBUMIN)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 LEU A 323
TYR A 306
LYS A 329
SER A 294
SER A 303
 None
 1.29A 5dbyA-5wx4A:
undetectable		 5dbyA-5wx4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 7 HIS A 309
ILE A 351
VAL A 308
ARG A 334
 None
 1.19A 5kkzC-5wx4A:
undetectable
5kkzE-5wx4A:
undetectable		 5kkzC-5wx4A:
19.75
5kkzE-5wx4A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 7 HIS A 309
ILE A 351
VAL A 308
ARG A 334
 None
 1.15A 5kkzK-5wx4A:
undetectable
5kkzQ-5wx4A:
undetectable		 5kkzK-5wx4A:
22.25
5kkzQ-5wx4A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		5 / 12 LEU A 330
PHE A 379
VAL A 246
GLY A 282
LEU A 323
 None
 1.04A 6a7pA-5wx4A:
undetectable		 6a7pA-5wx4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 5wx4 ALKYLQUINOLONE
SYNTHASE
(Tetradium
ruticarpum) 		4 / 5 GLU A  39
VAL A  71
LEU A 337
HIS A 309
 None
 1.37A 6dyoA-5wx4A:
undetectable		 6dyoA-5wx4A:
9.80